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1.发明授权(1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds 失效（1,2,3,4-四氢-9-吖啶亚氨基）环己烷羧酸及相关化合物
公开(公告)号：US4999358A
公开(公告)日：1991-03-12
申请号：US371228
申请日：1989-06-26
IPC分类号： A61K31/47 , A61K31/473 , A61K31/535 , A61P25/28 , C07D219/10 , C07D413/04
CPC分类号： C07D413/04 , C07D219/10
摘要： There are described compounds of the formula, ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;R when present is hydrogen, loweralkyl or arylloweralkyl;R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; andR.sub.2 when present is hydrogen or loweralkyl;which compounds are useful for alleviating various memory dysfunctions characterized by a decreased cholinergic function such Alzheimer's disease.
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2.发明授权(1,2,3,4-Tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds 失效（1,2,3,4-四氢-9-吖啶亚氨基）环己烷羧酸及相关化合物
公开(公告)号：US5126449A
公开(公告)日：1992-06-30
申请号：US788079
申请日：1991-11-05
IPC分类号： C07D219/10 , C07D413/04
CPC分类号： C07D413/04 , C07D219/10
摘要： There are described compounds of the formula, ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;R when present is hydrogen, loweralkyl or arylloweralkyl;R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; andR.sub.2 when present is hydrogen or loweralkyl; which compounds are useful for alleviating various memory dysfunctions characterized by a decreased cholinergic function such Alzheimer's disease.
摘要翻译： 描述了下式的化合物，其中X是氢，低级烷基，低级烷氧基或卤素; 存在时R为氢，低级烷基或芳基低级烷基; R1是氢，低级烷基或芳基低级烷基; 当R 2为氢或低级烷基时; 哪些化合物可用于缓解以胆碱能功能降低为特征的各种记忆功能障碍，如阿尔茨海默氏病。
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3.发明授权Process for (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds 失效（1,2,3,4-四氢-9-吖啶亚氨基）环己烷羧酸及相关化合物的方法
公开(公告)号：US5149813A
公开(公告)日：1992-09-22
申请号：US858721
申请日：1992-03-27
IPC分类号： C07D219/10 , C07D413/04
CPC分类号： C07D413/04 , C07D219/10
摘要： There are described compounds of the formula, ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;R when present is hydrogen, loweralkyl or arylloweralkyl;R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; andR.sub.2 when present is hydrogen or loweralkyl;which compounds are useful for alleviating various memory dysfunctions characterized by a decreased cholinergic function such Alzheimer's disease.
摘要翻译： 描述了下式的化合物，其中X是氢，低级烷基，低级烷氧基或卤素; 存在时R为氢，低级烷基或芳基低级烷基; R1是氢，低级烷基或芳基低级烷基; 当R 2为氢或低级烷基时; 哪些化合物可用于缓解以胆碱能功能降低为特征的各种记忆功能障碍，如阿尔茨海默氏病。
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4.发明授权Compound, 5,6,7,8-tetrahydro-1-(1,2,3,4-acridin-9-yl)-2H-3,1-benzoxazine-2,4-(1H)d ione 失效化合物5,6,7,8-四氢-1-（1,2,3,4-吖啶-9-基）-2H-3,1-苯并恶嗪-2,4-（1H）二酮
公开(公告)号：US5089615A
公开(公告)日：1992-02-18
申请号：US640348
申请日：1991-01-11
IPC分类号： C07D219/10 , C07D413/04
CPC分类号： C07D413/04 , C07D219/10
摘要： There are described compounds of the formula ##STR1## where X is hydrogen, loweralkyl, loweralkoxy or halogen;R when present is hydrogen, loweralkyl or aryloweralkyl;R.sub.1 is hydrogen, loweralkyl or arylloweralkyl; andR.sub.2 when present is hydrogen or loweralkyl;which compounds are useful for alleviating various memory dysfunctions characterized by a decreased cholinergic function such Alzheimer's disease.
