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公开(公告)号:US20140113901A1
公开(公告)日:2014-04-24
申请号:US14007427
申请日:2011-04-07
申请人: Lars Bärfacker , William Sott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
发明人: Lars Bärfacker , William Sott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号: C07D487/04 , A61K45/06 , A61K31/5025
CPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
摘要: Imidazopyridazines of formula (I) a process for their production and the use thereof.
摘要翻译: 式(I)的咪唑并哒嗪其制备方法及其用途。
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公开(公告)号:US09206185B2
公开(公告)日:2015-12-08
申请号:US14007427
申请日:2012-04-05
申请人: Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
发明人: Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
摘要: The application relates to imidazopyridazines of formula (I) which are useful as Akt inhibitors suitable for the treatment of cancer, and processes for their production and the use thereof.
摘要翻译: 本申请涉及可用作适于治疗癌症的Akt抑制剂及其制备方法及其用途的式(I)咪唑并哒嗪。
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公开(公告)号:US20130184273A1
公开(公告)日:2013-07-18
申请号:US13808461
申请日:2011-07-11
申请人: Stuart Ince , Hartmut Rehwinkel , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer
发明人: Stuart Ince , Hartmut Rehwinkel , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号: A61K31/5377 , A61K31/519 , A61K45/06 , C07D487/04
CPC分类号: A61K31/5377 , A61K31/519 , A61K45/06 , C07D487/04
摘要: Compounds of formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物处理其生产和用作药物。
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公开(公告)号:US20130210825A1
公开(公告)日:2013-08-15
申请号:US13812555
申请日:2011-07-27
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacuture and their use for the treatment of benign and malignant neoplasia.
摘要翻译: 本发明涉及通式(I)的咪唑并[1,2-b]哒嗪其制备方法及其用于治疗良性和恶性肿瘤的方法。
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公开(公告)号:US08987273B2
公开(公告)日:2015-03-24
申请号:US13812555
申请日:2011-07-27
IPC分类号: A61K31/501 , C07D237/26 , C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacture and their use for the treatment of benign and malignant neoplasia.
摘要翻译: 本发明涉及通式(I)的咪唑并[1,2-b]哒嗪,其制备及其用于治疗良性和恶性肿瘤的方法。
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6.SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY 有权
标题翻译: 取代的PYRIMIDO [1,2-B]吲哚并作为PI3K / AKT途径的调节剂使用公开(公告)号:US20130310405A1
公开(公告)日:2013-11-21
申请号:US13994517
申请日:2011-12-13
IPC分类号: C07D487/04 , A61K45/06 , A61K31/519
CPC分类号: C07D487/04 , A61K31/519 , A61K45/06
摘要: Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物可用于生产和用作药物。 式(I)的化合物a:可用于治疗癌症。
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公开(公告)号:US08975265B2
公开(公告)日:2015-03-10
申请号:US13808430
申请日:2011-07-07
申请人: Stuart Ince , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer , William Scott
发明人: Stuart Ince , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer , William Scott
IPC分类号: A01N43/90 , A61K31/519 , A61K31/437 , C07D471/04 , C07D487/04 , A61K45/06 , C07F5/04
CPC分类号: A61K31/437 , A61K31/519 , A61K45/06 , C07D471/04 , C07D487/04 , C07F5/04
摘要: Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物,其制备方法及其作为药物的用途。
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公开(公告)号:US20130190332A1
公开(公告)日:2013-07-25
申请号:US13808430
申请日:2011-07-07
申请人: Stuart Ince , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer , William Scott
发明人: Stuart Ince , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer , William Scott
IPC分类号: A61K31/437 , A61K45/06 , C07D471/04 , C07F5/04 , C07D487/04 , A61K31/519
CPC分类号: A61K31/437 , A61K31/519 , A61K45/06 , C07D471/04 , C07D487/04 , C07F5/04
摘要: Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物,其制备方法及其作为药物的用途。
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9.Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway 有权
标题翻译: 取代的嘧啶并[1,2-b]吲唑及其作为Pi3K / Akt途径的调节剂的用途公开(公告)号:US08987286B2
公开(公告)日:2015-03-24
申请号:US13994517
申请日:2011-12-13
IPC分类号: C07D487/04 , A61K31/519 , A61K45/06
CPC分类号: C07D487/04 , A61K31/519 , A61K45/06
摘要: Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物可用于生产和用作药物。 式(I)的化合物a:可用于治疗癌症。
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公开(公告)号:US08957064B2
公开(公告)日:2015-02-17
申请号:US13201277
申请日:2010-02-02
申请人: Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer , Barbara Beckers
发明人: Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Thomas Beckers , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer
IPC分类号: A61K31/495 , A61K31/519 , A61K31/505 , C07D401/12 , C07D487/04 , A61K45/06 , C07D471/04
CPC分类号: A61K31/519 , A61K31/495 , A61K31/505 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04
摘要: Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 式(I)化合物或所述化合物的N-氧化物,盐,互变异构体或立体异构体,或所述N-氧化物,互变异构体或立体异构体的盐,其中环B和与其稠合的嘧啶,R4 R5,R6,R7,m和n具有在描述和权利要求中给出的含义,它们是Pi3K / Akt途径的有效抑制剂,其生产方法及其作为药物的用途。
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