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1.发明授权Methods and compositions for modulating an immune response with immunogenic oligonucleotides 有权用免疫原性寡核苷酸调控免疫应答的方法和组合物公开(公告)号：US08241844B2
公开(公告)日：2012-08-14
申请号：US12572494
申请日：2009-10-02
申请人： Lee A. Bulla, Jr. , Jeffrey Marcus Clark , Ralph Clark, legal representative , Natalya Griko , Jian Sun
CPC分类号： A61K31/711 , A61K39/39 , A61K2039/55561 , C07H21/04 , C07K14/005 , C12N2740/15022 , C12N2740/16022 , Y02A50/41 , Y02A50/412
摘要： This document relates to compositions and methods for modulating an immune response. For example, compositions of immunostimulatory CpG oligonucleotides derived from retroviral genomes are provided.
摘要翻译： 本文件涉及用于调节免疫应答的组合物和方法。 例如，提供了衍生自逆转录病毒基因组的免疫刺激性CpG寡核苷酸的组合物。
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2.发明申请公开(公告)号：US20130004538A1
公开(公告)日：2013-01-03
申请号：US13544129
申请日：2012-07-09
CPC分类号： A61K31/711 , A61K39/39 , A61K2039/55561 , C07H21/04 , C07K14/005 , C12N2740/15022 , C12N2740/16022 , Y02A50/41 , Y02A50/412
摘要： This document relates to compositions and methods for modulating an immune response. For example, compositions of immunostimulatory CpG oligonucleotides derived from retroviral genomes are provided.
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3.发明申请METHODS AND COMPOSITIONS FOR MODULATING AN IMMUNE RESPONSE WITH IMMUNOGENIC OLIGONUCLEOTIDES 有权用免疫原性寡核苷酸调节免疫应答的方法和组合物公开(公告)号：US20100119556A1
公开(公告)日：2010-05-13
申请号：US12572494
申请日：2009-10-02
CPC分类号： A61K31/711 , A61K39/39 , A61K2039/55561 , C07H21/04 , C07K14/005 , C12N2740/15022 , C12N2740/16022 , Y02A50/41 , Y02A50/412
摘要： This document relates to compositions and methods for modulating an immune response. For example, compositions of immunostimulatory CpG oligonucleotides derived from retroviral genomes are provided.
摘要翻译： 本文件涉及用于调节免疫应答的组合物和方法。 例如，提供了衍生自逆转录病毒基因组的免疫刺激性CpG寡核苷酸的组合物。
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4.发明授权Methods and compositions for modulating an immune response with immunogenic oligonucleotides 有权用免疫原性寡核苷酸调节免疫应答的方法和组合物公开(公告)号：US09051360B2
公开(公告)日：2015-06-09
申请号：US13544129
申请日：2012-07-09
申请人： Lee A. Bulla, Jr. , Natalya Griko , Jian Sun , Ralph Clark
IPC分类号： A61K39/00 , C12N15/11 , C12N15/117 , C07K14/005 , A61K39/39
CPC分类号： A61K31/711 , A61K39/39 , A61K2039/55561 , C07H21/04 , C07K14/005 , C12N2740/15022 , C12N2740/16022 , Y02A50/41 , Y02A50/412
摘要： This document relates to compositions and methods for modulating an immune response. For example, compositions of immunostimulatory CpG oligonucleotides derived from retroviral genomes are provided.
摘要翻译： 本文件涉及用于调节免疫应答的组合物和方法。 例如，提供了衍生自逆转录病毒基因组的免疫刺激性CpG寡核苷酸的组合物。
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5.发明申请METHODS AND COMPOSITIONS FOR MODULATING AN IMMUNE RESPONSE WITH IMMUNOGENIC OLIGONUCLEOTIDES 审中-公开用免疫原性寡核苷酸调节免疫应答的方法和组合物公开(公告)号：US20150342980A1
公开(公告)日：2015-12-03
申请号：US14733318
申请日：2015-06-08
申请人： Lee A. BULLA, JR. , Natalya Griko , Jian Sun
IPC分类号： A61K31/711 , C07H21/04 , A61K39/39
CPC分类号： A61K31/711 , A61K39/39 , A61K2039/55561 , C07H21/04 , C07K14/005 , C12N2740/15022 , C12N2740/16022 , Y02A50/41 , Y02A50/412
摘要： This document relates to compositions and methods for modulating an immune response. For example, compositions of immunostimulatory CpG oligonucleotides derived from retroviral genomes are provided.
摘要翻译： 本文件涉及用于调节免疫应答的组合物和方法。 例如，提供了衍生自逆转录病毒基因组的免疫刺激性CpG寡核苷酸的组合物。
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6.发明申请公开(公告)号：US20130297640A1
公开(公告)日：2013-11-07
申请号：US13922542
申请日：2013-06-20
申请人： Jeffrey Marcus Clark
发明人： Jeffrey Marcus Clark
IPC分类号： G06F19/22
摘要： A system and method for performing non-binary comparison of biological sequences includes a new measure ω0, which is a non-binary counting measure that is used in a stand alone module called VaSSA-1. This measure obtains substantially more information about sequences and comparisons between them than is gathered by conventional bioinformatics techniques.
摘要翻译： 用于执行生物序列的非二进制比较的系统和方法包括新的测量值omega0，其是在称为VaSSA-1的独立模块中使用的非二进制计数度量。 这一措施比传统的生物信息学技术所收集到的更多关于它们之间序列和比较的信息。
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