摘要翻译： 描述了式（I）的化合物，其中X是氢，低级烷基，低级烷氧基或卤素; 存在时R为氢，低级烷基或芳基烷基; R1是氢，低级烷基或芳基低级烷基; 当R 2为氢或低级烷基时; 哪些化合物可用于缓解以胆碱能功能降低为特征的各种记忆功能障碍，如阿尔茨海默氏病。
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5.发明授权Antidepressant (.alpha.-phenyl-2-tolyl)azacycloalkanols and derivatives thereof 失效抗抑郁药（α-苯基-2-甲苯基）氮杂环烷醇及其衍生物
公开(公告)号：US4414219A
公开(公告)日：1983-11-08
申请号：US174435
申请日：1980-08-01
IPC分类号： C07D207/12 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/52 , C07D211/70 , C07D211/94 , A61K31/445 , A61K31/40 , C07D211/42
CPC分类号： C07D211/22 , C07D207/12 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/52 , C07D211/70 , C07D211/94
摘要： Novel azacycloalkanes, azacycloalkenes and derivatives thereof and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants, tranquilizers and analgetics.
摘要翻译： 描述了新的氮杂环烷烃，氮杂环烯烃及其衍生物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药，止痛药和止痛药。
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6.发明授权Antidepressant and tranquilizing (.alpha.-phenyl-2-tolyl)-azacycloalkenes 失效抗抑郁药和镇静药（α-苯基-2-甲苯基） - 氮杂环烯烃
公开(公告)号：US4311703A
公开(公告)日：1982-01-19
申请号：US174450
申请日：1980-08-01
IPC分类号： C07D207/12 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/52 , C07D211/70 , C07D211/94 , A61K31/44 , A61K31/40 , C07D207/20
CPC分类号： C07D207/12 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/52 , C07D211/70 , C07D211/94
摘要： Novel azacycloalkanes, azacycloalkenes and derivatives thereof and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants, tranquilizers and analgetics.
摘要翻译： 描述了新的氮杂环烷烃，氮杂环烯烃及其衍生物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药，止痛药和止痛药。
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公开(公告)号：US4241071A
公开(公告)日：1980-12-23
申请号：US6791
申请日：1979-01-25
IPC分类号： C07D207/12 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/52 , C07D211/70 , C07D211/94 , A61K31/445 , A61K31/40 , C07D211/10
CPC分类号： C07D211/22 , C07D207/12 , C07D211/12 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/52 , C07D211/70 , C07D211/94
摘要： Novel azacycloalkanes, azacycloalkenes and derivatives thereof and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants, tranquilizers and analgetics.
摘要翻译： 描述了新的氮杂环烷烃，氮杂环烯烃及其衍生物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药，止痛药和止痛药。
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8.发明授权Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds 失效取代的1,2,3,4-四氢环戊二烯[b]吲哚，1,2,3,3a，4,8a-六氢环戊二烯并[b]吲哚和相关化合物
公开(公告)号：US5472975A
公开(公告)日：1995-12-05
申请号：US177035
申请日：1994-01-04
IPC分类号： A61K31/40 , C07D209/80 , C07D209/94 , C07D209/88
CPC分类号： C07D209/80
摘要： There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
摘要翻译： 公开了下列通式的各种化合物，其中n，X和R 1至R 4如说明书中所定义，其可用于缓解以胆碱能缺乏为特征的各种记忆功能障碍如阿尔茨海默氏病。 本发明的化合物还抑制单胺氧化酶和/或作用于中枢性α2-肾上腺素能受体，因此可用作抗抑郁药。
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公开(公告)号：US5334715A
公开(公告)日：1994-08-02
申请号：US986415
申请日：1993-02-01
申请人： Helen H. Ong , Nicholas J. Hrib , Joseph Perez , John G. Jurcak
发明人： Helen H. Ong , Nicholas J. Hrib , Joseph Perez , John G. Jurcak
IPC分类号： A61K31/495 , A61P25/18 , C07D209/48 , C07D221/20 , C07D239/42 , C07D277/14 , C07D277/20 , C07D277/34 , C07D295/12 , C07D295/125 , C07D401/12 , C07D403/12 , C07D409/00 , C07D409/12 , C07D417/12 , C07D471/04 , C07D295/00 , C07D401/00 , C07D403/00 , C07D413/00
CPC分类号： C07D209/48 , C07D221/20 , C07D239/42 , C07D277/34 , C07D295/125 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/04
摘要： Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.
摘要翻译： 公开了新颖的1-哌嗪基-2-丁烯和-2-丁炔，其制备方法及其制备方法，以及利用化合物或其组合物治疗精神病的方法。
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公开(公告)号：US5140027A
公开(公告)日：1992-08-18
申请号：US522932
申请日：1990-05-14
IPC分类号： C07D313/14
CPC分类号： C07D313/14
摘要： Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.
摘要翻译： 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。
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