公开(公告)号：US06671428B1

公开(公告)日：2003-12-30

申请号：US09813772

申请日：2001-03-20

申请人： Wei Yang ,  Shu Zhang ,  Li Chen

发明人： Wei Yang ,  Shu Zhang ,  Li Chen

IPC分类号： G02B626

CPC分类号： G02B6/356 ,  G02B6/29311 ,  G02B6/29383 ,  G02B6/3512 ,  G02B6/3556

摘要： An optical cross switch device for selectively switching light beams between a plurality of fiber optic elements. The device includes an input fiber mounting assembly for securing at least one input fiber terminating in a fiber end for radiating an associated input light beam; collimating means for collimating the at least one input light beam; focusing means for focusing light beams incident thereon; an output fiber mounting assembly for securing at least one output fiber terminating in an output fiber end for receiving an associated light beam; and at least one mirror unit having at least one reflective element for selectively redirecting an associated one of the collimated input light beams toward an associated selected one of the output fiber ends via the focusing means.

摘要翻译： 一种用于在多个光纤元件之间选择性地切换光束的光交叉开关装置。 所述装置包括输入光纤安装组件，用于固定终止于光纤端的至少一个输入光纤，用于辐射相关联的输入光束; 用于准直所述至少一个输入光束的准直装置; 用于聚焦入射在其上的光束的聚焦装置; 输出光纤安装组件，用于固定端接在输出光纤端的至少一个输出光纤，用于接收相关联的光束; 以及至少一个具有至少一个反射元件的反射镜单元，用于经由聚焦装置选择性地将相关联的一个准直输入光束重定向到相关联的所选输出光纤端。

公开(公告)号：US06563977B1

公开(公告)日：2003-05-13

申请号：US09605523

申请日：2000-06-27

申请人： Li Chen ,  Shu Zhang ,  Wei Yang

发明人： Li Chen ,  Shu Zhang ,  Wei Yang

IPC分类号： G02B628

CPC分类号： G02B6/29307 ,  G02B6/29308 ,  G02B6/2931 ,  G02B6/29311 ,  G02B6/29397

摘要： An optical multiplexing and demultiplexing device includes: a fiber mounting means for securing a plurality of optical fibers each terminating in a fiber end, at least one of the fiber ends radiating a corresponding input beam having a polarization state defined by a polarization plane that may vary as a function of time, and at least one of the fiber ends for receiving an output beam; collimating and focusing means having a focal length, and providing collimation of the input beams, and focusing of the output beams; diffraction means including at least one diffractive element providing for dispersion of optical beams passing therethrough, each diffractive element having an associated diffraction efficiency that varies as a function of the polarization state of light beams passing therethrough; and a polarization rotating means for rotating the plane of polarization of a beam passing therethrough by a specified number of degrees. The device provides for a particular input beam having a first polarization state to be diffracted by the diffractive elements in accordance with a first diffraction efficiency based on the first polarization state. The beam is then passed through the polarization rotating means at least once and thereby rotated into a second polarization state. The rotated beam is then diffracted by at least one of the diffractive elements in accordance with a second diffraction efficiency based on the second polarization state, whereby the device provides a spectral resolution that is substantially insensitive to variations in the polarization state of the input beam.

摘要翻译： 光复用和解复用装置包括：光纤安装装置，用于固定多个光纤，每个光纤端接在光纤端，所述光纤端中的至少一个辐射具有由可能变化的偏振面定义的偏振状态的对应的输入光束 作为时间的函数，以及用于接收输出光束的光纤端部中的至少一个; 准直和聚焦装置，具有焦距，并提供输入光束的准直和输出光束的聚焦; 衍射装置包括至少一个衍射元件，用于分散通过其中的光束，每个衍射元件具有相关联的衍射效率，该衍射效率随着通过其的光束的偏振状态而变化; 以及偏振旋转装置，用于使通过其的光束的偏振面旋转指定的数量。 该器件根据第一偏振态基于第一衍射效率，提供具有由衍射元件衍射的第一偏振状态的特定输入光束。 光束然后通过偏振旋转装置至少一次，从而旋转到第二偏振状态。 然后，基于第二偏振状态，旋转的光束根据第二衍射效率由至少一个衍射元件衍射，由此该器件提供对输入光束的偏振状态的变化基本上不敏感的光谱分辨率。

