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1.发明授权Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG CO-A reductase inhibitors 失效使用回肠胆汁酸转运抑制苯并噻二嗪和HMG CO-A还原酶抑制剂的联合治疗公开(公告)号：US06943189B2
公开(公告)日：2005-09-13
申请号：US10620460
申请日：2003-07-17
Applicant: Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
Inventor： Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
IPC: A61K31/22 , A61K31/366 , A61K31/38 , A61K31/405 , A61K45/06 , C07D337/06 , C07D337/08 , C07D409/10 , C07D495/04 , C07D495/10 , C08G65/329 , A01N43/02 , C07D337/00
CPC classification number: C08G65/329 , A61K31/22 , A61K31/366 , A61K31/38 , A61K31/405 , A61K45/06 , C07D337/06 , C07D337/08 , C07D409/10 , C07D495/04 , C07D495/10 , A61K2300/00
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
Abstract translation: 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。 还提供了使用回肠胆汁酸转运抑制剂和HMG Co-A还原酶抑制剂联合治疗高脂血症的组合物和方法。
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2.发明授权Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效用于制备具有回肠胆汁酸运输抑制剂和牛磺胆酸摄取作用的苯并噻吩类的中间体和方法公开(公告)号：US06262277B1
公开(公告)日：2001-07-17
申请号：US09443403
申请日：1999-11-19
Applicant: Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
Inventor： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC: C07D33700
CPC classification number: A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
Abstract translation: 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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3.发明申请Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors 失效使用回肠胆汁酸转运抑制苯并噻二嗪和HMG Co-A还原酶抑制剂的联合治疗公开(公告)号：US20040157915A1
公开(公告)日：2004-08-12
申请号：US10620460
申请日：2003-07-17
Applicant: G.D. Searle & Co.
Inventor： Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
IPC: A61K031/675 , A61K031/38
CPC classification number: C08G65/329 , A61K31/22 , A61K31/366 , A61K31/38 , A61K31/405 , A61K45/06 , C07D337/06 , C07D337/08 , C07D409/10 , C07D495/04 , C07D495/10 , A61K2300/00
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
Abstract translation: 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。 还提供了使用回肠胆汁酸转运抑制剂和HMG Co-A还原酶抑制剂联合治疗高脂血症的组合物和方法。
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公开(公告)号：US06642268B2
公开(公告)日：2003-11-04
申请号：US10076091
申请日：2002-02-15
Applicant: Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
Inventor： Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
IPC: A61K3138
CPC classification number: C08G65/329 , A61K31/22 , A61K31/366 , A61K31/38 , A61K31/405 , A61K45/06 , C07D337/06 , C07D337/08 , C07D409/10 , C07D495/04 , C07D495/10 , A61K2300/00
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co—A reductase inhibitors for the treatment of hyperlipidemic conditions.
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5.发明授权Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors 失效使用回肠胆汁酸转运抑制苯并噻二嗪和HMG Co-A还原酶抑制剂的联合治疗公开(公告)号：US06420417B1
公开(公告)日：2002-07-16
申请号：US09676466
申请日：2000-09-29
Applicant: Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
Inventor： Bradley T. Keller , Kevin C. Glenn , Robert E. Manning
IPC: A61K3138
CPC classification number: C07D495/04 , A61K31/22 , A61K31/366 , A61K31/38 , A61K31/405 , A61K45/06 , C07D337/06 , C07D337/08 , C07D409/10 , C07D495/10 , C08G65/329 , A61K2300/00
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.
Abstract translation: 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。 还提供了使用回肠胆汁酸转运抑制剂和HMG Co-A还原酶抑制剂联合治疗高脂血症的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US3950425A
公开(公告)日：1976-04-13
申请号：US463636
申请日：1974-04-24
Applicant: Willem Jacob van der Burg
Inventor： Willem Jacob van der Burg
IPC: C07D295/02 , C07C67/00 , C07C209/00 , C07C209/24 , C07C209/40 , C07C209/50 , C07C211/27 , C07C213/00 , C07C215/64 , C07C217/74 , C07C313/00 , C07C323/31 , C07D223/22 , C07D313/06 , C07D313/14 , C07D337/06 , C07D401/06 , C07D413/06 , C07C87/28 , C07C87/64
CPC classification number: C07D401/06 , C07D223/22 , C07D313/06 , C07D337/06 , C07D413/06
Abstract: The invention discloses novel compounds of the general formula: ##SPC1##And salts thereof,In whichX stands for oxygen, sulphur, the group >NR.sub.7 or the group --CR.sub.8 R.sub.9 --;R.sub.1, r.sub.2, r.sub.3 and R.sub.4 represent hydrogen, hydroxy, halogen, alkyl (1-6 C), alkoxy (1-6 C), alkylthio (1-6 C) or trifluoromethyl;R.sub.5 and R.sub.6 represent hydrogen, alkyl (1-6 C), aralkyl (7-10 C) or together in combination with the nitrogen atom a heterocyclic five- or six-membered ring;R.sub.7 stands for hydrogen or alkyl (1-4 C);R.sub.8 and R.sub.9 stands for hydrogen or methyl,n is the number 0, 1 or 2 andThe dotted line means an optional C-C bond,With valuable central nervous system (CNS) activites, especially antidepressant activity.The invention further discloses novel intermediates of the general formula: ##SPC2##As well as biologically active intermediates of the formula: ##SPC3##As well as salts and esters thereof.
