AMINOTETRAHYDROINDAZOLOACETIC ACIDS
    9.
    发明申请
    AMINOTETRAHYDROINDAZOLOACETIC ACIDS 失效
    氨基四氢叶酸

    公开(公告)号:US20120095053A1

    公开(公告)日:2012-04-19

    申请号:US13324650

    申请日:2011-12-13

    CPC分类号: C07D231/56 C07D401/12

    摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

    摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,R 1 -R 3和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。

    AMINOTETRAHYDROINDAZOLOACETIC ACIDS
    10.
    发明申请
    AMINOTETRAHYDROINDAZOLOACETIC ACIDS 失效
    氨基四氢叶酸

    公开(公告)号:US20100016368A1

    公开(公告)日:2010-01-21

    申请号:US12497786

    申请日:2009-07-06

    CPC分类号: C07D231/56 C07D401/12

    摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

    摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,R 1 -R 3和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。