公开(公告)号：US06704509B1

公开(公告)日：2004-03-09

申请号：US09715765

申请日：2000-11-17

申请人： Wei Yang ,  Shu Zhang ,  Li Chen

发明人： Wei Yang ,  Shu Zhang ,  Li Chen

IPC分类号： H04B1008

CPC分类号： H04J14/02 ,  H04B10/077 ,  H04B10/07955

摘要： A monitoring system provides for monitoring the optical performance of a plurality of different channels of a fiber optic network, each channel having an associated channel wavelength. The system includes: means for generating a calibration signal including a plurality of stable calibration wavelengths; means for combining a tapped communication signal and the calibration signal to generate a combined signal; and a multi-channel monitoring device. The monitoring device includes: an input optical fiber for receiving the combined signal, and for radiating an input light beam including the communication wavelengths and the calibration wavelengths; a detector unit having an array of pixel detector elements each being responsive to light beams incident thereon, and operative to generate an associated data signal; collimating and focusing means for collimating and focusing beams propagating between the fiber end and the detector unit; and a transmissive grating assembly for diffracting and spatially separating beams propagating between the input fiber end and the detector unit. The grating assembly, collimating and focusing means, and pixel detector elements are configured so that the diffracted beams are spatially separated and focused onto associated ones of the detector elements according to their wavelengths. A data processing unit receives the data signals from the detector unit, and is operative to provide information indicative of the intensities and wavelengths associated with each of the channels of the main communication signal. The processing unit uses the calibration wavelengths as standards to calibrate positional relationships between the spatially diffracted beams and the associated pixel detector elements.

摘要翻译： 监测系统提供用于监测光纤网络的多个不同信道的光学性能，每个信道具有相关联的信道波长。 该系统包括：用于产生包括多个稳定校准波长的校准信号的装置; 用于组合抽头通信信号和校准信号以产生组合信号的装置; 和多通道监控设备。 监视装置包括：输入光纤，用于接收组合信号，并且用于辐射包括通信波长和校准波长的输入光束; 检测器单元，具有像素检测器元件的阵列，每个像素检测器元件响应入射到其上的光束，并且可操作以产生相关联的数据信号; 用于准直和聚焦在光纤端和检测器单元之间传播的光束的准直和聚焦装置; 以及用于衍射和空间分离在输入光纤端和检测器单元之间传播的光束的透射光栅组件。 光栅组件，准直和聚焦装置以及像素检测器元件被配置成使得衍射光束根据其波长在空间上分离并聚焦到相关联的检测器元件上。 数据处理单元从检测器单元接收数据信号，并且可操作以提供指示与主通信信号的每个通道相关联的强度和波长的信息。 处理单元使用校准波长作为标准来校准空间衍射光束和相关联的像素检测器元件之间的位置关系。

公开(公告)号：US6167290A

公开(公告)日：2000-12-26

申请号：US244330

申请日：1999-02-03

申请人： Wei Yang ,  Shu Zhang

发明人： Wei Yang ,  Shu Zhang

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532

摘要： A method and apparatus for non-invasively measuring animal/human blood glucose and other metabolites including an excitation laser source, a negative pressure based sampling port which interfaces to a human or other animal tissue sample in vivo, a Raman spectrometer, and data analysis and display devices. The device can be made in a compact size and may be portable, and it can be used in homes, offices or clinics. A negative atmospheric sampling port is made of a vacuum chamber that is connected with an electrically or manually driven vacuum pump which creates a negative air pressure inside the vacuum chamber. Under the negative air pressure, a substantial amount of blood is "sucked" into a small area of the human finger so that measurement of an enhanced Raman signal can be made.

摘要翻译： 用于非侵入性地测量动物/人血糖和其它代谢物的方法和装置，包括激发激光源，与体内人或其他动物组织样品接口的负压取样口，拉曼光谱仪和数据分析，以及 显示设备。 该装置可以制造成紧凑的尺寸并且可以是便携式的，并且可以在家庭，办公室或诊所中使用。 负大气采样口由真空室制成，该真空室与电动或手动驱动的真空泵连接，该真空泵在真空室内产生负空气压力。 在负空气压力下，大量的血液被“吸入”人的手指的小区域，从而可以测量增强的拉曼信号。

