公开(公告)号：US09778248B2

公开(公告)日：2017-10-03

申请号：US14835834

申请日：2015-08-26

Applicant: Leibniz—Institut fuer Analytische Wissenschaften—ISAS—e.V.

Inventor： Jonathan West ,  Dirk Janasek ,  Albert Sickmann

IPC: G01N33/50 ,  G01N15/10 ,  G01N33/49 ,  G01N27/447

CPC classification number: G01N33/5032 ,  G01N15/10 ,  G01N27/447 ,  G01N33/4915 ,  G01N2015/1006

Abstract: With a method for measurement of thrombocyte function, a solution is created, by which the sensitivity of individual thrombocytes can be measured with the least possible apparatus effort, with high throughput, by passing a liquid thrombocyte solution, in which the thrombocytes are present in isolated form, into a microfluidic chamber and brought into contact with at least one stimulant, wherein an electrical field directed transverse to the entry direction of the thrombocyte solution is applied to the chamber, and the movement path of the thrombocytes in the electrical field is observed and evaluated, in such a manner that thrombocytes having a movement path directed in the direction toward the minus pole of the electrical field are classified as non-activated thrombocytes, and thrombocytes having a movement path directed in the direction toward the plus pole of the electrical field are classified as activated thrombocytes.