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    Endovascular device with membrane
    1.
    发明授权
    Endovascular device with membrane 有权
    带膜的血管内装置

    公开(公告)号：US08715340B2

    公开(公告)日：2014-05-06

    申请号：US11786023

    申请日：2007-04-09

    申请人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Michael O'Connor

    发明人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Michael O'Connor

    IPC分类号： A61F2/06

    CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/065

    摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

    摘要翻译： 描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。 一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。 材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。 在一些实施方案中，孔径范围为约10-100μm。 在一些实施方案中，孔等距离地间隔开约40-100μm的孔隙。 孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。 在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。

    ENDOVASCULAR DEVICE WITH MEMBRANE
    2.
    发明申请
    ENDOVASCULAR DEVICE WITH MEMBRANE 审中-公开
    具有膜的血管内装置

    公开(公告)号：US20090054966A1

    公开(公告)日：2009-02-26

    申请号：US12279335

    申请日：2006-02-13

    申请人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Peir Fen Sung

    发明人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Peir Fen Sung

    IPC分类号： A61F2/06

    CPC分类号： C08G18/283 ,  A61F2/07 ,  A61F2250/0023 ,  A61L31/06 ,  C08G18/2885 ,  C08G18/289 ,  C08G18/44 ,  C08L75/04

    摘要： An endovascular device (10) for insertion into a bodily vessel (5) to treat a diseased, damaged or weakened portion of a vessel wall (50), the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (20) covering at least a portion of the circumferential surface of said mechanically expandable device (11), the membrane (20) comprising a plurality of pores (25), the porosity of the membrane (20) being defined by the ratio of the material surface area of the membrane (20) determined by the size of the pores (21) and the distance between adjacent pores (22, 23); wherein the mechanically expandable device (10) is positioned in the bodily vessel (5) such that the membrane (20) covers at least the diseased, damaged or weakened portion of the vessel wall (50), the porosity of the membrane (20) obstructing blood supply to the diseased, damaged or weakened portion of the vessel wall (50) and enhancing healing of the bodily vessel (5).

    摘要翻译： 一种用于插入身体血管（5）以治疗血管壁（50）的患病，受损或弱化部分的血管内装置（10），所述血管内装置（10）包括：机械可扩张装置（11），其可从 第一位置到第二位置，所述机械可扩张装置（11）径向向外扩展到第二位置，使得所述机械可扩张装置（11）的圆周表面与容器（5）的内表面接合，以便保持 通过所述容器（5）的流体通道; 以及覆盖所述机械可扩张装置（11）的所述圆周表面的至少一部分的膜（20），所述膜（20）包括多个孔（25），所述膜（20）的孔隙度由 通过孔（21）的尺寸和相邻孔（22,23）之间的距离确定的膜（20）的材料表面积的比率; 其中所述机械可扩张装置（10）定位在所述身体容器（5）中，使得所述膜（20）至少覆盖所述血管壁（50）的患病，受损或弱化部分，所述膜（20）的孔隙率 阻止对血管壁（50）的患病，受损或弱化部分的血液供应，并增强身体血管（5）的愈合。

    Medical Device with Non-Circumferential Surface Portion
    3.
    发明申请
    Medical Device with Non-Circumferential Surface Portion 审中-公开
    具有非圆周表面部分的医疗器械

    公开(公告)号：US20100063531A1

    公开(公告)日：2010-03-11

    申请号：US12093310

    申请日：2005-11-09

    申请人： Leon Rudakov ,  Michael O'Connor ,  Vimal Raj D

    发明人： Leon Rudakov ,  Michael O'Connor ,  Vimal Raj D

    IPC分类号： A61M29/00 ,  A61B5/00

    CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B2017/1205 ,  A61F2/07 ,  A61F2/89 ,  A61F2/958 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2220/0058

    摘要： PCT A medical device (10) for insertion into a bodily vessel (4) to treat an aneurysm (5) having an aneurysm neck, the device (10) comprising: a mechanically expandable device expandable from a first position to a second position; the mechanically expandable device having an exterior circumferential surface at end portions (11, 12) of the mechanically expandable device such that the exterior circumferential surface engages with the inner surface of the vessel (4) so as to maintain a fluid pathway through said vessel (4) when the end portions (11, 12) of the mechanically expandable device are expanded radially outwardly to the second position; the mechanically expandable device having an exterior non-circumferential surface at a connecting portion (13) of the mechanically expandable device to connect the end portions (11, 12); and an expandable membrane (15) extending over a portion of the exterior non-circumferential surface, the membrane (15) is expanded in response to expansion of the mechanically expandable device; wherein the connecting portion (13) is positioned proximal to the aneurysm neck such that the expanded membrane (15) obstructs blood circulation to the aneurysm (5).

    摘要翻译： PCT一种用于插入身体血管（4）以治疗具有动脉瘤颈部的动脉瘤（5）的医疗装置（10），所述装置（10）包括：可从第一位置扩展到第二位置的机械可扩张装置; 所述机械可扩张装置在所述机械可扩张装置的端部部分（11,12）处具有外周表面，使得所述外周表面与所述容器（4）的内表面接合，以便保持通过所述容器的流体路径（ 4）当机械可膨胀装置的端部部分（11,12）径向向外延伸到第二位置时; 所述机械可扩张装置在所述机械可扩张装置的连接部分（13）处具有外部非圆周表面，以连接所述端部部分（11,12）; 以及在所述外部非圆周表面的一部分上延伸的可膨胀膜（15），所述膜（15）响应于所述机械可扩张装置的膨胀而膨胀; 其中所述连接部分（13）位于所述动脉瘤颈部的近侧，使得所述扩张的膜（15）阻止血液循环到所述动脉瘤（5）。

