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公开(公告)号：US20150307624A1
公开(公告)日：2015-10-29
申请号：US14702143
申请日：2015-05-01
发明人： Dominique Bourel , Sylvie Jorieux , Christophe de Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
摘要翻译： 本发明涉及在所选细胞系中产生的人或人源化嵌合单克隆抗体的用途，所述抗体导致高ADCC活性以及细胞因子和白细胞介素的高分泌，用于治疗所谓的弱反应患者的人群 显示CD16 FCGR3A-158F纯合子或FCGR3A-158V / F杂合子多态性。
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公开(公告)号：US20140017243A1
公开(公告)日：2014-01-16
申请号：US13930070
申请日：2013-06-28
发明人： Dominique Bourel , Sylvie Jorieux , Christophe de Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： C07K16/18
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
摘要翻译： 本发明涉及在所选细胞系中产生的人或人源化嵌合单克隆抗体的用途，所述抗体导致高ADCC活性以及细胞因子和白细胞介素的高分泌，用于治疗所谓的弱反应患者的人群 显示CD16 FCGR3A-158F纯合子或FCGR3A-158V / F杂合子多态性。
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公开(公告)号：US10081683B2
公开(公告)日：2018-09-25
申请号：US15616596
申请日：2017-06-07
发明人： Roland Beliard , Dominique Bourel , Arnaud Glacet , Christophe de Romeuf , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： C07K16/00 , A61K39/395 , C07K16/34 , A61K39/00
摘要： The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for hemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP).
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公开(公告)号：US09718890B2
公开(公告)日：2017-08-01
申请号：US14676508
申请日：2015-04-01
发明人： Roland Beliard , Dominique Bourel , Arnaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
CPC分类号： C07K16/34 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/732
摘要： The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADCC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for hemolytic disease in a new-born baby or for uses such as idiopathic thrombocytopenic purpura (ITP).
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公开(公告)号：US09708409B2
公开(公告)日：2017-07-18
申请号：US14157061
申请日：2014-01-16
发明人： Roland Beliard , Dominique Bourel , Arnaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： C07K16/00 , A61K39/395 , C12N5/00 , C07K16/34 , A61K39/00
CPC分类号： C07K16/34 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/732
摘要： The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP).
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公开(公告)号：US09109020B2
公开(公告)日：2015-08-18
申请号：US13930070
申请日：2013-06-28
发明人： Dominique Bourel , Sylvie Jorieux , Christophe De Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , C07K16/34 , A61K39/00
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
摘要翻译： 本发明涉及在所选细胞系中产生的人或人源化嵌合单克隆抗体的用途，所述抗体导致高ADCC活性以及细胞因子和白细胞介素的高分泌，用于治疗所谓的弱反应患者的人群 显示CD16 FCGR3A-158F纯合子或FCGR3A-158V / F杂合子多态性。
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公开(公告)号：US09879089B2
公开(公告)日：2018-01-30
申请号：US14702143
申请日：2015-05-01
发明人： Dominique Bourel , Sylvie Jorieux , Christophe de Romeuf , Philippe Klein , Christine Gaucher , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , C07K16/34 , A61K39/00
CPC分类号： C07K16/34 , A61K2039/505 , C07K16/18 , C07K16/2833 , C07K2317/14 , C07K2317/41 , C07K2317/732 , Y02A50/412
摘要： The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said antibodies bringing about a high ADCC activity as well as a high secretion of cytokines and interleukins, for treating underpopulations of so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote or FCGR3A-158V/F heterozygote polymorphism.
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公开(公告)号：US09718889B2
公开(公告)日：2017-08-01
申请号：US14617836
申请日：2015-02-09
发明人： Roland Beliard , Dominique Bourel , Amaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
CPC分类号： C07K16/34 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/732
摘要： The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADCC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby or for uses such as idiopathic thrombocytopenic purpura (ITP).
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公开(公告)号：US20150266972A1
公开(公告)日：2015-09-24
申请号：US14676508
申请日：2015-04-01
发明人： Roland BELIARD , Dominique Bourel , Arnaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： C07K16/34
CPC分类号： C07K16/34 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/732
摘要： The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP)
摘要翻译： 本发明涉及通过ADDC型测试获得和选择单克隆抗体的方法，所述抗体能够激活III型Fcy受体并具有特定的聚糖结构。 本发明的抗-D抗体可用于预防Rh阴性人中的恒河猴同种免疫，特别是用于新生婴儿如特发性血小板减少性小蛹9ITP的溶血性疾病）
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公开(公告)号：US20150152189A1
公开(公告)日：2015-06-04
申请号：US14617836
申请日：2015-02-09
发明人： Roland Beliard , Dominique Bourel , Amaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
IPC分类号： C07K16/34
CPC分类号： C07K16/34 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/732
摘要： The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic pupura 9ITP)
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