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    Nanoscale object detection using a whispering gallery mode resonator
    3.
    发明授权
    Nanoscale object detection using a whispering gallery mode resonator 有权
    使用耳语画廊模式谐振器进行纳米物体检测

    公开(公告)号：US08704155B2

    公开(公告)日：2014-04-22

    申请号：US12966785

    申请日：2010-12-13

    申请人： Lina He ,  Jiangang Zhu ,  Sahin Kaya Ozdemir ,  Lan Yang ,  Da-Ren Chen

    发明人： Lina He ,  Jiangang Zhu ,  Sahin Kaya Ozdemir ,  Lan Yang ,  Da-Ren Chen

    IPC分类号： G01J9/00

    CPC分类号： G01N21/7746

    摘要： Detection of individual objects using a light source and a whispering gallery mode (WGM) resonator. Light from the whispering gallery mode (WGM) resonator is analyzed. The presence of an object is determined based on mode splitting associated with the light received by the photodetector. For example, the presence of the object may be determined based on the distance between two whispering gallery modes and/or the linewidths of the two modes in a transmission spectrum. Alternatively, the presence of the object may be determined based on a beat frequency that is determined based on a heterodyne beat signal produced by combining split laser modes in the received light from a WGM microcavity laser.

    摘要翻译： 使用光源和耳语画廊模式（WGM）谐振器检测各个物体。 分析了来自耳语堂模式（WGM）谐振器的光。 基于与由光电检测器接收的光相关联的模式分割来确定对象的存在。 例如，可以基于两个耳语画廊模式之间的距离和/或发送频谱中的两种模式的线宽来确定对象的存在。 或者，可以基于基于通过在来自WGM微腔激光器的接收光中组合分割激光模式而产生的外差拍频确定的拍频来确定对象的存在。

    HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF
    7.
    发明申请
    HUMAN ANTIBODIES THAT BIND MESOTHELIN, AND USES THEREOF 有权
    MESOTHELIN的人体抗体及其用途

    公开(公告)号：US20110262448A1

    公开(公告)日：2011-10-27

    申请号：US12681215

    申请日：2008-09-29

    申请人： Jonathan A. TERRETT ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

    发明人： Jonathan A. TERRETT ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K39/44 ,  C07K16/18

    CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92 ,  A61K2300/00

    摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

    摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。

    Fully integrated parity-time symmetric electronics
    8.
    发明授权
    Fully integrated parity-time symmetric electronics 有权

    公开(公告)号：US11637355B1

    公开(公告)日：2023-04-25

    申请号：US17446000

    申请日：2021-08-26

    申请人： Xuan Zhang ,  Lan Yang ,  Weidong Cao ,  Weijian Chen

    发明人： Xuan Zhang ,  Lan Yang ,  Weidong Cao ,  Weijian Chen

    IPC分类号： H01P1/32 ,  H01P1/38 ,  H01P1/36

    摘要： An integrated circuit is disclosed. The integrated circuit includes a first resonator, a second resonator, and a coupling element. The first resonator has a first terminal and a second terminal, where the first resonator comprises a gain resistor, a gain capacitor, and a gain inductor in parallel and electrically coupling the first terminal with the second terminal. The second resonator has a third terminal and a fourth terminal, where the second resonator includes a loss resistor, a loss capacitor, and a loss inductor in parallel and electrically coupling the third terminal with the fourth terminal. The coupling element selectively couples the first terminal of the first resonator with the third terminal of the second resonator.

    Human antibodies that bind mesothelin, and uses thereof
    10.
    发明授权
    Human antibodies that bind mesothelin, and uses thereof 有权
    结合间皮素的人抗体及其用途

    公开(公告)号：US08399623B2

    公开(公告)日：2013-03-19

    申请号：US13587500

    申请日：2012-08-16

    申请人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

    发明人： Jonathan A. Terrett ,  Sarah L. Pogue ,  Kristopher Toy ,  Lan Yang ,  Chetana Rao-Naik ,  Bingliang Chen

    IPC分类号： C07K16/00 ,  C12P21/08

    CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K47/6869 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/80 ,  C07K2317/92 ,  A61K2300/00

    摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to mesothelin with high affinity, particularly human monoclonal antibodies. Preferably, the antibodies bind human mesothelin. In certain embodiments, the antibodies are capable of internalizing into mesothelin-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity. The invention further provides anti-mesothelin antibodies that can inhibit the binding of mesothelin to the ovarian cancer antigen CA125. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting mesothelin, as well as methods for treating cancers, such as mesotheliomas, pancreatic cancers and ovarian cancers, using an anti-mesothelin antibody of this disclosure.

    摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合间皮素的分离的单克隆抗体。 优选地，所述抗体结合人间皮素。 在某些实施方案中，抗体能够内化成表达间皮素的细胞或能够介导抗原依赖性细胞毒性。 本发明还提供可以抑制间皮素与卵巢癌抗原CA125的结合的抗间皮素抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了使用本公开的抗间皮素抗体检测间皮素的方法以及用于治疗癌症的方法，诸如间皮瘤，胰腺癌和卵巢癌。