公开(公告)号：US07053059B2

公开(公告)日：2006-05-30

申请号：US10628065

申请日：2003-07-25

申请人： Paul Zieske ,  Leo Martis ,  Carolyn Choo

发明人： Paul Zieske ,  Leo Martis ,  Carolyn Choo

IPC分类号： A61K31/70

CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  A61J1/2027 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61M1/1668 ,  A61M1/28 ,  A61M1/287

摘要： Dialysis solutions with enhanced biocompatibility are provided. The dialysis solutions include a first acidic solution and a second acidic solution that are admixed to form a ready-to-use dialysis solution with reduced levels of glucose degradation products prior to use. The first acidic solution includes a dextrose concentrate, and the second acidic solution includes a buffer concentrate, such as a lactate-based buffer. The first and second acid solutions are separately sterilized prior to mixing to form the ready-to-use dialysis solutions. The dialysis solutions can be used in a variety of different applications, such as infusion into a patient during peritoneal dialysis.

摘要翻译： 提供具有增强的生物相容性的透析溶液。 透析溶液包括第一酸性溶液和第二酸性溶液，其混合以形成使用前葡萄糖降解产物水平降低的即用型透析溶液。 第一酸性溶液包括葡萄糖浓缩物，第二酸性溶液包括缓冲浓缩物，例如基于乳酸盐的缓冲液。 将第一和第二酸溶液在混合之前分开灭菌以形成即用型透析溶液。 透析溶液可用于各种不同的应用，例如在腹膜透析期间输注到患者体内。

公开(公告)号：US20050020507A1

公开(公告)日：2005-01-27

申请号：US10628065

申请日：2003-07-25

申请人： Paul Zieske ,  Leo Martis ,  Carolyn Choo

发明人： Paul Zieske ,  Leo Martis ,  Carolyn Choo

IPC分类号： A61J1/00 ,  A61J1/20 ,  A61K9/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61M1/16 ,  A61M1/28 ,  A61K31/70

CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2024 ,  A61J1/2027 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61M1/1668 ,  A61M1/28 ,  A61M1/287

摘要： Dialysis solutions with enhanced biocompatibility are provided. The dialysis solutions include a first acidic solution and a second acidic solution that are admixed to form a ready-to-use dialysis solution with reduced levels of glucose degradation products prior to use. The first acidic solution includes a dextrose concentrate, and the second acidic solution includes a buffer concentrate, such as a lactate-based buffer. The first and second acid solutions are separately sterilized prior to mixing to form the ready-to-use dialysis solutions. The dialysis solutions can be used in a variety of different applications, such as infusion into a patient during peritoneal dialysis.

摘要翻译： 提供具有增强的生物相容性的透析溶液。 透析溶液包括第一酸性溶液和第二酸性溶液，其混合以形成使用前葡萄糖降解产物水平降低的即用型透析溶液。 第一酸性溶液包括葡萄糖浓缩物，第二酸性溶液包括缓冲浓缩物，例如基于乳酸盐的缓冲液。 将第一和第二酸溶液在混合之前分开灭菌以形成即用型透析溶液。 透析溶液可用于各种不同的应用，例如在腹膜透析期间输注到患者体内。

公开(公告)号：US20060128658A1

公开(公告)日：2006-06-15

申请号：US11351922

申请日：2006-02-10

申请人： Leo Martis ,  Carolyn Choo ,  Paul Zieske

发明人： Leo Martis ,  Carolyn Choo ,  Paul Zieske

IPC分类号： A01N1/02 ,  A61K31/19 ,  A61K31/715

CPC分类号： A61K31/724 ,  A61K31/718 ,  A61M1/287

摘要： Icodextrin-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The icodextrin-based solution at least includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the icodextrin-based solution to be mixed prior to infusion into a patient. The icodextrin-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

摘要翻译： 提供了基于酮糖糊精的溶液及其在药物治疗期间可以使用的制备方法，例如透析治疗。 所述基于糖链糊精的溶液至少包含在约1.5至约5.0的pH范围内含有冰糖糊精的第一溶液和约7.0至约12.0的pH范围的缓冲溶液，所述缓冲溶液被构造和布置，以使得基于粘蛋白的溶液 在输入患者体内混合。 本发明的基于糖链糊精的溶液可以在生理pH和最小的葡萄糖降解产物下进行。

公开(公告)号：US20070293441A1

公开(公告)日：2007-12-20

申请号：US11766471

申请日：2007-06-21

申请人： Carolyn Choo ,  Dirk Faict ,  Alfredo Rodriquez

发明人： Carolyn Choo ,  Dirk Faict ,  Alfredo Rodriquez

IPC分类号： A61K31/70 ,  A61L2/00 ,  A61P43/00

CPC分类号： A61L2/0011 ,  A61L2/0023 ,  A61L2/02 ,  A61L2/04 ,  B65B55/02

摘要： The present disclosure provides a sterilized medical system that includes an ultra high pressure sterilized glucose solution in a container. The sterile glucose solution may contain less than about 40 ppm total glucose degradation product. The glucose solution may be a ready-to-use infusion solution disposed in a single chamber container.

摘要翻译： 本公开提供了一种在容器中包括超高压灭菌葡萄糖溶液的灭菌医疗系统。 无菌葡萄糖溶液可含有小于约40ppm的总葡萄糖降解产物。 葡萄糖溶液可以是设置在单室容器中的即用型输注溶液。