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1.
公开(公告)号:US08735405B2
公开(公告)日:2014-05-27
申请号:US13446629
申请日:2012-04-13
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew P. Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew P. Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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2.
公开(公告)号:US07820662B2
公开(公告)日:2010-10-26
申请号:US12244947
申请日:2008-10-03
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Arno G. Steinig , Yingchuan Sun , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: C07D487/00 , A01N43/64
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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公开(公告)号:US20090118499A1
公开(公告)日:2009-05-07
申请号:US12244947
申请日:2008-10-03
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Quinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: C07D487/04
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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4.
公开(公告)号:US08101613B2
公开(公告)日:2012-01-24
申请号:US12540047
申请日:2009-08-12
申请人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
发明人: Lee D. Arnold , Cara Cesario , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark J. Mulvihill , Anthony I. Nigro , Bijoy Panicker , Amo G. Steinig , Yingchuan Sun , Qinghua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang
IPC分类号: A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D471/00 , C07D487/00
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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公开(公告)号:US20120196847A1
公开(公告)日:2012-08-02
申请号:US13446629
申请日:2012-04-13
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: A61K31/4985 , A61K31/53 , A61P35/00 , A61K31/5377 , A61K31/551 , C07D487/04 , A61K31/519
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
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6.
公开(公告)号:US20120077979A1
公开(公告)日:2012-03-29
申请号:US13308694
申请日:2011-12-01
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: C07D487/04 , C07F5/02
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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7.
公开(公告)号:US20090325928A1
公开(公告)日:2009-12-31
申请号:US12540047
申请日:2009-08-12
申请人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人: Lee D. Arnold , Heather Coate , Andrew Philip Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Michelle Mulvihill , Mark Joseph Mulvihill , Anthony Nigro , Bijoy Panicker , Arno G. Steinig , Qingua Weng , Douglas S. Werner , Michael J. Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号: C07D471/04 , A61K31/495 , A61K31/519 , A61K31/5377 , A61K31/551 , A61P35/04
CPC分类号: C07F5/025 , C07D471/04 , C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译: 其中X 1,X 2,X 3,X 4,X 5,X 6,X 7,R 1和Q 1在本文中定义的式及其药学上可接受的盐的化合物抑制IGF-1R酶,并且可用于治疗和/或预防 过度增生性疾病如癌症,炎症,牛皮癣,过敏/哮喘,免疫系统的疾病和状况,中枢神经系统的疾病和状况。
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