Abstract translation: 本发明公开了以下通式的新化合物：
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7.发明授权Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效具有作为回肠胆汁酸转运抑制剂和牛磺胆酸摄取的活性的苯并噻庚英公开(公告)号：US06387924B2
公开(公告)日：2002-05-14
申请号：US09828968
申请日：2001-04-09
Applicant: Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
Inventor： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC: A61K3144
CPC classification number: A61K31/38 , B24B5/18 , B24B21/12 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329 , C07C323/12 , C07C323/18
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
Abstract translation: 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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8.发明授权Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake 失效具有作为回肠胆汁酸转运抑制剂和牛磺胆酸摄取的活性的5-取代的5-芳基 - 苯并噻吖庚因
公开(公告)号：US6107494A
公开(公告)日：2000-08-22
申请号：US275463
申请日：1999-03-24
Applicant: Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
Inventor： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC: A61K31/38 , C07C319/14 , C07C323/12 , C07C323/18 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/6553 , C07K5/068 , C08G65/329 , C07D337/00 , A61K31/495 , C07D487/00
CPC classification number: C07K5/06086 , A61K31/38 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C08G65/329
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
Abstract translation: 提供了新的苯并噻庚因，衍生物和类似物; 含有它们的药物组合物; 以及在医学中使用这些化合物和组合物的方法，特别是用于预防和治疗哺乳动物中高脂血症的疾病，例如与动脉粥样硬化或高胆固醇血症有关的那些。
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9.发明授权
公开(公告)号：US5994391A
公开(公告)日：1999-11-30
申请号：US109551
申请日：1998-07-02
Applicant: Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
Inventor： Len F. Lee , Shyamal C. Banerjee , Horng-Chih Huang , Jinglin J. Li , Raymond E. Miller , David B. Reitz , Samuel J. Tremont
IPC: A61K31/00 , A61K31/38 , A61K31/4035 , A61K31/41 , A61K31/4178 , A61K31/4433 , A61K31/4436 , A61K31/4709 , A61K31/4995 , A61K31/662 , A61K31/67 , A61P1/16 , A61P3/06 , A61P9/10 , A61P43/00 , C07B53/00 , C07C319/14 , C07C323/12 , C07C323/18 , C07C323/19 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/653 , C07F9/6553 , C07K5/06 , C07K5/068 , C08G65/329 , A61K31/44 , C07D211/72 , C07D337/00
CPC classification number: A61K31/38 , C07C319/14 , C07D337/06 , C07D337/08 , C07D409/10 , C07D409/12 , C07D487/08 , C07D495/04 , C07D495/10 , C07F9/65539 , C07K5/06086 , C08G65/329
Abstract: Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.
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10.发明授权Insecticidal and nematocidal heterobicyclic hydroximinates, thiohydroximidates, and carbamate esters, composition, and method of use thereof 失效杀虫和杀线虫异双环肟酸盐，硫代肟酸盐和氨基甲酸酯，组合物及其使用方法
公开(公告)号：US4548929A
公开(公告)日：1985-10-22
申请号：US486211
申请日：1983-04-18
Applicant: Thomas A. Magee , Robert D. Battershell , Lawrence E. Limpel , Andrew W. Ho , Arthur W. Friedman , H. Glenn Corkins , William W. Brand , Russell Buchman , Louis Storace , Edmond R. Osgood
Inventor： Thomas A. Magee , Robert D. Battershell , Lawrence E. Limpel , Andrew W. Ho , Arthur W. Friedman , H. Glenn Corkins , William W. Brand , Russell Buchman , Louis Storace , Edmond R. Osgood
IPC: A01N47/24 , A01N55/00 , A01N57/08 , C07D221/22 , C07D311/00 , C07D313/06 , C07D313/20 , C07D335/04 , C07D335/10 , C07D337/06 , C07D495/08 , C07D495/18 , C07F7/08 , C07F9/24 , C07F9/6561 , A01N43/10 , A01N43/12 , A01N43/18 , A01N43/40 , C07D311/02 , C07D313/08 , C07D407/12 , C07D417/12
CPC classification number: C07D221/22 , A01N47/24 , A01N55/00 , A01N57/08 , C07D311/00 , C07D313/06 , C07D313/20 , C07D335/04 , C07D335/10 , C07D337/06 , C07D495/08 , C07F7/0892 , C07F9/2483 , C07F9/6561
Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. ##STR1##
Abstract translation: 描述了式I的新型杂双环化合物，其制备方法和杀虫组合物和方法。
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