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    Neuroprotective agents
    1.
    发明授权
    Neuroprotective agents 失效
    神经保护剂

    公开(公告)号：US06797699B1

    公开(公告)日：2004-09-28

    申请号：US09581397

    申请日：2000-10-02

    申请人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    发明人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    IPC分类号： C07K506

    CPC分类号： C07C279/14 ,  C07C237/10 ,  C07D209/20

    摘要： Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of carbon atoms in said straight chains of Rb and Rc being 7); R2 and R3 each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1 represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.

    摘要翻译： 式（I）化合物其中：Q表示脒基，氰基或式XYN-基团（其中X和Y为氢或各种基团）; R“>代表亚烷基; R b和R c各自表示亚烷基，R 3和R c的所述直链中的总碳原子数为7）; R 2和R 3各自表示氢或式R，RCO-，ROCO-或RNHCO-的基团，其中R表示烷基或芳基; 由星号表示的手性碳原子为L构型; Z是芳香族氨基酸残基; n为0或1; R 1表示氢，烷基或芳基; W表示氢，烷基或芳基; 及其药学上可接受的盐具有保护免受由缺血事件引起的神经元损伤的能力。

    Neuroprotective agents
    2.
    发明授权
    Neuroprotective agents 失效
    神经保护剂

    公开(公告)号：US07026297B2

    公开(公告)日：2006-04-11

    申请号：US10719599

    申请日：2003-11-20

    申请人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    发明人： Lars Eric Sundstrom ,  Fausto Iannotti ,  Mark Bradley ,  Ashley Ker Pringle

    IPC分类号： C07K5/06

    CPC分类号： C07C279/14 ,  C07C237/10 ,  C07D209/20

    摘要： Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of carbon atoms in said straight chains of Rb and Rc being 7); R2 and R3 each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1 represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.

    摘要翻译： 式（I）化合物其中：Q表示脒基，氰基或式XYN-基团（其中X和Y为氢或各种基团）; R a表示亚烷基; R b和R c各自表示亚烷基，R b和R c中的所述直链中的碳原子总数， / SUP>为7）; R 2和R 3各自表示氢或式R，RCO-，ROCO-或RNHCO-的基团，其中R表示烷基或芳基; 由星号表示的手性碳原子为L构型; Z是芳香族氨基酸残基; n为0或1; R 1表示氢，烷基或芳基; W表示氢，烷基或芳基; 及其药学上可接受的盐具有保护免受由缺血事件引起的神经元损伤的能力。

    COPOLYMERS SUITABLE FOR USE IN CORNEAL BANDAGES
    7.
    发明申请
    COPOLYMERS SUITABLE FOR USE IN CORNEAL BANDAGES 审中-公开
    适用于角钢带的共聚物

    公开(公告)号：US20100303890A1

    公开(公告)日：2010-12-02

    申请号：US12444993

    申请日：2007-10-12

    申请人： Guilhem Tourniaire ,  Mark Bradley ,  Albert Liberski

    发明人： Guilhem Tourniaire ,  Mark Bradley ,  Albert Liberski

    IPC分类号： A61F2/14 ,  A61K35/44 ,  A61P27/02 ,  C08F226/00 ,  C08L33/08 ,  A61F13/00

    CPC分类号： C08F220/34 ,  A61F15/00 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3839 ,  A61L2430/16 ,  C08F220/06 ,  C08F220/28 ,  C08L33/04

    摘要： Disclosed is a polymer having an affinity for corneal cells such that it can be used as a substrate for the growth of corneal cells, and so is suitable for use in a corneal bandage, especially in the form of a contact lens in which at least the cornea contacting surface is composed of the polymer. The substrate with an affinity for corneal cells is a copolymer comprising units -(A)- and -(B)- in which the units A are derived from aminoalkyl (alkyl)acrylates and the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, and (alkyl)acrylic acids.

    摘要翻译： 公开了对角膜细胞具有亲和力的聚合物，使得其可以用作角膜细胞生长的底物，因此适用于角膜绷带，特别是以隐形眼镜的形式，其中至少 角膜接触表面由聚合物组成。 具有对角膜细胞亲和力的底物是包含单元 - （A） - 和 - （B））的共聚物，其中单元A衍生自氨基烷基（烷基）丙烯酸酯，并且单元B衍生自芳氧基，烷氧基或羟基烷基（ 烷基）丙烯酸酯和（烷基）丙烯酸。

    Measurement of melting points of multiple samples
    8.
    发明申请
    Measurement of melting points of multiple samples 失效
    测量多个样品的熔点

