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    Neuroprotective agents
    1.
    发明授权
    Neuroprotective agents 失效
    神经保护剂

    公开(公告)号：US07026297B2

    公开(公告)日：2006-04-11

    申请号：US10719599

    申请日：2003-11-20

    申请人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    发明人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    IPC分类号： C07K5/06

    CPC分类号： C07C279/14 ,  C07C237/10 ,  C07D209/20

    摘要： Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of carbon atoms in said straight chains of Rb and Rc being 7); R2 and R3 each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1 represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.

    摘要翻译： 式（I）化合物其中：Q表示脒基，氰基或式XYN-基团（其中X和Y为氢或各种基团）; R a表示亚烷基; R b和R c各自表示亚烷基，R b和R c中的所述直链中的碳原子总数， / SUP>为7）; R 2和R 3各自表示氢或式R，RCO-，ROCO-或RNHCO-的基团，其中R表示烷基或芳基; 由星号表示的手性碳原子为L构型; Z是芳香族氨基酸残基; n为0或1; R 1表示氢，烷基或芳基; W表示氢，烷基或芳基; 及其药学上可接受的盐具有保护免受由缺血事件引起的神经元损伤的能力。

    Neuroprotective agents
    2.
    发明授权
    Neuroprotective agents 失效
    神经保护剂

    公开(公告)号：US06797699B1

    公开(公告)日：2004-09-28

    申请号：US09581397

    申请日：2000-10-02

    申请人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    发明人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    IPC分类号： C07K506

    CPC分类号： C07C279/14 ,  C07C237/10 ,  C07D209/20

    摘要： Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of carbon atoms in said straight chains of Rb and Rc being 7); R2 and R3 each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1 represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.

    摘要翻译： 式（I）化合物其中：Q表示脒基，氰基或式XYN-基团（其中X和Y为氢或各种基团）; R“>代表亚烷基; R b和R c各自表示亚烷基，R 3和R c的所述直链中的总碳原子数为7）; R 2和R 3各自表示氢或式R，RCO-，ROCO-或RNHCO-的基团，其中R表示烷基或芳基; 由星号表示的手性碳原子为L构型; Z是芳香族氨基酸残基; n为0或1; R 1表示氢，烷基或芳基; W表示氢，烷基或芳基; 及其药学上可接受的盐具有保护免受由缺血事件引起的神经元损伤的能力。