公开(公告)号：US07655468B2

公开(公告)日：2010-02-02

申请号：US11943434

申请日：2007-11-20

申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： C12N15/88 ,  A61K31/70 ,  A61K9/127

CPC分类号： A61K47/48315 ,  A61K9/1272 ,  A61K47/543 ,  A61K47/645 ,  C12N15/88

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物浓度多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US07361640B2

公开(公告)日：2008-04-22

申请号：US10426220

申请日：2003-04-29

申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： A61K31/715 ,  A61K9/127 ,  C12N15/88 ,  C07H21/02 ,  C07K17/00

CPC分类号： C12N15/88 ,  A61K9/1272

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

公开(公告)号：US20120178702A1

公开(公告)日：2012-07-12

申请号：US13189082

申请日：2011-07-22

申请人： Leaf HUANG ,  Xiang Gao ,  Frank L. Sorgi

发明人： Leaf HUANG ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： A61K38/14 ,  C12N5/071 ,  C07K14/00

CPC分类号： A61K47/543 ,  A61K9/1272 ,  A61K47/645 ,  C12N15/88

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US07993672B2

公开(公告)日：2011-08-09

申请号：US12637544

申请日：2009-12-14

申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： A61K9/127 ,  A61K38/00 ,  C07H21/04

CPC分类号： A61K47/48315 ,  A61K9/1272 ,  A61K47/543 ,  A61K47/645 ,  C12N15/88

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US07335509B2

公开(公告)日：2008-02-26

申请号：US11014528

申请日：2004-12-15

申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： C12N15/88 ,  A61K31/70 ,  A61K9/127

CPC分类号： C12N15/88 ,  A61K9/1272

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US06008202A

公开(公告)日：1999-12-28

申请号：US939874

申请日：1997-09-29

申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi ,  Ralph Wilfred Paul ,  David L. Sloane ,  Aaron Garth Loomis

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi ,  Ralph Wilfred Paul ,  David L. Sloane ,  Aaron Garth Loomis

IPC分类号： A61K9/127 ,  C12N15/88 ,  A61K31/00 ,  A61K48/00

CPC分类号： C12N15/88 ,  A61K9/1272

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US20080153166A1

公开(公告)日：2008-06-26

申请号：US11943434

申请日：2007-11-20

申请人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

发明人： Leaf Huang ,  Xiang Gao ,  Frank L. Sorgi

IPC分类号： C12N15/88 ,  C12N15/11 ,  C07K14/00 ,  C07K11/00

CPC分类号： A61K47/48315 ,  A61K9/1272 ,  A61K47/543 ,  A61K47/645 ,  C12N15/88

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US5795587A

公开(公告)日：1998-08-18

申请号：US376701

申请日：1995-01-23

申请人： Xiang Gao ,  Leaf Huang

发明人： Xiang Gao ,  Leaf Huang

IPC分类号： A61K9/127 ,  A61K48/00 ,  C12N15/88

CPC分类号： A61K47/48315 ,  A61K47/48046 ,  A61K9/1272 ,  C12N15/88

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the components of the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 生产的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物的组分浓度多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US20050152964A1

公开(公告)日：2005-07-14

申请号：US11014528

申请日：2004-12-15

申请人： Leaf Huang ,  Xiang Gao ,  Frank Sorgi ,  Ralph Paul ,  David Sloane ,  Aaron Loomis

发明人： Leaf Huang ,  Xiang Gao ,  Frank Sorgi ,  Ralph Paul ,  David Sloane ,  Aaron Loomis

IPC分类号： A61K9/127 ,  C12N15/88 ,  A61K48/00

CPC分类号： C12N15/88 ,  A61K9/1272

摘要： Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

摘要翻译： 描述了新的稳定的，浓缩的，生物活性的和即用型含脂质的药物递送复合物及其生产方法。 所生成的络合物的生物活性与根据现有技术的混合方法制备的制剂相当，并且在纯化后，通过本发明的方法制备的络合物比通过混合物形成的络合物多50至500倍。 本文所述的方法提供大规模生产用于基因治疗和其它应用的含脂质药物递送系统。

公开(公告)号：US09494532B2

公开(公告)日：2016-11-15

申请号：US13240632

申请日：2011-09-22

申请人： Binglong Xie ,  Yakup Genc ,  Xiang Gao

发明人： Binglong Xie ,  Yakup Genc ,  Xiang Gao

IPC分类号： G01N21/95 ,  G01B11/245 ,  G01N21/954 ,  G06T7/00

CPC分类号： G01N21/9515 ,  G01B11/245 ,  G01N21/954 ,  G06T7/001 ,  G06T2200/24 ,  G06T2207/30164

摘要： Systems and methods for inspecting a device include arranging the device in a known position relative to a plurality of movable cameras mounted on a controllable actuator controlled by a computing device and pointed at the device by controlling the controllable actuator to position a camera with a user interface on the computing device with a display, and the display displays a virtual image from the camera into CAD model of the device and an image of the device generated by the camera in a side-by-side or in an overlay fashion or both.

摘要翻译： 用于检查设备的系统和方法包括将设备布置在相对于安装在由计算设备控制的可控制致动器上的多个可移动摄像机的已知位置，并通过控制可控致动器来定位具有用户界面的摄像机 在具有显示器的计算设备上，并且显示器将来自相机的虚拟图像显示为设备的CAD模型和由相机以并排或叠加方式或两者均生成的设备的图像。