公开(公告)号：US4980283A

公开(公告)日：1990-12-25

申请号：US360626

申请日：1989-06-02

申请人： Leeyuan Huang ,  Joseph Dunn, Jr. ,  Lawrence Koupal ,  Jerrold Liesch ,  Otto Hensens ,  H. Boyd Woodruff

发明人： Leeyuan Huang ,  Joseph Dunn, Jr. ,  Lawrence Koupal ,  Jerrold Liesch ,  Otto Hensens ,  H. Boyd Woodruff

IPC分类号： C07K5/02 ,  C12P21/04

CPC分类号： C07K5/0205 ,  Y10S435/898 ,  Y10S530/86

摘要： A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.

摘要翻译： 胃蛋白酶抑制剂A的苯基衍生物，其在抑制肾素酶活性方面比胃酶抑素更有效，并且与胃蛋白酶抑制相比，对于肾素相对于胃蛋白酶抑制具有显着更高的选择性，其可用于治疗高血压和充血性心力衰竭。

公开(公告)号：US4874745A

公开(公告)日：1989-10-17

申请号：US103324

申请日：1987-10-01

申请人： Leeyuan Huang ,  Lawrence Koupal ,  Joseph Dunn, Jr. ,  Jerrold M. Liesch ,  Otto Hensens ,  H. Boyd Woodruff

发明人： Leeyuan Huang ,  Lawrence Koupal ,  Joseph Dunn, Jr. ,  Jerrold M. Liesch ,  Otto Hensens ,  H. Boyd Woodruff

IPC分类号： C07K5/02

CPC分类号： C07K5/0205 ,  Y10S530/86

摘要： A phenyl derivative of pepstatin A, which is much more potent than pepstatin in inhibiting renin enzyme activity and has significantly greater selectivity for renin over pepsin inhibition than does pepstatin, which is useful in treating hypertension and congestive heart failure.

摘要翻译： 胃蛋白酶抑制剂A的苯基衍生物，其在抑制肾素酶活性方面比胃酶抑素更有效，并且与胃蛋白酶抑制相比，胃蛋白酶抑制的选择性比胃蛋白酶明显更高，其可用于治疗高血压和充血性心力衰竭。

公开(公告)号：US5091389A

公开(公告)日：1992-02-25

申请号：US690407

申请日：1991-04-23

申请人： John Ondeyka ,  Otto Hensens ,  Jerrold Liesch

发明人： John Ondeyka ,  Otto Hensens ,  Jerrold Liesch

IPC分类号： A61K31/435 ,  A61P31/04 ,  A61P37/06 ,  C07D498/18 ,  C12P17/18 ,  C12R1/55

CPC分类号： C07D498/18

摘要： Disclosed is a novel lipophilic macrolide of assigned Formula I: ##STR1## The compound of assigned Formula I is an analog of rapamycin which has activity as an antifungal agent and as an immunosuppressant.

公开(公告)号：US5093338A

公开(公告)日：1992-03-03

申请号：US690410

申请日：1991-04-23

申请人： Kevin Byrne ,  Robert T. Goegelman ,  Otto Hensens ,  Louis Kaplan ,  Jerrold M. Liesch

发明人： Kevin Byrne ,  Robert T. Goegelman ,  Otto Hensens ,  Louis Kaplan ,  Jerrold M. Liesch

IPC分类号： A61K31/445 ,  A61P31/04 ,  A61P37/06 ,  C07D498/18 ,  C12P17/18 ,  C12R1/55

CPC分类号： C07D498/18 ,  C12P17/188

摘要： Disclosed is a novel lipophilic macrolide of Formula I: ##STR1## The compound of assigned Formula I is an analog of rapamycin which has activity as an antifungal agent and as an immunosuppressant.