-
1.发明申请EPIGENETIC MECHANISMS RE-ESTABLISH ACCESS TO LONG-TERM MEMORY AFTER NEURONAL LOSS 审中-公开神经机制在神经损失后重新获得长期记忆公开(公告)号：US20120039909A1
公开(公告)日：2012-02-16
申请号：US13279636
申请日：2011-10-24
IPC分类号： A61K31/167 , A61K31/404 , A61K31/166 , A61K31/353 , A61K48/00 , A61P25/00 , A61K39/395 , A61K31/7068 , A61K31/19 , A61K31/4406 , A61P25/28 , A61K31/4192 , A61K31/7088
CPC分类号： A61K31/164 , A61K31/19 , A61K31/215 , A61K31/404 , A61K31/4192 , A61K31/7052 , A61K31/7068
摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
摘要翻译： 本发明涉及用于增强和改善丢失记忆恢复的方法和产品。 特别是通过增加组蛋白乙酰化来实现这些方法。
-
2.发明授权Epigenetic mechanisms re-establish access to long-term memory after neuronal loss 有权神经元损失后，表观遗传学机制重新获得长期记忆公开(公告)号：US08088951B2
公开(公告)日：2012-01-03
申请号：US11998834
申请日：2007-11-30
IPC分类号： C07C233/00
CPC分类号： A61K31/164 , A61K31/19 , A61K31/215 , A61K31/404 , A61K31/4192 , A61K31/7052 , A61K31/7068
摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
摘要翻译： 本发明涉及用于增强和改善丢失记忆恢复的方法和产品。 特别是通过增加组蛋白乙酰化来实现这些方法。
-
3.发明申请Epigenetic mechanisms re-establish access to long-term memory after neuronal loss 有权神经元损失后，表观遗传学机制重新获得长期记忆公开(公告)号：US20080300205A1
公开(公告)日：2008-12-04
申请号：US11998834
申请日：2007-11-30
申请人： Li-Huei Tsai , Andre Fischer , Stephen Haggarty , Weiping Tang
发明人： Li-Huei Tsai , Andre Fischer , Stephen Haggarty , Weiping Tang
IPC分类号： A61K31/7052 , A61K31/19 , A61K31/215 , A61K31/164 , A61P25/00 , A61K31/4192 , A61K31/404 , A61K31/7068
CPC分类号： A61K31/164 , A61K31/19 , A61K31/215 , A61K31/404 , A61K31/4192 , A61K31/7052 , A61K31/7068
摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
摘要翻译： 本发明涉及用于增强和改善丢失记忆恢复的方法和产品。 特别是通过增加组蛋白乙酰化来实现这些方法。
-
公开(公告)号：US20120101147A1
公开(公告)日：2012-04-26
申请号：US13132179
申请日：2009-12-02
申请人： Li-Huei Tsai , Andre Fischer , Stephen J. Haggarty , Weiping Tang , Stuart L. Schreiber , Edward Holson , Florence Wagner , Mikel P. Moyer
发明人： Li-Huei Tsai , Andre Fischer , Stephen J. Haggarty , Weiping Tang , Stuart L. Schreiber , Edward Holson , Florence Wagner , Mikel P. Moyer
IPC分类号： A61K31/7088 , A61K31/496 , A61K31/4436 , A61P25/28 , A61K31/381 , A61K31/18 , A61K31/16 , A61K31/165 , A61P25/00 , A61K31/44
CPC分类号： A61K31/00 , A61K9/0085 , A61K31/167 , A61K31/353 , A61K31/381 , A61K31/4418 , A61K31/4436 , A61K31/496 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDAC1/2 or HDAC1/2/3.
摘要翻译： 本发明涉及用于增强和改善丢失记忆恢复的方法和产品。 特别地，所述方法通过抑制HDAC2和/或选择性抑制HDAC1 / 2或HDAC1 / 2/3来实现。
-
公开(公告)号：US20100015130A1
公开(公告)日：2010-01-21
申请号：US12474229
申请日：2009-05-28
申请人： Li-Huei Tsai , Yingwei Mao , Jon Madison , Stephen Haggarty
发明人： Li-Huei Tsai , Yingwei Mao , Jon Madison , Stephen Haggarty
IPC分类号： A61K39/395 , A61K38/00 , A61K31/496 , A61K31/445 , C07D409/14 , C07D211/08 , C07D207/14 , C07D405/14 , A61P29/00 , A61P37/00 , A61P25/00
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/351 , A61K31/40
摘要： The invention relates to methods of treating neurological disorders in a subject, by activating a DISC1 pathway. Methods of promoting neurogenesis in adult neural progenitor cells, enhancing nerve generation and treating GSK3 disorders as well as related compositions are also provided.
摘要翻译： 本发明涉及通过激活DISC1途径治疗受试者神经障碍的方法。 还提供了促进成年神经祖细胞神经发生，增强神经产生和治疗GSK3疾病以及相关组合物的方法。
-
公开(公告)号：US20130004517A1
公开(公告)日：2013-01-03
申请号：US13608166
申请日：2012-09-10
申请人： Li-Huei Tsai , Yingwei Mao , Jon Madison , Stephen Haggarty
发明人： Li-Huei Tsai , Yingwei Mao , Jon Madison , Stephen Haggarty
IPC分类号： A61K39/395 , A61K31/40 , A61K31/445 , A61K31/496 , A61K31/7056 , C12N5/079 , A61P25/28 , A61P25/18 , A61P25/24 , A61P25/30 , A61P25/16 , A61K31/5383 , A61P25/00
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/351 , A61K31/40
摘要： The invention relates to methods of treating neurological disorders in a subject, by activating a DISC1 pathway. Methods of promoting neurogenesis in adult neural progenitor cells, enhancing nerve generation and treating GSK3 disorders as well as related compositions are also provided.
