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    ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF
    1.
    发明申请
    ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF 有权
    第一类组蛋白活化剂（HDACS）的激活剂及其用途

    公开(公告)号：US20130096129A1

    公开(公告)日：2013-04-18

    申请号：US13554670

    申请日：2012-07-20

    申请人： Li-Huei Tsai ,  Ling Pan ,  Stephen J. Haggarty ,  Debasis Patnaik

    发明人： Li-Huei Tsai ,  Ling Pan ,  Stephen J. Haggarty ,  Debasis Patnaik

    IPC分类号： C07C219/28 ,  C07D487/04 ,  C07D405/12 ,  C07D307/52 ,  C07D409/12

    CPC分类号： C07D405/12 ,  C07C217/58 ,  C07C219/28 ,  C07D307/40 ,  C07D307/52 ,  C07D409/12 ,  C07D411/12 ,  C07D487/04

    摘要： The present invention provides compounds of Formulae (A), (B), (C), and (D), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and kits thereof. The present invention further provides methods of using the compounds to treat or prevent neurological disorders. In one aspect, the methods include administering to a subject in need of treatment for a neurological disorder a therapeutically effective amount of DAC-001, DAC-002, DAC-003, DAC-009, or DAC-012, or a compound of Formula (A), (B), (C), or (D).

    摘要翻译： 本发明提供式（A），（B），（C）和（D）的药学上可接受的盐，溶剂合物，水合物，多晶型物，共晶体，互变异构体，立体异构体，同位素标记的衍生物及其前药的化合物， 其药物组合物及其试剂盒。 本发明还提供使用该化合物治疗或预防神经障碍的方法。 在一个方面，所述方法包括向需要治疗神经障碍的受试者施用治疗有效量的DAC-001，DAC-002，DAC-003，DAC-009或DAC-012或式 （A），（B），（C）或（D）。

    In-vitro system of micropropagation of rose scented pelargonium graveolens, of bourbon type
    3.
    发明授权
    In-vitro system of micropropagation of rose scented pelargonium graveolens, of bourbon type 失效
    波旁型玫瑰香气天竺葵的微繁体外体系

    公开(公告)号：US07470832B2

    公开(公告)日：2008-12-30

    申请号：US10453016

    申请日：2003-06-03

    申请人： Anil Kush Kumar ,  Debasis Patnaik

    发明人： Anil Kush Kumar ,  Debasis Patnaik

    IPC分类号： A01N63/00 ,  A01H3/00

    CPC分类号： A01H4/005 ,  A01H5/02 ,  A01H6/42

    摘要： A highly efficient in-vitro system of micropropagation of rose scented Geranium, Pelargonium graveolens L. Herit by a direct regeneration method to produce a large number of viable true to the type plants maintaining the genotype of an elite mother plant is provided. The process involves inoculating nodal explants on shoot regeneration and multiplication medium, transferring the multiple shots for further growth on medium for shoot growth, further transferring the shoot with sufficient growth to medium for rooting. The present invention also provides a process for the primary and secondary hardening of the in vitro generated plants with the efficient root regeneration system, which is hardened to give about 95% survival in the field conditions. The multiplication ratio achieved by the process is of the order of 1:12-1:20, resulting in significantly low cost of production in relatively lesser time.

    摘要翻译： 提供了一种高效的体外微生殖玫瑰香草天竺葵，天竺葵grave ens it it it it it it it it it it by。。。。。。。。。。。。。。。。。。。。。。。。。。。 该方法包括在芽再生和繁殖培养基上接种淋巴结外植体，转移多次照射以在培养基上进一步生长用于枝条生长，进一步将具有足够生长的芽转移至培养基用于生根。 本发明还提供了一种使用有效的根再生系统对体外产生的植物进行一次和二次硬化的方法，其被硬化以在现场条件下提供约95％的存活。 该方法实现的倍增比为1：12-1：20，导致生产成本相对较低的时间显着降低。