公开(公告)号：US06275630B1

公开(公告)日：2001-08-14

申请号：US09193289

申请日：1998-11-17

申请人： Wei Yang ,  Shu Zhang

发明人： Wei Yang ,  Shu Zhang

IPC分类号： G02B634

CPC分类号： G02B6/29311 ,  G02B6/2938 ,  G02B6/3636 ,  G02B6/3652 ,  G02B6/3672

摘要： An optical multiplexing and demultiplexing device including a fiber mounting assembly for aligning optical fibers, a set of collimating and focusing optics, a transmission grating element, and a mirror element. The fiber mounting assembly alignment element aligns a series substantially close-spaced optical fibers with their ends flush and assembled in a substantially straight line. The optical fibers are either multi-mode or single mode communication fibers capable of transmitting optical wavelengths with substantially high transmittance. The set of collimating and focusing optics, preferably a lens (or mirror) system that contains two (2) or more elements, may be made from optical glasses with uniform refractive indices, optical glasses with gradient indices, plastic optical elements, or diffractive lenses. The transmission grating element can be made from holographic techniques utilizing photosensitive media, where the media having sufficient thickness to provide high diffractive efficiency and wide operation waveband. The photosensitive media providing high spatial resolution in order to generate high groove density—thus high spectral resolution for DWDM applications. The mirror element, having a high reflectance coating for the wavelengths of interest, is arranged at such an angle that the optical radiation will be reflected back to the grating. It will then be diffracted again by the grating then focused to the optical fibers.

摘要翻译： 一种光复用和解复用装置，包括用于对准光纤的光纤安装组件，一组准直和聚焦光学元件，透射光栅元件和反射镜元件。 光纤安装组件对准元件将一系列基本上相距近的光纤对齐，其端部齐平并组装在基本上直线上。 光纤是能够以基本上高的透射率透射光波长的多模或单模通信光纤。 准直和聚焦光学组件，优选地包含两个或更多个元件的透镜（或镜子）系统可以由具有均匀折射率的光学眼镜，具有梯度指数的光学眼镜，塑料光学元件或衍射透镜 。 透射光栅元件可以由利用感光介质的全息技术制成，其中介质具有足够的厚度以提供高的衍射效率和宽的工作波段。 感光介质提供高空间分辨率，以便为DWDM应用产生高沟槽密度，从而达到高分辨率。 具有用于感兴趣的波长的高反射率涂层的镜元件被布置成使得光学辐射将被反射回到光栅的角度。 然后其将被光栅再次衍射，然后聚焦到光纤上。

公开(公告)号：US6108471A

公开(公告)日：2000-08-22

申请号：US362926

申请日：1999-07-27

申请人： Shu Zhang ,  Wei Yang

发明人： Shu Zhang ,  Wei Yang

IPC分类号： G02B6/34 ,  G02B6/36 ,  H04J14/02

CPC分类号： G02B6/2938 ,  G02B6/29308 ,  G02B6/29311 ,  G02B6/3636 ,  G02B6/3652 ,  G02B6/3676

摘要： An optical multiplexing and demultiplexing device includes: a plurality of optical fibers each terminating in a fiber end for radiating and receiving corresponding light beams; a fiber mounting assembly configured to support the optical fibers so that the fiber ends terminate in substantially the same plane, the mounting assembly also being configured to position the fibers in a regular array of N rows and M columns; reflecting means for reflecting beams radiating from the fiber ends; lens means for collimating and focusing beams propagating between the fiber ends and the reflecting means, the lens means having a focal length associated therewith; and diffraction means for diffracting beams propagating between the lens means and the reflecting means. The reflecting means includes a plurality of N reflective elements, each of the N reflective elements being associated with a corresponding one of the N rows. The array is substantially defined by a row axis that is substantially parallel to each of the rows and a column axis that is substantially parallel to each of the columns. Each of the reflective surfaces forms a corresponding first angle of rotation about a first line parallel to the row axis, and a corresponding second angle of rotation about a second line parallel to the column axis. The first angle of rotation of a corresponding one of the reflective surfaces is proportional to a distance measured between the center fiber and the row associated with corresponding reflective surface.

摘要翻译： 光复用和解复用装置包括：多个光纤，每个光纤端接在光纤端，用于辐射和接收对应的光束; 纤维安装组件，被配置为支撑所述光纤，使得所述光纤端部终止于基本上相同的平面中，所述安装组件还构造成将所述光纤定位成N列和M列的规则阵列; 用于反射从光纤端辐射的光束的反射装置; 透镜装置，用于准直和聚焦在光纤端部和反射装置之间传播的光束，透镜装置具有与之相关联的焦距; 以及衍射装置，用于衍射在透镜装置和反射装置之间传播的光束。 反射装置包括多个N个反射元件，N个反射元件中的每一个与N行中相应的一个相关联。 阵列基本上由基本上平行于每行的行轴和基本上平行于每个列的列轴线定义。 每个反射表面围绕平行于行轴线的第一线形成相应的第一旋转角度，并且围绕平行于列轴线的第二线路形成相应的第二旋转角度。 相应的一个反射表面的第一旋转角度与在与对应的反射表面相关联的行的中心光纤之间测得的距离成正比。

