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74 条记录 (耗时 0.044 秒)

    AMINOTETRAHYDROINDAZOLOACETIC ACIDS
    3.
    发明申请
    AMINOTETRAHYDROINDAZOLOACETIC ACIDS 失效
    氨基四氢叶酸

    公开(公告)号：US20120095053A1

    公开(公告)日：2012-04-19

    申请号：US13324650

    申请日：2011-12-13

    申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun

    发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun

    IPC分类号： A61K31/4439 ,  C07D401/12 ,  A61P11/06 ,  C07D405/14

    CPC分类号： C07D231/56 ,  C07D401/12

    摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

    摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，R 1 -R 3和n在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。

    AMINOTETRAHYDROINDAZOLOACETIC ACIDS
    6.
    发明申请
    AMINOTETRAHYDROINDAZOLOACETIC ACIDS 失效
    氨基四氢叶酸

    公开(公告)号：US20100016368A1

    公开(公告)日：2010-01-21

    申请号：US12497786

    申请日：2009-07-06

    申请人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun

    发明人： Li Chen ,  Fariborz Firooznia ,  Paul Gillespie ,  Yun He ,  Tai-An Lin ,  Sung-Sau So ,  HongYing Yun

    IPC分类号： A61K31/416 ,  C07D231/56 ,  C07D401/12 ,  A61K31/4439

    CPC分类号： C07D231/56 ,  C07D401/12

    摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

    摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，R 1 -R 3和n在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。

    Telescoping Shoring Post
    9.
    发明申请
    Telescoping Shoring Post 审中-公开
    伸缩支柱

    公开(公告)号：US20080244996A1

    公开(公告)日：2008-10-09

    申请号：US11661215

    申请日：2005-08-24

    申请人： Paul Gillespie ,  Jonny Melic

    发明人： Paul Gillespie ,  Jonny Melic

    IPC分类号： E04G25/04

    CPC分类号： E04G25/06 ,  E04G25/061 ,  E04G25/065

    摘要： A telescoping post shore having an outer tube; a plurality of slots disposed longitudinally along the outer tube; an inner tube; at least one tongue member affixed to the inner tube and projecting from the inner tube, the at least one tongue member configured to be received by the plurality of slots; wherein the inner tube and at least one tongue member are dimensioned to slide within the outer tube and the inner tube and at least one tongue member can be rotated within the outer tube to engage the at least one tongue member with at least one of the plurality of slots.

    摘要翻译： 具有外管的伸缩柱岸; 沿所述外管纵向设置的多个槽; 内管; 至少一个舌片构件，其固定到所述内管并且从所述内管突出，所述至少一个舌构件被配置为被所述多个狭槽接收; 其中，所述内管和至少一个舌构件的尺寸设计成在所述外管和所述内管内滑动，并且至少一个舌构件可在所述外管内旋转，以使所述至少一个舌构件与所述多个中的至少一个接合 的插槽。