公开(公告)号：US08715340B2

公开(公告)日：2014-05-06

申请号：US11786023

申请日：2007-04-09

申请人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Michael O'Connor

发明人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Michael O'Connor

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/065

摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

摘要翻译： 描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。 一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。 材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。 在一些实施方案中，孔径范围为约10-100μm。 在一些实施方案中，孔等距离地间隔开约40-100μm的孔隙。 孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。 在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。

公开(公告)号：US20090054966A1

公开(公告)日：2009-02-26

申请号：US12279335

申请日：2006-02-13

申请人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Peir Fen Sung

发明人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Peir Fen Sung

IPC分类号： A61F2/06

CPC分类号： C08G18/283 ,  A61F2/07 ,  A61F2250/0023 ,  A61L31/06 ,  C08G18/2885 ,  C08G18/289 ,  C08G18/44 ,  C08L75/04

摘要： An endovascular device (10) for insertion into a bodily vessel (5) to treat a diseased, damaged or weakened portion of a vessel wall (50), the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (20) covering at least a portion of the circumferential surface of said mechanically expandable device (11), the membrane (20) comprising a plurality of pores (25), the porosity of the membrane (20) being defined by the ratio of the material surface area of the membrane (20) determined by the size of the pores (21) and the distance between adjacent pores (22, 23); wherein the mechanically expandable device (10) is positioned in the bodily vessel (5) such that the membrane (20) covers at least the diseased, damaged or weakened portion of the vessel wall (50), the porosity of the membrane (20) obstructing blood supply to the diseased, damaged or weakened portion of the vessel wall (50) and enhancing healing of the bodily vessel (5).

摘要翻译： 一种用于插入身体血管（5）以治疗血管壁（50）的患病，受损或弱化部分的血管内装置（10），所述血管内装置（10）包括：机械可扩张装置（11），其可从 第一位置到第二位置，所述机械可扩张装置（11）径向向外扩展到第二位置，使得所述机械可扩张装置（11）的圆周表面与容器（5）的内表面接合，以便保持 通过所述容器（5）的流体通道; 以及覆盖所述机械可扩张装置（11）的所述圆周表面的至少一部分的膜（20），所述膜（20）包括多个孔（25），所述膜（20）的孔隙度由 通过孔（21）的尺寸和相邻孔（22,23）之间的距离确定的膜（20）的材料表面积的比率; 其中所述机械可扩张装置（10）定位在所述身体容器（5）中，使得所述膜（20）至少覆盖所述血管壁（50）的患病，受损或弱化部分，所述膜（20）的孔隙率 阻止对血管壁（50）的患病，受损或弱化部分的血液供应，并增强身体血管（5）的愈合。