公开(公告)号：US20240294900A1

公开(公告)日：2024-09-05

申请号：US18403239

申请日：2024-01-03

申请人： La Jolla Institute for Immunology ,  J. Craig Venter Institute

发明人： Alessandro Sette ,  Alba Grifoni ,  Alison Tarke ,  Yun Zhang ,  Richard Scheuerman

IPC分类号： C12N15/10

CPC分类号： C12N15/1037 ,  C12N15/1055

摘要： The present invention includes compositions and methods for detecting the presence of: a coronavirus or an immune response relevant to a coronavirus infection including T cells responsive to one or more coronavirus peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166), or a subsequence, portion, homologue, variant or derivative thereof; a fusion protein comprising one or more amino acid sequences selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166); a pool of 2 or more peptides selected from the amino acid sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166); or a polynucleotide that encodes one or more peptides or proteins, comprising, consisting of, or consisting essentially of an amino acid sequence selected from those sequences set forth in Tables 1 or 2 (SEQ ID NOS: 1 to 166), or a subsequence, portion, homologue, variant or derivative thereof. The invention further provides vaccines, diagnostics, therapies, and kits, comprising such proteins or peptides.

公开(公告)号：US20240263237A1

公开(公告)日：2024-08-08

申请号：US18564599

申请日：2022-05-27

申请人： La Jolla Institute for Immunology

发明人： Alessandro Sette ,  Cecilia Lindestam Arlehamn

IPC分类号： C12Q1/6883

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： This disclosure provides methods for determining whether a subject is suffering from a neurodegenerative disease, and/or methods of treating a neurodegenerative disease. The disclosed methods comprise detecting differential expression one or more genes or gene products from a sample obtained from the subject.

公开(公告)号：US20230293630A1

公开(公告)日：2023-09-21

申请号：US17760402

申请日：2021-02-11

申请人： La Jolla Institute for Immunology

发明人： Alessandro Sette ,  Shane Crotty ,  Alba Grifoni ,  Daniela Weiskopf ,  Bjoern Peters ,  John Sidney

IPC分类号： A61K38/16 ,  C07K14/005 ,  A61K38/20 ,  A61K38/18 ,  A61K38/21 ,  G01N33/50 ,  G01N33/569 ,  C12N15/63 ,  A61P31/14

CPC分类号： A61K38/162 ,  A61K38/1841 ,  A61K38/204 ,  A61K38/2066 ,  A61K38/217 ,  A61P31/14 ,  C07K14/005 ,  C12N15/63 ,  G01N33/505 ,  G01N33/56983 ,  G01N2333/165

摘要： The present invention includes compositions and methods for detecting the presence of: a coronavirus or an immune response to a coronavirus infection including T cells responsive to one or more coronavirus peptides or proteins comprising, consisting of, or consisting essentially of: one or more amino acid sequences selected from SEQ ID NO: 1 to 1126, subsequences, portions, homologues, variants or derivatives; a fusion protein comprising one or more amino acid sequences selected from SEQ ID NO: 1 to 1126; a pool of peptides or proteins selected from the amino acid sequences set forth in SEQ ID NO: 1 to 1126; or a polynucleotide that encodes one or more peptides or proteins, comprising, consisting of, or consisting essentially of an amino acid sequence selected from SEQ ID NO: 1 to 1126, subsequences, portions, homologues, variants or derivatives. The invention further provides vaccines, diagnostics, therapies, and kits, comprising such proteins or peptides.