    公开(公告)号：US20090190626A1

    公开(公告)日：2009-07-30

    申请号：US10575061

    申请日：2004-10-01

    申请人： Mark Bradley ,  Jean-Francois Thaburet

    发明人： Mark Bradley ,  Jean-Francois Thaburet

    IPC分类号： G01N25/04 ,  G01K11/06

    CPC分类号： G01N25/04

    摘要： In a method of measuring a temperature value associated with melting, softening or decomposition of sample substances, an array of samples is deposited onto a support tray. The support tray is placed onto a heating device provided with temperature sensing means, the support tray is illuminated, and the array of samples is observed by a imaging device. WNle varying the temperature of the heating device, the image data from the imaging device is fed to an image recording device and temperature values associated with each feed of image data are also recorded. The image data is reviewed to detect changes in the image, such as image intensity, at each or selected sample locations, and the temperature of the heating device at an image change associated with a change in state of a sample is logged. Image processing software may be used to detect changes in the image, for example in the intensity of the image, at each sample location. The method may be used as a means for rapidly obtaining a melting point value for comparison of the physical characteristics of the members of a library of samples, especially polymer samples.

    摘要翻译： 在测量与样品物质的熔化，软化或分解相关的温度值的方法中，将样品阵列沉积在支撑盘上。 支撑托盘被放置在具有温度检测装置的加热装置上，支撑托盘被照亮，并且通过成像装置观察样品阵列。 通过改变加热装置的温度，将来自成像装置的图像数据馈送到图像记录装置，并且还记录与图像数据的每个进给相关联的温度值。 检查图像数据以检测图像中的变化，例如在每个或所选样品位置处的图像强度，并记录与样品状态变化相关联的图像变化时加热装置的温度。 图像处理软件可用于检测图像的变化，例如在每个采样位置处的图像强度。 该方法可以用作快速获得熔点值的手段，用于比较样品库，特别是聚合物样品的成员的物理特性。

    METHOD AND DEVICE FOR THE PROTECTION OF A PIPE PORTION
    9.
    发明申请
    METHOD AND DEVICE FOR THE PROTECTION OF A PIPE PORTION 审中-公开
    用于保护管道部分的方法和装置

    公开(公告)号：US20080017264A1

    公开(公告)日：2008-01-24

    申请号：US11832961

    申请日：2007-08-02

    申请人： Kevin Douglas ,  Mark Bradley ,  Charles Kennedy ,  Frank Rampton

    发明人： Kevin Douglas ,  Mark Bradley ,  Charles Kennedy ,  Frank Rampton

    IPC分类号： F16L55/16

    CPC分类号： F16L55/1683 ,  F16L55/18 ,  F16L58/1054

    摘要： The present invention provides a method, device and tools for the protection of cadmium welds, holidays or the like on underground pipe portions, wherein the device includes a patch having a fibrous material and a hydrophobic agent that is adapted to form a substantial seal about the pipe portion or otherwise coat the pipe portion with an anti-corrosion agent upon application.

    摘要翻译： 本发明提供了一种用于保护地下管道部分上的镉焊缝，假日等的方法，装置和工具，其中该装置包括具有纤维材料和疏水剂的贴片，该贴剂适于围绕 管道部分或以其他方式在施加时用防腐剂涂覆管部分。

    Method and device for the protection of a pipe portion
    10.
    发明授权
    Method and device for the protection of a pipe portion 有权
    用于保护管道部分的方法和装置

    公开(公告)号：US07273073B2

    公开(公告)日：2007-09-25

    申请号：US10925026

    申请日：2004-08-24

    申请人： Kevin Douglas ,  Mark Bradley ,  Charles W. Kennedy ,  Frank Rampton

    发明人： Kevin Douglas ,  Mark Bradley ,  Charles W. Kennedy ,  Frank Rampton

    IPC分类号： F16L55/16

    CPC分类号： F16L55/1683 ,  F16L55/18 ,  F16L58/1054

    摘要： The present invention provides a method, device and tools for the protection of cadmium welds, holidays or the like on underground pipe portions, wherein the device includes a patch having a fibrous material and a hydrophobic agent that is adapted to form a substantial seal about the pipe portion or otherwise coat the pipe portion with an anti-corrosion agent upon application.

    摘要翻译： 本发明提供了用于保护地下管道部分上的镉焊缝，假日等的方法，装置和工具，其中该装置包括具有纤维材料和疏水剂的贴片，该贴剂适于围绕 管道部分或以其他方式在施加时用防腐剂涂覆管部分。