Channeled vascular stent apparatus and method
    1.
    发明授权
    Channeled vascular stent apparatus and method 失效
    导管血管支架装置及方法

    公开(公告)号:US06709451B1

    公开(公告)日:2004-03-23

    申请号:US09616274

    申请日:2000-07-14

    IPC分类号: A61F206

    摘要: A vascular stent having one or more channels in the outer surface. The channel(s) provide increased flexibility, enhanced perfusion, increased chronic positional stability, and convenient dispensing of a medication. Preferably the stent is machined into a mesh-like pattern and the channel(s) are machined into the stent elements of the pattern. The channels may be oriented in a variety of ways. Parallel orientation tends to provide greater enhancement of perfusion whereas perpendicular orientation provides differential flexibility. For greater control of differential flexibility, the channel may be further machined in the stent element, producing a regain of greater flexibility.

    摘要翻译: 在外表面具有一个或多个通道的血管支架。 通道提供增加的灵活性,增强的灌注,增加的慢性位置稳定性和方便的药物分配。 优选地,支架被加工成网状图案,并且通道被加工成图案的支架元件。 通道可以以各种方式定向。 平行取向倾向于提供更大的灌注强化,而垂直取向提供差异的灵活性。 为了更好地控制差动柔性,通道可以在支架元件中进一步加工,产生更大灵活性的恢复。

    Heat and mass exchanger
    2.
    发明申请
    Heat and mass exchanger 有权
    热交换器

    公开(公告)号:US20080110191A1

    公开(公告)日:2008-05-15

    申请号:US11818711

    申请日:2007-06-14

    摘要: A mass and heat exchanger includes at least one first substrate with a surface for supporting a continuous flow of a liquid thereon that either absorbs, desorbs, evaporates or condenses one or more gaseous species from or to a surrounding gas; and at least one second substrate operatively associated with the first substrate. The second substrate includes a surface for supporting the continuous flow of the liquid thereon and is adapted to carry a heat exchange fluid therethrough, wherein heat transfer occurs between the liquid and the heat exchange fluid.

    摘要翻译: 质量和热交换器包括至少一个具有用于支撑其上的液体的连续流动的表面的第一基底,其吸收,解吸,蒸发或冷凝来自或周围气体的一种或多种气态物质; 以及至少一个第二基板,其可操作地与所述第一基板相关联。 第二基板包括用于在其上支撑液体的连续流动的表面,并且适于承载通过其中的热交换流体,其中在液体和热交换流体之间发生热传递。

    Solution sandwich hybridization, capture and detection of amplified
nucleic acids
    4.
    发明授权
    Solution sandwich hybridization, capture and detection of amplified nucleic acids 失效
    溶液夹心杂交,扩增核酸的捕获和检测

    公开(公告)号:US5374524A

    公开(公告)日:1994-12-20

    申请号:US53842

    申请日:1993-04-27

    申请人: Jeffrey A. Miller

    发明人: Jeffrey A. Miller

    IPC分类号: C12Q1/68 C12Q1/70 C12P19/34

    CPC分类号: C12Q1/6834 Y10S435/81

    摘要: A nucleic acid probe assay which combines nucleic acid amplification with solution hybridization using capture and reporter probes followed by or simultaneously with immobilization on a solid support is provided. An assay sensitivity equal to 5 copies of HIV I DNA was achieved.

    摘要翻译: 提供了一种核酸探针测定法,其使用捕获和报道探针将核酸扩增与溶液杂交结合在一起,同时固定在固体支持物上。 获得等于5拷贝的HIV I DNA的测定灵敏度。

    Stable and filterable enveloped virus formulations
    6.
    发明授权
    Stable and filterable enveloped virus formulations 有权
    稳定和可过滤的包膜病毒制剂

    公开(公告)号:US07914979B2

    公开(公告)日:2011-03-29

    申请号:US11718348

    申请日:2005-11-04

    IPC分类号: C12Q1/70

    摘要: Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. −20° C.). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.

    摘要翻译: 包膜病毒(例如新城疫病毒(NDV))被配制用于在适度的低温(例如-20℃)下储存。 该制剂是含有浓度为106PFU / mL至1012PFU / mL的包膜病毒的水溶液; 和非还原性糖(例如蔗糖)。 当非还原性糖是二糖时,以5%(w / v)至50%(w / v)的浓度存在于溶液中,当其为单糖时,其存在于溶液中 浓度为2.5%(w / v)至25%(w / v)。 溶液的渗透压为约250mOs以上,pH为5〜10。

    ONCOLYTIC VIRUS THERAPY
    7.
    发明申请
    ONCOLYTIC VIRUS THERAPY 失效
    ONCOLYTIC VIRUS治疗

    公开(公告)号:US20090180994A1

    公开(公告)日:2009-07-16

    申请号:US12412035

    申请日:2009-03-26

    IPC分类号: A61K35/76 A61P35/00

    摘要: A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.

    摘要翻译: 公开了一种用癌症治疗人类受试者的方法。 向受试者施用药物组合物,所述药物组合物包含人白细胞和可复制的溶瘤病毒悬浮于生理学上可接受的溶液中。 或者,药物组合物包含用溶瘤病毒感染的人白细胞或血小板。

    Contact assembly
    9.
    发明授权
    Contact assembly 失效
    接触组件

    公开(公告)号:US07148774B1

    公开(公告)日:2006-12-12

    申请号:US11178839

    申请日:2005-07-11

    IPC分类号: H01H83/00

    CPC分类号: H01H1/22 H01H11/06 H01H73/04

    摘要: A circuit breaker contact assembly includes a line conductor having a folded back fixed contact end, a fixed contact mounted on the contact end, and a movable contact arm having an inner edge and first and second ends. A movable contact is mounted on the first end. The movable contact arm is pivotable about the second end between a closed position in which the inner edge extends adjacent the contact end with the movable contact in contact with the fixed contact to form a reverse current loop, and an open position in which the movable contact is pivoted away from the fixed contact. The contact arm includes a first inner longitudinal member extending along the inner edge and a second outer longitudinal member. The first inner longitudinal member has a higher electrical conductivity than the second outer longitudinal member, which has a higher shear strength and a lower specific density.

    摘要翻译: 断路器触头组件包括具有折回的固定接触端的线路导体,安装在接触端上的固定触点以及具有内边缘和第一端和第二端的可动触头臂。 可移动触点安装在第一端。 所述可动接触臂可围绕所述第二端枢转,所述闭合位置中,所述内边缘与所述接触端相邻延伸,所述可动触头与所述固定触头相接触,以形成反向电流回路;以及打开位置, 枢转远离固定触点。 接触臂包括沿着内边缘延伸的第一内部纵向构件和第二外部纵向构件。 第一内部纵向构件具有比第二外部纵向构件更高的导电性,其具有较高的剪切强度和较低的比重。