公开(公告)号：US11174223B2

公开(公告)日：2021-11-16

申请号：US15593540

申请日：2017-05-12

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Heike S. Radeke ,  Joel Lazewatsky ,  L. Veronica Lee

IPC: A61K51/00 ,  A61M36/14 ,  C07C303/30 ,  A61K51/04 ,  C07B59/00 ,  C07C53/06 ,  C07C217/58 ,  C07C255/54 ,  C07C279/10 ,  C07C279/24 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C277/08 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C277/00

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

公开(公告)号：US20160362362A1

公开(公告)日：2016-12-15

申请号：US15170848

申请日：2016-06-01

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Edward H. Cheesman ,  Richard R. Cesati ,  Richard J. Looby ,  Heike S. Radeke

IPC: C07C303/30 ,  C07B59/00 ,  C07C277/08

CPC classification number: C07C303/30 ,  A61K51/00 ,  A61K51/04 ,  A61K51/0406 ,  C07B59/001 ,  C07B2200/05 ,  C07C53/06 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C217/58 ,  C07C255/54 ,  C07C277/00 ,  C07C277/08 ,  C07C279/10 ,  C07C279/24 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C279/08

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

公开(公告)号：US20220017459A1

公开(公告)日：2022-01-20

申请号：US17387478

申请日：2021-07-28

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Heike S. Radeke ,  Joel Lazewatsky ,  L. Veronica Lee

IPC: C07C303/30 ,  A61K51/04 ,  C07B59/00 ,  C07C53/06 ,  C07C217/58 ,  C07C255/54 ,  C07C279/10 ,  C07C279/24 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C277/08 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

公开(公告)号：US20170355669A1

公开(公告)日：2017-12-14

申请号：US15593540

申请日：2017-05-12

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Heike S. Radeke ,  Joel Lazewatsky ,  L. Veronica Lee

IPC: C07C303/30 ,  A61K51/04 ,  C07C53/10 ,  C07C53/06 ,  C07C309/66 ,  C07C303/28 ,  C07C213/02 ,  C07C309/73 ,  C07B59/00 ,  C07C279/10 ,  C07C277/08 ,  C07C279/24 ,  C07C255/54 ,  C07C309/04 ,  C07C217/58 ,  C07C309/30 ,  C07C309/65 ,  C07C63/08 ,  C07C53/18 ,  C07C277/00 ,  A61K51/00

CPC classification number: C07C303/30 ,  A61K51/00 ,  A61K51/04 ,  A61K51/0406 ,  C07B59/001 ,  C07B2200/05 ,  C07C53/06 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C217/58 ,  C07C255/54 ,  C07C277/00 ,  C07C277/08 ,  C07C279/10 ,  C07C279/24 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C279/08

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

公开(公告)号：US09682927B2

公开(公告)日：2017-06-20

申请号：US15170848

申请日：2016-06-01

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Edward H. Cheesman ,  Richard R. Cesati ,  Richard J. Looby ,  Heike S. Radeke

IPC: A61K51/00 ,  A61M36/14 ,  C07C303/30 ,  A61K51/04 ,  C07B59/00 ,  C07C53/06 ,  C07C217/58 ,  C07C255/54 ,  C07C277/08 ,  C07C279/10 ,  C07C279/24 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C277/00

CPC classification number: C07C303/30 ,  A61K51/00 ,  A61K51/04 ,  A61K51/0406 ,  C07B59/001 ,  C07B2200/05 ,  C07C53/06 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C217/58 ,  C07C255/54 ,  C07C277/00 ,  C07C277/08 ,  C07C279/10 ,  C07C279/24 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C279/08

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.