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公开(公告)号：US08137663B2
公开(公告)日：2012-03-20
申请号：US12412035
申请日：2009-03-26
CPC分类号： A61K35/768 , A61K35/15 , A61K35/19 , C12N2760/18132 , A61K2300/00
摘要： A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
摘要翻译： 公开了一种用癌症治疗人类受试者的方法。 向受试者施用药物组合物，所述药物组合物包含人白细胞和可复制的溶瘤病毒悬浮于生理学上可接受的溶液中。 或者，药物组合物包含用溶瘤病毒感染的人白细胞或血小板。
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公开(公告)号：US20090180994A1
公开(公告)日：2009-07-16
申请号：US12412035
申请日：2009-03-26
CPC分类号： A61K35/768 , A61K35/15 , A61K35/19 , C12N2760/18132 , A61K2300/00
摘要： A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
摘要翻译： 公开了一种用癌症治疗人类受试者的方法。 向受试者施用药物组合物，所述药物组合物包含人白细胞和可复制的溶瘤病毒悬浮于生理学上可接受的溶液中。 或者，药物组合物包含用溶瘤病毒感染的人白细胞或血小板。
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公开(公告)号：US07595042B2
公开(公告)日：2009-09-29
申请号：US11122690
申请日：2005-05-05
CPC分类号： A61K35/768 , A61K35/15 , A61K35/19 , C12N2760/18132 , A61K2300/00
摘要： A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
摘要翻译： 公开了一种用癌症治疗人类受试者的方法。 向受试者施用药物组合物，所述药物组合物包含人白细胞和可复制的溶瘤病毒悬浮于生理学上可接受的溶液中。 或者，药物组合物包含用溶瘤病毒感染的人白细胞或血小板。
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公开(公告)号：US07122182B2
公开(公告)日：2006-10-17
申请号：US10142405
申请日：2002-05-09
CPC分类号： A61K35/768 , A61K35/15 , A61K35/19 , C12N2760/18132 , A61K2300/00
摘要： A method of treating a human subject with cancer is disclosed. A pharmaceutical composition is administered to the subject, the pharmaceutical composition comprising human leukocytes and a replication-competent oncolytic virus in suspension in a physiologically acceptable solution. Alternatively the pharmaceutical composition comprises human leukocytes or platelets infected with an oncolytic virus.
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公开(公告)号：US20090081161A1
公开(公告)日：2009-03-26
申请号：US12292377
申请日：2008-11-18
申请人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. Von Borstel
发明人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. Von Borstel
CPC分类号： G01N33/5011 , A61K31/4164 , A61K35/76 , A61K38/191 , A61K38/2013 , A61K38/21 , A61K45/06 , A61K2039/505 , C07K16/241 , C12N7/00 , C12N2760/18132 , C12N2760/18151 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
摘要翻译： 本发明涉及能够复制并因此杀死IFN介导的抗病毒应答缺陷的肿瘤细胞的病毒，以及它们在治疗包括癌症和大肿瘤的肿瘤疾病中的用途。 RNA和DNA病毒在这方面是有用的。 本发明还涉及用于癌症治疗的这种病毒的选择，设计，纯化和使用的方法。
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公开(公告)号：US08043612B2
公开(公告)日：2011-10-25
申请号：US12292377
申请日：2008-11-18
申请人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
发明人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
CPC分类号： G01N33/5011 , A61K31/4164 , A61K35/76 , A61K38/191 , A61K38/2013 , A61K38/21 , A61K45/06 , A61K2039/505 , C07K16/241 , C12N7/00 , C12N2760/18132 , C12N2760/18151 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
摘要翻译： 本发明涉及能够复制并因此杀死IFN介导的抗病毒应答缺陷的肿瘤细胞的病毒，以及它们在治疗包括癌症和大肿瘤的肿瘤疾病中的用途。 RNA和DNA病毒在这方面是有用的。 本发明还涉及用于癌症治疗的这种病毒的选择，设计，纯化和使用的方法。
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公开(公告)号：US07780962B2
公开(公告)日：2010-08-24
申请号：US10167652
申请日：2002-06-13
申请人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
发明人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
CPC分类号： G01N33/5011 , A61K35/768 , A61K38/191 , A61K38/2013 , A61K38/21 , A61K39/42 , A61K2039/505 , C07K16/241 , C12N7/00 , C12N2760/18132 , C12N2760/18151 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
摘要翻译： 本发明涉及能够复制并因此杀死IFN介导的抗病毒应答缺陷的肿瘤细胞的病毒，以及它们在治疗包括癌症和大肿瘤的肿瘤疾病中的用途。 RNA和DNA病毒在这方面是有用的。 本发明还涉及用于癌症治疗的这种病毒的选择，设计，纯化和使用的方法。
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公开(公告)号：US08105578B2
公开(公告)日：2012-01-31
申请号：US11698947
申请日：2007-01-29
申请人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
发明人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
CPC分类号： C12N7/00 , A61K35/768 , A61K38/21 , A61K39/42 , C12N2760/18132 , C12N2770/36132 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
摘要翻译： 本发明涉及能够复制并因此杀死IFN介导的抗病毒应答缺陷的肿瘤细胞的病毒，以及它们在治疗包括癌症和大肿瘤的肿瘤疾病中的用途。 RNA和DNA病毒在这方面是有用的。 本发明还涉及用于癌症治疗的这种病毒的选择，设计，纯化和使用的方法。
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公开(公告)号：US07470426B1
公开(公告)日：2008-12-30
申请号：US09958809
申请日：2000-04-17
申请人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
发明人： Michael S. Roberts , Robert M. Lorence , William S. Groene , Harvey Rabin , Reid W. von Borstel
CPC分类号： A61K38/21 , A61K35/768 , C12N2760/18032 , C12N2770/36032 , A61K2300/00
摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
摘要翻译： 本发明涉及能够复制并因此杀死IFN介导的抗病毒应答缺陷的肿瘤细胞的病毒，以及它们在治疗包括癌症和大肿瘤的肿瘤疾病中的用途。 RNA和DNA病毒在这方面是有用的。 本发明还涉及用于癌症治疗的这种病毒的选择，设计，纯化和使用的方法。
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