    In-vitro system of micropropagation of rose scented pelargonium graveolens, of bourbon type
    6.
    发明申请
    In-vitro system of micropropagation of rose scented pelargonium graveolens, of bourbon type 失效
    波旁型玫瑰香气天竺葵的微繁体外体系

    公开(公告)号：US20050076413A1

    公开(公告)日：2005-04-07

    申请号：US10453016

    申请日：2003-06-03

    申请人： Anil Kumar ,  Debasis Patnaik

    发明人： Anil Kumar ,  Debasis Patnaik

    IPC分类号： A01H3/00 ,  A01H4/00 ,  A01H5/02 ,  A01N63/00

    CPC分类号： A01H4/005 ,  A01H5/02 ,  A01H6/42

    摘要： A highly efficient in-vitro system of micropropagation of rose scented Geranium, Pelargonium graveolens L. Herit by a direct regeneration method to produce a large number of viable true to the type plants maintaining the genotype of an elite mother plant is provided. The process involves inoculating nodal explants on shoot regeneration and multiplication medium, transferring the multiple shots for further growth on medium for shoot growth, further transferring the shoot with sufficient growth to medium for rooting. The present invention also provides a process for the primary and secondary hardening of the in vitro generated plants with the efficient root regeneration system, which is hardened to give about 95% survival in the field conditions. The multiplication ratio achieved by the process is of the order of 1:12 -1:20, resulting in significantly low cost of production in relatively lesser time

    摘要翻译： 提供了一种高效的体外微生殖玫瑰香草天竺葵，天竺葵grave ens it it it it it it it it it it by。。。。。。。。。。。。。。。。。。。。。。。。。。。 该方法包括在芽再生和繁殖培养基上接种淋巴结外植体，转移多次照射以在培养基上进一步生长用于枝条生长，进一步将具有足够生长的芽转移至培养基用于生根。 本发明还提供了一种使用有效的根再生系统对体外产生的植物进行一次和二次硬化的方法，其被硬化以在现场条件下提供约95％的存活。 该方法实现的倍增比为1:12 -1：20，导致生产成本相对较低的时间显着降低

    Development of a highly efficient in vitro system of micropropagation of solanum viarum
    7.
    发明授权
    Development of a highly efficient in vitro system of micropropagation of solanum viarum 失效
    开发了一种高效的体外微孢子虫繁殖体系

    公开(公告)号：US07445932B2

    公开(公告)日：2008-11-04

    申请号：US10452989

    申请日：2003-06-03

    申请人： Anil Kush Kumar ,  Debasis Patnaik

    发明人： Anil Kush Kumar ,  Debasis Patnaik

    IPC分类号： C12N5/00 ,  C12N5/02

    CPC分类号： A01H4/005

    摘要： Solanum viarum is an alkaloid producing plant of the family Solanaceae with varied therapeutic uses. In order to grow the plant in large areas; one needs to have an efficient system of vegetative multiplication, which ensures its genetic uniformity, and true to the type nature. In nature largely seeds propagate plant, which could be result of cross-pollination which may result in genetic drift. The present invention provides an efficient micropropagation system, with high level of multiplication at relatively low cost of production. The multiplication ratio was as high as 1:6 and almost 95% the plants were viable and successfully cultivated in field. The present invention provides an ideal way of mass cultivation of the selected elite plant material.

    摘要翻译： Solanum viarum是一种具有不同治疗用途的茄科的生物碱生产植物。 为了在大面积种植植物; 人们需要有一个有效的营养繁殖体系，确保其遗传均匀性，并符合类型性质。 在本质上，大部分种子繁殖植物，这可能是异花授粉的结果，这可能导致遗传漂移。 本发明提供了一种高效的微繁殖系统，其生产成本较低，具有高水平的繁殖。 繁殖率高达1：6，几乎95％的植物在田间成活，成功栽培。 本发明提供了选择的精英植物材料的理想的大规模种植方式。