摘要翻译： 本发明涉及通过激活DISC1途径治疗受试者神经障碍的方法。 还提供了促进成年神经祖细胞神经发生，增强神经产生和治疗GSK3疾病以及相关组合物的方法。
-
公开(公告)号：US09241916B2
公开(公告)日：2016-01-26
申请号：US11955680
申请日：2007-12-13
申请人： David A. Sinclair , Li-Huei Tsai , Andre Fischer
发明人： David A. Sinclair , Li-Huei Tsai , Andre Fischer
IPC分类号： A01N37/18 , A61K38/00 , C07H21/04 , A61K31/122 , A61K31/015 , A61K31/05 , A61K31/352 , A61K31/415 , A61K31/473 , A61K31/519
CPC分类号： A61K31/122 , A61K31/015 , A61K31/05 , A61K31/352 , A61K31/415 , A61K31/473 , A61K31/519 , G01N2333/98 , G01N2800/2814
摘要： Provided herein are methods and compositions for enhancing the cognitive performance of a subject in need thereof. A method may include administering to a subject an agent that increases the level of protein or activity of a sirtuin, such as SIRT1.
摘要翻译： 本文提供用于增强有需要的受试者的认知表现的方法和组合物。 方法可以包括向受试者施用增加沉默调节蛋白（例如SIRT1）的蛋白质或活性水平的试剂。
-
公开(公告)号：US20110009475A1
公开(公告)日：2011-01-13
申请号：US12599518
申请日：2008-07-11
申请人： Andre Fischer , Li-Huei Tsai
发明人： Andre Fischer , Li-Huei Tsai
IPC分类号： A61K31/365 , A61K31/506 , A61K31/52 , A61K31/7088 , A61P25/00
CPC分类号： A61K31/505 , A61K31/13 , A61K31/365 , A61K31/52 , A61K31/7076 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： The invention relates to methods and products for treating emotional disorders such as stress induced emotional disorders, as well as related assays and kits. Methods include administering to a subject an effective amount of an agent for targeting the Rac1, Cdk5, p35, PAK-1 pathway to treat the emotional disorder. The agent for targeting the Rac1, Cdk5, p35, PAK-1 pathway may be, for instance a Rac-1 inhibitor, a Cdk5 inhibitor, a PAK-1 activator, or p35 mobilizing agent.
摘要翻译： 本发明涉及用于治疗情绪障碍如压力诱导的情绪障碍的方法和产品，以及相关的测定和试剂盒。 方法包括向受试者施用有效量的用于靶向Rac1，Cdk5，p35，PAK-1途径以治疗情绪障碍的药剂。 用于靶向Rac1，Cdk5，p35，PAK-1途径的药剂可以是例如Rac-1抑制剂，Cdk5抑制剂，PAK-1激活剂或p35移动剂。
-
9.发明授权Use of CI-994 and dinaline for the treatment of memory/cognition and anxiety disorders 有权使用CI-994和迪拉尼碱治疗记忆/认知和焦虑症公开(公告)号：US08841346B2
公开(公告)日：2014-09-23
申请号：US13595048
申请日：2012-08-27
申请人： Li-Huei Tsai , Ji-Song Guan , Stephen J. Haggarty , Edward Holson , Florence Wagner , Johannes Graeff
发明人： Li-Huei Tsai , Ji-Song Guan , Stephen J. Haggarty , Edward Holson , Florence Wagner , Johannes Graeff
IPC分类号： A01N37/18 , A61K31/16 , A61K31/165 , A61K31/195 , C07C237/42 , A61K45/06 , A61K31/167
CPC分类号： A61K31/195 , A61K31/167 , A61K45/06 , C07C237/42 , A61K2300/00
摘要： The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
摘要翻译： 本发明涉及用于促进认知功能和/或治疗认知功能障碍和损伤的方法和组合物。 特别地，所述方法通过给予受试者CI-994或迪拉丁胺或其药学上可接受的盐，酯，前药或代谢物来完成。
-
10.发明申请USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS 有权CI-994和DINALINE用于治疗记忆/认知和恶心疾病的使用公开(公告)号：US20110224303A1
公开(公告)日：2011-09-15
申请号：US12917402
申请日：2010-11-01
申请人： Li-Huei Tsai , Ji-Song Guan , Stephen J. Haggarty , Edward Holson , Florence Wagner , Johannes Graeff
发明人： Li-Huei Tsai , Ji-Song Guan , Stephen J. Haggarty , Edward Holson , Florence Wagner , Johannes Graeff
IPC分类号： A61K31/167 , C07C237/40 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/30
CPC分类号： A61K31/195 , A61K31/167 , A61K45/06 , C07C237/42 , A61K2300/00
摘要： The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
摘要翻译： 本发明涉及用于促进认知功能和/或治疗认知功能障碍和损伤的方法和组合物。 特别地，所述方法通过给予受试者CI-994或迪拉丁胺或其药学上可接受的盐，酯，前药或代谢物来完成。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.026 秒)