公开(公告)号：US09127079B2

公开(公告)日：2015-09-08

申请号：US13501645

申请日：2010-10-15

申请人： Yu Tian Wang ,  Shu Zhang ,  Changiz Taghibiglou

发明人： Yu Tian Wang ,  Shu Zhang ,  Changiz Taghibiglou

IPC分类号： A61K38/10 ,  C07K17/02 ,  C12N15/12 ,  C12N15/63 ,  A61K39/395 ,  C12N5/02 ,  C12N15/85 ,  A61P25/16 ,  A61P25/28 ,  A61P25/00 ,  C07K7/08 ,  C12N5/10 ,  C07K14/47 ,  A61K9/00 ,  A61K47/48 ,  A61K38/00

CPC分类号： A61K38/1709 ,  A61K9/0019 ,  A61K38/00 ,  A61K39/3955 ,  A61K47/645 ,  C07K14/4702

摘要： Described herein are isolated polypeptides having phosphatase and tensin homolog (PTEN) inhibitory activity, vectors and cells for the expression thereof and methods for their use in treating diseases associated with cytotoxic stress, such as spinal cord injury, stroke, traumatic brain injury, multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, and Huntington's disease.

摘要翻译： 本文描述了具有磷酸酶和张力蛋白同源（PTEN）抑制活性的分离的多肽，用于其表达的载体和细胞及其用于治疗与细胞毒性应激相关的疾病如脊髓损伤，中风，创伤性脑损伤，多发性硬化 ，阿尔茨海默病，肌萎缩性侧索硬化（ALS），帕金森病和亨廷顿病。

公开(公告)号：US07595413B2

公开(公告)日：2009-09-29

申请号：US12068662

申请日：2008-02-08

申请人： Jianjun Yi ,  Wenhua Sun ,  Peng Hao ,  Shu Zhang

发明人： Jianjun Yi ,  Wenhua Sun ,  Peng Hao ,  Shu Zhang

IPC分类号： C07F17/00 ,  B01J31/00 ,  C07F7/00 ,  C08F4/44

CPC分类号： C07F17/00 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/02 ,  C08F210/16 ,  C08F2420/03 ,  C08F4/65925 ,  C08F2500/03 ,  C08F210/14

摘要： The invention relates to a phosphine-substituted vinyl containing metallocene catalyst, and also to the preparation process of the same as well as to the application of the catalyst. The catalyst has the general formula of Cp2(CR1═CR2(P(R3)2))MX, wherein Cp is a ligand containing cyclopentadiene having 1˜5 substitutions, of which two neighbors connecting to each other to form fused rings having more than two members; R1-R3 is selected from the groups consisting of hydrogen, C1˜C18 alkyl or perfluoro-alkyl, C6˜C24 aralkyl or alkaryl; M is selected from the groups consisting of metals of the IVB group; and X is selected from the groups consisting of halogens, C1˜C24 alkyl alkoxyl, silicone or alkaryl. With aluminoxane or modified aluminoxane, aluminum alkyl, halogenated aluminum alkyl or their mixture as the catalyst promoter the phosphine-substituted vinyl containing metallocene catalyst may be employed as the major catalyst for the polymerization or copolymerization of alpha-olefin. Due to its high activity, the polymerization may occur at both high and low temperatures with the polymer having higher molecular weight and broader molecular weight distribution.

摘要翻译： 本发明涉及一种膦取代的含乙​​烯基茂金属催化剂，以及其制备方法以及催化剂的应用。 催化剂具有通式Cp2（CR1-CR2（P（R3）2））MX，其中Cp是含有1〜5个取代基的含环戊二烯的配体，其中两个相邻的相互连接形成具有多于 两名成员 R1-R3选自氢，C1〜C18烷基或全氟烷基，C6〜C24芳烷基或烷芳基; M选自IVB族金属组成的组; X选自卤素，C 1 -C 24烷基烷氧基，硅氧烷或烷芳基。 使用铝氧烷或改性的铝氧烷，可以使用烷基铝，卤代烷基铝或它们作为催化剂助催化剂的混合物，其中膦取代的含乙​​烯基的茂金属催化剂可用作α-烯烃聚合或共聚的主要催化剂。 由于其高活性，聚合可以在高温和低温下发生，聚合物具有较高的分子量和较宽的分子量分布。

公开(公告)号：US20080281692A1

公开(公告)日：2008-11-13

申请号：US11747104

申请日：2007-05-10

申请人： Junbo Zhang ,  Tony Ying-Kin Yip ,  Jacky Xugang Wang ,  Jason Zhiqing Hong ,  Shu Zhang

