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    METHODS FOR TREATING STRESS INDUCED EMOTIONAL DISORDERS
    5.
    发明申请
    METHODS FOR TREATING STRESS INDUCED EMOTIONAL DISORDERS 审中-公开
    治疗压力诱发性情绪障碍的方法

    公开(公告)号：US20110009475A1

    公开(公告)日：2011-01-13

    申请号：US12599518

    申请日：2008-07-11

    申请人： Andre Fischer ,  Li-Huei Tsai

    发明人： Andre Fischer ,  Li-Huei Tsai

    IPC分类号： A61K31/365 ,  A61K31/506 ,  A61K31/52 ,  A61K31/7088 ,  A61P25/00

    CPC分类号： A61K31/505 ,  A61K31/13 ,  A61K31/365 ,  A61K31/52 ,  A61K31/7076 ,  A61K31/7088 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to methods and products for treating emotional disorders such as stress induced emotional disorders, as well as related assays and kits. Methods include administering to a subject an effective amount of an agent for targeting the Rac1, Cdk5, p35, PAK-1 pathway to treat the emotional disorder. The agent for targeting the Rac1, Cdk5, p35, PAK-1 pathway may be, for instance a Rac-1 inhibitor, a Cdk5 inhibitor, a PAK-1 activator, or p35 mobilizing agent.

    摘要翻译： 本发明涉及用于治疗情绪障碍如压力诱导的情绪障碍的方法和产品，以及相关的测定和试剂盒。 方法包括向受试者施用有效量的用于靶向Rac1，Cdk5，p35，PAK-1途径以治疗情绪障碍的药剂。 用于靶向Rac1，Cdk5，p35，PAK-1途径的药剂可以是例如Rac-1抑制剂，Cdk5抑制剂，PAK-1激活剂或p35移动剂。

    PRIORITIZED THROTTLING IN A MULTIUSAGE ENVIRONMENT
    8.
    发明申请
    PRIORITIZED THROTTLING IN A MULTIUSAGE ENVIRONMENT 有权
    多重环境中的优先折射

    公开(公告)号：US20150006710A1

    公开(公告)日：2015-01-01

    申请号：US13928236

    申请日：2013-06-26

    申请人： Nikolai Sauerwald ,  David Freidlin ,  Andre Fischer

    发明人： Nikolai Sauerwald ,  David Freidlin ,  Andre Fischer

    IPC分类号： H04L12/24

    CPC分类号： H04L67/322 ,  H04L43/0817 ,  H04L43/0888 ,  H04L43/16 ,  H04L67/125

    摘要： Prioritization criteria can be applied to assign a priority ranking to server processes executed by a backend server, and a utilization of the backend server by server demands can be quantified. Upon determining that the quantified utilization of the backend server has reached or exceeded one or more determined limits on backend utilization, at least a lowest priority server process can be throttled based on one or more throttling parameters.

    摘要翻译： 可以应用优先级标准来为由后端服务器执行的服务器进程分配优先级排序，并且可以对服务器需求的后台服务器的利用进行量化。 在确定后端服务器的量化利用率已经达到或超过一个或多个确定的后端利用率的限制时，可以基于一个或多个限制参数来限制至少最低优先级的服务器进程。

    METHOD FOR PREVENTING OR TREATING MEMORY IMPAIRMENT AND PHARMACEUTICAL COMPOSITIONS USEFUL THEREFORE
    9.
    发明申请
    METHOD FOR PREVENTING OR TREATING MEMORY IMPAIRMENT AND PHARMACEUTICAL COMPOSITIONS USEFUL THEREFORE 审中-公开
    用于预防或治疗记忆障碍和药物组合物的方法

    公开(公告)号：US20130028956A1

    公开(公告)日：2013-01-31

    申请号：US13193841

    申请日：2011-07-29

    申请人： Andre Fischer ,  Athanasios Zovoilis ,  Hope Agbemenyah

    发明人： Andre Fischer ,  Athanasios Zovoilis ,  Hope Agbemenyah

    IPC分类号： A61K31/711 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  C12Q1/68 ,  A61K39/44 ,  A61K9/14 ,  A61K9/127 ,  A61P25/28 ,  A61K31/74 ,  A61K31/713

    CPC分类号： C12N15/113 ,  C12N2310/113 ,  C12N2310/141

    摘要： In a first aspect, the present invention relates to a method for prevention or treating memory impairment and/or a neurodegenerative condition, disorder or disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound targeting a miRNA or any precursor, or targeting the activity of said miRNA or any precursor thereof. In particular, the present invention relates to a method wherein the targeted miRNA is miR-34. Moreover, the present invention relates to a method for improving memory functionality in a subject suffering from memory loss, said method comprises the reduction or reducing the level of miR-34 levels or precursor molecule levels in brain tissue of said subject administering to the subject a therapeutically effective amount of a compound targeting miR-34 or any precursor thereof.Moreover, the present invention relates to a method of inducing memory loss in an individual comprising administering to said individual an effective amount of one or more compounds having the functionality of miR-34, in particular of miR-34c or any precursor thereof. In addition, a method for diagnosing or predicting memory impairment and/or neurodegenerative condition, disorder or disease is provided. Finally, the present invention relates to a pharmaceutical composition containing a compound targeting miR-34 or precursor molecules thereof.

    摘要翻译： 在第一方面，本发明涉及在有需要的受试者中预防或治疗记忆障碍和/或神经变性病症，病症或疾病的方法，包括向所述受试者施用治疗有效量的靶向miRNA的化合物 或任何前体，或靶向所述miRNA或其任何前体的活性。 特别地，本发明涉及其中靶向miRNA是miR-34的方法。 此外，本发明涉及一种用于改善患有记忆丧失的受试者的记忆功能的方法，所述方法包括降低或降低所述受试者的脑组织中miR-34水平或前体分子水平的水平， 治疗有效量的靶向miR-34或其任何前体的化合物。 此外，本发明涉及一种诱导个体记忆丧失的方法，包括向所述个体施用有效量的一种或多种具有miR-34，特别是miR-34c或其任何前体的功能的化合物。 此外，提供了用于诊断或预测记忆障碍和/或神经变性病症，障碍或疾病的方法。 最后，本发明涉及含有靶向miR-34或其前体分子的化合物的药物组合物。