    Endovascular device with membrane
    4.
    发明申请
    Endovascular device with membrane 有权
    带膜的血管内装置

    公开(公告)号：US20070255388A1

    公开(公告)日：2007-11-01

    申请号：US11786023

    申请日：2007-04-09

    申请人： Leon Rudakov ,  Tsui Hong ,  Michael O'Connor

    发明人： Leon Rudakov ,  Tsui Hong ,  Michael O'Connor

    IPC分类号： A61F2/82

    CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/065

    摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

    摘要翻译： 描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。 一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。 材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。 在一些实施方案中，孔径范围为约10-100μm。 在一些实施方案中，孔等距离地间隔开约40-100μm的范围内的孔隙。 孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。 在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。

    Medical device
    5.
    发明授权
    Medical device 有权
    医疗装置

    公开(公告)号：US08500751B2

    公开(公告)日：2013-08-06

    申请号：US11586899

    申请日：2006-10-25

    申请人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    发明人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    IPC分类号： A61F2/06 ,  A61F11/00

    CPC分类号： A61F2/07 ,  A61B17/12118 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/065 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2002/91541 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016

    摘要： A method for treating a bifurcation or trifurcation aneurysm (201) occurring on a first artery, the first artery and a second artery joining to a third artery, the method comprising: inserting a medical device (202) such that it is at least partially located in the first artery and is at least partially located in the third artery; expanding the medical device (202) from a first position to a second position, said medical device (202) is expanded radially outwardly to the second position such that the exterior surface of said medical device (202) engages with the inner surface of the first and third arteries so as to maintain a fluid pathway through said arteries; and positioning the medical device (202) such that a membrane (203) of the medical device (202) is located against an aneurysm neck of the aneurysm (201) to obstruct blood circulation to the aneurysm (201) when the medical device (202) is expanded to the second position, and at least a portion of the membrane (203) is secured to the medical device (202) to maintain the position of the membrane (203) relative to the medical device (202) when expanded to the second position; wherein the membrane (203) is permeable and porous, the size of the pores of the membrane (203) and the ratio of the material surface area of the membrane (203) being such that blood supply to perforators and/or microscopic branches of main brain arteries is permitted to improve healing of the first artery but blood supply to the aneurysm (201) is prevented.

    摘要翻译： 一种用于治疗在第一动脉上发生的分叉或三叉神经动脉瘤（201）的方法，所述第一动脉和连接到第三动脉的第二动脉，所述方法包括：插入医疗装置（202），使得其至少部分位于 在第一动脉中并且至少部分地位于第三动脉中; 将医疗设备（202）从第一位置扩展到第二位置，所述医疗设备（202）径向向外扩展到第二位置，使得所述医疗设备（202）的外表面与第一位置 和第三动脉，以便保持通过所述动脉的流体通道; 以及医疗装置（202）的定位，使得医疗装置（202）的膜（203）抵靠动脉瘤（201）的动脉瘤颈部定位，以在医疗装置（202）处阻止血液循环至动脉瘤 ）扩张到第二位置，并且膜（203）的至少一部分固定到医疗装置（202），以在将膜（203）扩大到第二位置时保持膜（203）相对于医疗装置（202）的位置 第二位 其中所述膜（203）是可渗透和多孔的，所述膜（203）的孔的尺寸和所述膜（203）的材料表面积的比率使得向主要的穿孔器和/或微观分支提供血液供应 允许脑动脉改善第一动脉的愈合，但是防止了对动脉瘤（201）的供血。

    Medical device
    7.
    发明申请
    Medical device 有权
    医疗装置

    公开(公告)号：US20070100430A1

    公开(公告)日：2007-05-03

    申请号：US10580139

    申请日：2004-12-13

    申请人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    发明人： Leon Rudakov ,  Michael O'Connor ,  Deepak Gandhi

    IPC分类号： A61F2/06

    CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/12186 ,  A61F2/07 ,  A61F2/89 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/075 ,  A61F2002/3008 ,  A61F2002/823 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0037 ,  A61F2250/0098

    摘要： A medical device for insertion into a bodily vessel to treat an aneurysm (201), the device comprising: a mechanically expandable device (202) expandable from a first position to a second position, said mechanically expandable device (202) is expanded radially outwardly to the second position such that the exterior surface of said mechanically expandable (202) engages with the inner surface of the vessel so as to maintain a fluid pathway through said vessel; and a membrane (203) expandable from a first position to a second position in response to expansion of said mechanically expandable device (202), said membrane (203) obstructing blood circulation to the aneurysm (201) when expanded to the second position, and at least a portion of the membrane (203) is secured to the mechanically expandable device (202) to maintain the position of the membrane (203) relative to the mechanically expandable device (202) when expanded to the second position.

    摘要翻译： 一种用于插入身体血管以治疗动脉瘤（201）的医疗装置，所述装置包括：可从第一位置扩展到第二位置的机械可扩张装置（202），所述机械可扩张装置（202）径向向外扩张 所述第二位置使得所述机械可膨胀（202）的外表面与所述容器的内表面接合，以便保持通过所述容器的流体通路; 以及响应于所述机械可扩张装置（202）的膨胀而从第一位置扩展到第二位置的膜（203），所述膜（203）在膨胀到第二位置时阻碍血液循环到动脉瘤（201），并且 当膨胀到第二位置时，膜（203）的至少一部分被固定到机械可扩张装置（202）以保持膜（203）相对于机械可扩张装置（202）的位置。