发明人： Junbo Zhang ,  Tony Ying-Kin Yip ,  Jacky Xugang Wang ,  Jason Zhiqing Hong ,  Shu Zhang

IPC分类号： G06Q30/00 ,  G06Q90/00

CPC分类号： G06Q30/02 ,  G06Q20/10 ,  G06Q30/0214 ,  G06Q30/0225 ,  G06Q30/0228 ,  G06Q30/0239

摘要： Systems and methods establish a virtual points clearinghouse. The clearinghouse redeems heterogeneous digital micro-payments-such as bonus points received from various points issuers-across diverse service providers. Points meant for exclusive redemption at one service provider may be directly redeemed for non-corresponding goods of a different service provider. In one implementation, the clearinghouse includes contracts between points issuers, service providers, and a clearinghouse, including intervening conversion rates. A user interface enables a user to manage multiple point balances from a computing device, cell phone, or other mobile device. The user interface enables the user to find diverse goods and to directly obtain the goods by redeeming diverse heterogeneous points. The clearinghouse includes an invoicing engine to enable money flow between users, points issuers, service providers, and the clearinghouse.

摘要翻译： 系统和方法建立虚拟点交换所。 票据交换所兑换异构数字微支付，例如从不同点发行人收到的奖励积分 - 跨不同服务提供商。 在一个服务提供商处用于独家兑换的积分可以直接兑换为不同服务提供商的非对应商品。 在一个实施中，票据交换所包括点发行者，服务提供者和票据交换所之间的合同，包括中介转换率。 用户界面使用户能够管理来自计算设备，蜂窝电话或其他移动设备的多个点余额。 用户界面使用户能够找到不同的商品，并通过赎回不同的异质点来直接获取商品。 票据交换所包括一个发票引擎，用于在用户，点发行者，服务提供商和票据交换中心之间实现货币流动。

公开(公告)号：US20080194854A1

公开(公告)日：2008-08-14

申请号：US12068662

申请日：2008-02-08

申请人： Jianjun Yi ,  Wenhua Sun ,  Peng Hao ,  Shu Zhang

发明人： Jianjun Yi ,  Wenhua Sun ,  Peng Hao ,  Shu Zhang

IPC分类号： C07F7/28 ,  C07F7/00

CPC分类号： C07F17/00 ,  C08F4/65912 ,  C08F10/00 ,  C08F110/02 ,  C08F210/16 ,  C08F2420/03 ,  C08F4/65925 ,  C08F2500/03 ,  C08F210/14

摘要： The invention relates to a phosphine-substituted vinyl containing metallocene catalyst, and also to the preparation process of the same as well as to the application of the catalyst. The catalyst has the general formula of Cp2(CR1═CR2(P(R3)2))MX, wherein Cp is a ligand containing cyclopentadiene having 1˜5 substitutions, of which two neighbors connecting to each other to form fused rings having more than two members; R1-R3 is selected from the groups consisting of hydrogen, C1˜C18 alkyl or perfluoro-alkyl, C6˜C24 aralkyl or alkaryl; M is selected from the groups consisting of metals of the IVB group; and X is selected from the groups consisting of halogens, C1˜C24 alkyl alkoxyl, silicone or alkaryl. With aluminoxane or modified aluminoxane, aluminum alkyl, halogenated aluminum alkyl or their mixture as the catalyst promoter the phosphine-substituted vinyl containing metallocene catalyst may be employed as the major catalyst for the polymerization or copolymerization of alpha-olefin. Due to its high activity, the polymerization may occur at both high and low temperatures with the polymer having higher molecular weight and broader molecular weight distribution.

摘要翻译： 本发明涉及一种膦取代的含乙​​烯基茂金属催化剂，以及其制备方法以及催化剂的应用。 催化剂具有通式Cp 2（CR 1）-CR 2 2（P（R 3）3） 其中Cp是含有1〜5个取代基的含环戊二烯的配体，其中两个相邻的相互连接形成具有多于两个成员的稠环; R 1〜Z 3选自氢，C 1 -C 18烷基或全氟（C 1 -C 18）烷基或全氟 - 烷基，C 6 -C 24芳烷基或烷芳基; M选自IVB族金属组成的组; 并且X选自卤素，C 1 -C 24烷基烷氧基，硅氧烷或烷芳基。 使用铝氧烷或改性的铝氧烷，可以使用烷基铝，卤代烷基铝或它们作为催化剂助催化剂的混合物，其中膦取代的含乙​​烯基的茂金属催化剂可用作α-烯烃聚合或共聚的主要催化剂。 由于其高活性，聚合可以在高温和低温下发生，聚合物具有较高的分子量和较宽的分子量分布。