公开(公告)号：US20060204581A1

公开(公告)日：2006-09-14

申请号：US11433725

申请日：2006-05-12

申请人： Laurie Gower ,  Matthew Olszta ,  Elliot Douglas ,  Sivakumar Munisamy ,  Donna Wheeler

发明人： Laurie Gower ,  Matthew Olszta ,  Elliot Douglas ,  Sivakumar Munisamy ,  Donna Wheeler

IPC分类号： A61K9/14

CPC分类号： A61L27/24 ,  A61L27/446 ,  A61L27/46 ,  A61L31/127 ,  A61L31/128 ,  A61L31/146 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/814 ,  Y10S530/815 ,  Y10S530/817

摘要： The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

公开(公告)号：US20060204580A1

公开(公告)日：2006-09-14

申请号：US11432941

申请日：2006-05-12

申请人： Laurie Gower ,  Matthew Olszta ,  Elliot Douglas ,  Sivakumar Munisamy ,  Donna Wheeler

发明人： Laurie Gower ,  Matthew Olszta ,  Elliot Douglas ,  Sivakumar Munisamy ,  Donna Wheeler

IPC分类号： A61K9/14

CPC分类号： A61L27/24 ,  A61L27/446 ,  A61L27/46 ,  A61L31/127 ,  A61L31/128 ,  A61L31/146 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/814 ,  Y10S530/815 ,  Y10S530/817

摘要： The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a biomimetic of bone. In another aspect, the subject invention concerns a process for making a composite involving the inclusion of acidic polymers to a supersaturated mineralizing solution, in order to induce an amorphous liquid-phase precursor to the inorganic mineral, which is then absorbed (pulled by capillary action) into the organic matrix. Advantageously, once solidified, a high mineral content can be achieved, with the inorganic mineral crystals embedded within the collagen fibers (intrafibrillarly) and oriented such that they are aligned along the long axes of the fibers of the organic matrix, thereby closely mimicking the natural structure of bone. The present invention further concerns a method of treating a patient suffering from a bone defect by applying a biomimetic composite to the bone defect site.

摘要翻译： 本发明涉及一种复合材料，其包含有机流体 - 可溶胀的纤维基质如胶原和矿物相如碳酸钙或磷酸盐矿物相用作骨仿生体。 在另一方面，本发明涉及一种制备涉及将酸性聚合物包含在过饱和矿化溶液中的复合物的方法，以便诱导无机矿物的无定形液相前体，然后将其吸收（通过毛细管作用 ）进入有机基质。 有利地，一旦固化，可以实现高矿物质含量，其中无机矿物晶体嵌入胶原纤维内（纤维内）并定向成使得它们沿着有机基质的纤维的长轴排列，从而紧密地模仿天然 骨结构。 本发明还涉及通过将仿生复合材料应用于骨缺损部位来治疗患有骨缺损的患者的方法。

公开(公告)号：US20050152990A1

公开(公告)日：2005-07-14

申请号：US10819040

申请日：2004-04-05

申请人： Laurie Gower ,  Matthew Olszta

发明人： Laurie Gower ,  Matthew Olszta

IPC分类号： A61K33/42 ,  A61L27/24 ,  A61L27/44 ,  A61L27/46 ,  A61L31/12 ,  A61L31/14

CPC分类号： B82Y30/00 ,  A61K33/42 ,  A61L27/24 ,  A61L27/446 ,  A61L27/46 ,  A61L31/127 ,  A61L31/128 ,  A61L31/146

摘要： The present invention pertains to mineral fibers useful as biomimetics of tissue, such as dental enamel and bone, and as filler in paper, paint, coatings, and plastic production. The present invention also concerns methods for producing mineral fibers by contacting an inorganic liquid-phase mineral precursor with a crystalline inorganic substrate under conditions permitting the inorganic liquid-phase mineral precursor to solidify and crystallize, compositions comprising mineral fibers, and methods for treating a tissue defect within a patient by applying mineral fibers to the site of the tissue defect.

摘要翻译： 本发明涉及可用作组织的生物模拟学的矿物纤维，例如牙釉质和骨，以及作为纸，油漆，涂料和塑料生产中的填料。 本发明还涉及通过使无机液相矿物前体与结晶无机基质在允许无机液相矿物前体固化和结晶的条件下接触而制备矿物纤维的方法，包含矿物纤维的组合物和用于处理组织的方法 通过将矿物纤维施加到组织缺损的部位，患者内的缺损。