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1.发明授权Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效用于制备具有回肠胆汁酸运输抑制剂和牛磺胆酸摄取作用的苯并噻吩类的中间体和方法公开(公告)号：US06262277B1
公开(公告)日：2001-07-17
申请号：US09443403
申请日：1999-11-19
申请人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： C07D33700
CPC分类号： A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译： 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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2.发明授权Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效具有作为回肠胆汁酸转运抑制剂和牛磺胆酸摄取的活性的苯并噻庚英公开(公告)号：US06387924B2
公开(公告)日：2002-05-14
申请号：US09828968
申请日：2001-04-09
申请人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： A61K3144
CPC分类号： A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译： 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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3.发明授权Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效具有作为回肠胆汁酸转运抑制剂和牛磺胆酸摄取的活性的5-取代的5-芳基 - 苯并噻吖庚因
公开(公告)号：US6107494A
公开(公告)日：2000-08-22
申请号：US275463
申请日：1999-03-24
申请人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： A61K31/38 , C07C319/14 , C07C323/12 , C07C323/18 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/6553 , C07K5/068 , C08G65/329 , C07D337/00 , A61K31/495 , C07D487/00
CPC分类号： C07K5/06086 , A61K31/38 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C08G65/329
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译： 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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4.发明授权
公开(公告)号：US5994391A
公开(公告)日：1999-11-30
申请号：US109551
申请日：1998-07-02
申请人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： A61K31/00 , A61K31/38 , A61K31/4035 , A61K31/41 , A61K31/4178 , A61K31/4433 , A61K31/4436 , A61K31/4709 , A61K31/4995 , A61K31/662 , A61K31/67 , A61P1/16 , A61P3/06 , A61P9/10 , A61P43/00 , C07B53/00 , C07C319/14 , C07C323/12 , C07C323/18 , C07C323/19 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/653 , C07F9/6553 , C07K5/06 , C07K5/068 , C08G65/329 , A61K31/44 , C07D211/72 , C07D337/00
CPC分类号： A61K31/38 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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5.发明授权Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效具有作为回肠胆汁酸转运抑制剂和牛磺胆酸摄取的活性的苯并噻庚英公开(公告)号：US06784201B2
公开(公告)日：2004-08-31
申请号：US10068297
申请日：2002-02-08
申请人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
发明人： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC分类号： A61K3138
CPC分类号： A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
摘要： Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
摘要翻译： 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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