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24 条记录 (耗时 0.018 秒)

    2-(4-piperidinyl)-1H-pyrido[4,3-b]-indol-1-ones and related compounds
    2.
    发明授权
    2-(4-piperidinyl)-1H-pyrido[4,3-b]-indol-1-ones and related compounds 失效
    2-（4-哌啶基）-1H-吡啶并[4,3-b] - 吲哚-1-酮和相关化合物

    公开(公告)号：US5430154A

    公开(公告)日：1995-07-04

    申请号：US148225

    申请日：1993-11-08

    申请人： Lawrence L. Martin ,  Denise M. Flanagan ,  Joseph F. Payack

    发明人： Lawrence L. Martin ,  Denise M. Flanagan ,  Joseph F. Payack

    IPC分类号： C07D401/12 ,  C07D471/04 ,  C07D401/00 ,  C07D209/42

    CPC分类号： C07D401/12 ,  C07D471/04

    摘要： A compound of the formula ##STR1## wherein R.sup.1 is hydrogen, loweralkyl, phenyl, phenyl substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups, phenylloweralkyl or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; R.sup.2 is loweralkyl, furanylloweralkyl, thienylloweralkyl, pyrrolylloweralkyl, pyridinylloweralkyl, phenylloweralkyl, or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; X is hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl; m is 0 or 1; n is 1 or 2; an optical isomer thereof or a salt thereof.

    摘要翻译： 其中R 1为氢，低级烷基，苯基，被一个或多个低级烷基，低级烷氧基，卤素或三氟甲基取代的苯基，苯基低级烷基或苯基低级烷基，其中苯基被一个或多个低级烷基取代的低级烷氧基 ，卤素或三氟甲基; R2是低级烷基，呋喃基低级烷基，噻吩基低级烷基，吡咯基低级烷基，吡啶基低级烷基，苯基低级烷基或苯基低级烷基，其中苯基被一个或多个低级烷基，低级烷氧基，卤素或三氟甲基取代; X是氢，低级烷基，低级烷氧基，卤素或三氟甲基; m为0或1; n为1或2; 其光学异构体或其盐。

    2-(4-piperidinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
    3.
    发明授权
    2-(4-piperidinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds 失效
    2-（4-哌啶基）-1H-吡啶并[4,3-B]吲哚-1-酮及相关化合物

    公开(公告)号：US5292883A

    公开(公告)日：1994-03-08

    申请号：US67891

    申请日：1993-05-27

    申请人： Lawrence L. Martin ,  Denise M. Flanagan ,  Joseph F. Payack

    发明人： Lawrence L. Martin ,  Denise M. Flanagan ,  Joseph F. Payack

    IPC分类号： C07D401/12 ,  C07D471/04 ,  C07D401/00 ,  C07D209/42

    CPC分类号： C07D401/12 ,  C07D471/04

    摘要： A compound of the formula ##STR1## wherein R.sup.1 is hydrogen, loweralkyl, phenyl, phenyl substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups, phenylloweralkyl or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; R.sup.2 is loweralkyl, furanylloweralkyl, thienylloweralkyl, pyrrolylloweralkyl, pyridinylloweralkyl, phenylloweralkyl, or phenylloweralkyl in which the phenyl group is substituted by one or more loweralkyl, loweralkoxy, halogen, or trifluoromethyl groups; X is hydrogen, loweralkyl, loweralkoxy, halogen, or trifluoromethyl; m is 0, 1 or 2; n is 1 or 2; an optical isomer thereof or a salt thereof.

    摘要翻译： 其中R 1为氢，低级烷基，苯基，被一个或多个低级烷基，低级烷氧基，卤素或三氟甲基取代的苯基，苯基低级烷基或苯基低级烷基，其中苯基被一个或多个低级烷基取代的低级烷氧基 ，卤素或三氟甲基; R2是低级烷基，呋喃基低级烷基，噻吩基低级烷基，吡咯基低级烷基，吡啶基低级烷基，苯基低级烷基或苯基低级烷基，其中苯基被一个或多个低级烷基，低级烷氧基，卤素或三氟甲基取代; X是氢，低级烷基，低级烷氧基，卤素或三氟甲基; m为0,1或2; n为1或2; 其光学异构体或其盐。

    (1,2,3,4-Tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds
    10.
    发明授权
    (1,2,3,4-Tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds 失效
    （1,2,3,4-四氢-9-吖啶亚氨基）环己烷羧酸及相关化合物

    公开(公告)号：US5126449A

    公开(公告)日：1992-06-30

    申请号：US788079

    申请日：1991-11-05

    申请人： Lawrence L. Martin ,  Joseph F. Payack ,  Helen H. Ong

    发明人： Lawrence L. Martin ,  Joseph F. Payack ,  Helen H. Ong

    IPC分类号： C07D219/10 ,  C07D413/04

    CPC分类号： C07D413/04 ,  C07D219/10

    摘要： There are described compounds of the formula, ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;R when present is hydrogen, loweralkyl or arylloweralkyl;R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; andR.sub.2 when present is hydrogen or loweralkyl; which compounds are useful for alleviating various memory dysfunctions characterized by a decreased cholinergic function such Alzheimer's disease.

    摘要翻译： 描述了下式的化合物，其中X是氢，低级烷基，低级烷氧基或卤素; 存在时R为氢，低级烷基或芳基低级烷基; R1是氢，低级烷基或芳基低级烷基; 当R 2为氢或低级烷基时; 哪些化合物可用于缓解以胆碱能功能降低为特征的各种记忆功能障碍，如阿尔茨海默氏病。