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公开(公告)号：US09028824B2
公开(公告)日：2015-05-12
申请号：US13474466
申请日：2012-05-17
申请人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
发明人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US20120202285A1
公开(公告)日：2012-08-09
申请号：US13454296
申请日：2012-04-24
申请人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
发明人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
摘要翻译： 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。
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公开(公告)号：US08236930B2
公开(公告)日：2012-08-07
申请号：US13099196
申请日：2011-05-02
申请人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
发明人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
IPC分类号： C07K16/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US20120009622A1
公开(公告)日：2012-01-12
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US20110206681A1
公开(公告)日：2011-08-25
申请号：US13099196
申请日：2011-05-02
申请人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
发明人： Jing Min , Yanli Wu , Rory F. Finn , Barrett R. Thiele , Wei Liao , Ronald P. Gladue , Arvind Rajpal , Timothy J. Paradis , Peter Brams , Brigitte Devaux , Yi Wu , Kristopher Toy , Heidi N. LeBlanc , Haichun Huang
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
摘要翻译： 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。
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公开(公告)号：US20110166330A1
公开(公告)日：2011-07-07
申请号：US12931528
申请日：2011-02-02
申请人： Brian Kobilka , Daniel Rohrer , Peter Brams , Asna Masood
发明人： Brian Kobilka , Daniel Rohrer , Peter Brams , Asna Masood
IPC分类号： C07K16/00
CPC分类号： C07K16/2869 , C07K14/723 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.
摘要翻译： 提供了特异性结合GPCR的IC3环上的三维表位的抗体。 抗体可以用于包括：使GPCR与单价形式的抗体结合条件接触以形成复合物; 并使该络合物结晶。
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7.发明授权Method for obtaining G protein-coupled receptor (GPCR) diffraction-quality crystals employing a monoclonal antibody that binds to the third intracellular loop (IL3) 失效使用结合第三细胞内环（IL3）的单克隆抗体获得G蛋白偶联受体（GPCR）衍射质量晶体的方法公开(公告)号：US07947807B2
公开(公告)日：2011-05-24
申请号：US12284245
申请日：2008-09-19
申请人： Brian Kobilka , Dan Rohrer , Peter Brams , Asna Masood
发明人： Brian Kobilka , Dan Rohrer , Peter Brams , Asna Masood
CPC分类号： C07K16/2869 , C07K14/723 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： An antibody that specifically binds a three dimensional epitope on the IC3 loop of a GPCR is provided. The antibody may be employed in a method that comprises: contacting a GPCR with a monovalent version of the antibody binding conditions to form a complex; and crystallizing the complex.
摘要翻译： 提供了特异性结合GPCR的IC3环上的三维表位的抗体。 抗体可以用于包括：使GPCR与单价形式的抗体结合条件接触以形成复合物; 并使该络合物结晶。
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公开(公告)号：US07851181B2
公开(公告)日：2010-12-14
申请号：US11835791
申请日：2007-08-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： C12P21/02
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US20100104508A1
公开(公告)日：2010-04-29
申请号：US12444130
申请日：2007-10-01
IPC分类号： A61K51/00 , C07K16/28 , A61K39/395 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , C12N5/02
CPC分类号： C07K16/2866 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76
摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.
摘要翻译： 本公开提供以高亲和力特别是人单克隆抗体特异性结合CXCR4的分离的单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CXCR4的方法，以及使用本公开的抗CXCR4抗体治疗各种癌症，炎性疾病和HIV感染的方法。
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公开(公告)号：US20090317402A1
公开(公告)日：2009-12-24
申请号：US12480991
申请日：2009-06-09
申请人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
发明人： Arvind Rajpal , Madhav Devalaraja , Kristopher Toy , Lan Yang , Haichun Huang , Jun Zhang , Peter Brams , Brigitte Devaux , David B. Passmore
IPC分类号： A61K39/395 , C07K16/24 , C12N1/21 , C12N15/00 , C12N15/11
CPC分类号： C07K16/248 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.
摘要翻译： 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。
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