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公开(公告)号：US20090069238A1
公开(公告)日：2009-03-12
申请号：US12192900
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US08071110B2
公开(公告)日：2011-12-06
申请号：US12192546
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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公开(公告)号：US07897157B2
公开(公告)日：2011-03-01
申请号：US11845252
申请日：2007-08-27
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US08273358B2
公开(公告)日：2012-09-25
申请号：US12192900
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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公开(公告)号：US07740868B2
公开(公告)日：2010-06-22
申请号：US11832173
申请日：2007-08-01
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Sanjiv Ghanshani , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K1/22 , C07K14/33 , C07K14/68 , C07K14/695 , C12N9/52
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US20090005313A1
公开(公告)日：2009-01-01
申请号：US12192419
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US20080161226A1
公开(公告)日：2008-07-03
申请号：US11845167
申请日：2007-08-27
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
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公开(公告)号：US20090018081A1
公开(公告)日：2009-01-15
申请号：US12192854
申请日：2008-08-15
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
IPC分类号： A61K38/16 , C07K14/00 , C07K14/655 , C07K16/00 , A61P37/02 , C12N15/64 , C07H21/00 , C12P21/00
CPC分类号： C12N9/52 , C07K14/33 , C07K14/575 , C07K14/57509 , C07K14/635 , C07K14/655 , C07K2319/035 , C07K2319/50 , C07K2319/55
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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公开(公告)号：US07749514B2
公开(公告)日：2010-07-06
申请号：US11845167
申请日：2007-08-27
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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公开(公告)号：US20080221012A1
公开(公告)日：2008-09-11
申请号：US11845252
申请日：2007-08-27
申请人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
发明人： Lance E. Steward , Joseph Francis , Ester Fernandez-Salas , Marcella A. Gilmore , Shengwen Li , J. Oliver Dolly , Kei Roger Aoki
CPC分类号： C07K14/33 , A61K38/00 , C12N9/52 , Y02A50/469
摘要： Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.
摘要翻译： 包含可活化的重组神经毒素和由其衍生的多肽的组合物。 本发明还包括编码这种多肽的核酸，以及制备这种多肽和核酸的方法。
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