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公开(公告)号：US07338663B2
公开(公告)日：2008-03-04
申请号：US10609061
申请日：2003-06-28
IPC分类号： A61K9/00
CPC分类号： A61K9/0004 , A61K31/085
摘要： The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.
摘要翻译： 本发明包括可膨胀渗透层和用于提供可膨胀渗透层的涂层悬浮液，两者都可用于制造控释剂型。 本发明的可膨胀渗透层可以使用本发明的涂布悬浮液来制造。 有利地，本发明的涂层悬浮液可用于在湿法和干法处理条件下涂覆可膨胀渗透层，而不会牺牲所生产的可膨胀渗透层的质量，因此提供了有利于商业生产受控释放的相对坚固的涂层悬浮液 剂型，包括涂覆的可扩张渗透层。
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公开(公告)号：US06719751B2
公开(公告)日：2004-04-13
申请号：US10281025
申请日：2002-10-24
申请人： Liang-Chang Dong , Patrick S.-L. Wong , Atul Devdatt Ayer , Padmaja Shivanand , Michael A. DesJardin
发明人： Liang-Chang Dong , Patrick S.-L. Wong , Atul Devdatt Ayer , Padmaja Shivanand , Michael A. DesJardin
IPC分类号： A61K926
CPC分类号： A61K9/0004
摘要： A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.
摘要翻译： 公开了由挤出聚合物管制成的剂型以及用于制造剂型的方法。 剂型优选为渗透剂型，并且包括治疗剂和包含在挤出的聚合物管的内腔内的可发性组合物。
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公开(公告)号：US06491683B1
公开(公告)日：2002-12-10
申请号：US09656495
申请日：2000-09-07
申请人： Liang-Chang Dong , Patrick S. L. Wong , Atul Devdatt Ayer , Padmaja Shivanand , Michael A. DesJardin
发明人： Liang-Chang Dong , Patrick S. L. Wong , Atul Devdatt Ayer , Padmaja Shivanand , Michael A. DesJardin
IPC分类号： A61K926
CPC分类号： A61K9/0004
摘要： A dosage form manufactured from an extruded polymer tube and method for manufacturing the dosage form are disclosed. The dosage form is preferably an osmotic dosage form and includes a therapeutic agent and an expandable composition contained within the lumen of the extruded polymer tube.
摘要翻译： 公开了由挤出聚合物管制成的剂型以及用于制造剂型的方法。 剂型优选为渗透剂型，并且包括治疗剂和包含在挤出的聚合物管的内腔内的可发性组合物。
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公开(公告)号：US20050175697A1
公开(公告)日：2005-08-11
申请号：US11024378
申请日：2004-12-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
发明人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
CPC分类号： A61K9/0004 , A61K9/209 , A61K31/35
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
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公开(公告)号：US20050175690A1
公开(公告)日：2005-08-11
申请号：US11024330
申请日：2004-12-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
发明人： David Edgren , Frank Jao , Rhea Kimbel , Shaoling Li , Noymi Yam , Sylvia Seroff , Padmaja Shivanand
CPC分类号： A61K9/209 , A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
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公开(公告)号：US20070243254A1
公开(公告)日：2007-10-18
申请号：US11737829
申请日：2007-06-28
申请人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
发明人： David Edgren , Frank Jao , Rhea Kimbel , Padmaja Shivanand , Atul Ayer , Gurdish Bhatti , Andrew Lam , Shu Li , Robert Skluzacek , Winnie To , Patrick Wong , Shaoling Li , Noymi Yam , Sylvia Serofff
CPC分类号： A61K9/0004
摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.
摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。
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7.发明申请Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation 审中-公开通过增强的分散配方，长时间均匀地输送托吡酯公开(公告)号：US20050058707A1
公开(公告)日：2005-03-17
申请号：US10910040
申请日：2004-08-03
申请人： Iran Reyes , Noymi Yam , Padmaja Shivanand , Shaoling Li , Patrick Wong
发明人： Iran Reyes , Noymi Yam , Padmaja Shivanand , Shaoling Li , Patrick Wong
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K9/4866 , A61K31/35
摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form delivered as a dry or substantially dry erodible solid at a uniform rate over a prolonged period of time are described.
摘要翻译： 描述了用于增强托吡酯在控制释放剂型中的分散性的组合物和剂型，其作为干燥或基本上干燥的可侵蚀固体以均匀速率在延长的时间段内递送。
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公开(公告)号：US20050136108A1
公开(公告)日：2005-06-23
申请号：US10920934
申请日：2004-08-18
申请人： Noymi Yam , Padmaja Shivanand , Rhea Kimbel , Clark Allphin , Patrick Wong
发明人： Noymi Yam , Padmaja Shivanand , Rhea Kimbel , Clark Allphin , Patrick Wong
CPC分类号： A61K9/0004
摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form released from the dosage form as a dry or substantially dry erodible solid over a prolonged period of time at a stepwise increasing rate of release are described.
摘要翻译： 描述了以逐步增加的释放速率在长时间内作为干燥或基本上干燥的可侵蚀固体从剂型释放的控释剂型中的托吡酯增强分散的组合物和剂型。
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公开(公告)号：US06346270B1
公开(公告)日：2002-02-12
申请号：US09587686
申请日：2000-06-05
IPC分类号： A61K924
CPC分类号： A61K9/0004 , A61K31/4166
摘要： A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.
摘要翻译： 公开了治疗组合物，剂型和方法，用于施用用于治疗癫痫的苯妥英。
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公开(公告)号：US20050238709A1
公开(公告)日：2005-10-27
申请号：US10639914
申请日：2003-08-12
申请人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
发明人： Andrew Lam , Padmaja Shivanand , Atul Ayer , Zahedeh Hatamkhany , Suneel Gupta , Diane Guinta , Carol Christopher , Samuel Saks , Lawrence Hamel , Jeri Wright , Richard Weyers
IPC分类号： A61K9/00 , A61K9/20 , A61K9/24 , A61K9/50 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458 , A61K31/445
CPC分类号： A61K9/2086 , A61K9/0002 , A61K9/0004 , A61K9/2072 , A61K9/209 , A61K9/5084 , A61K9/70 , A61K31/00 , A61K31/137 , A61K31/421 , A61K31/4422 , A61K31/4458
摘要： Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal tract at an ascending release rate over an extended time period are provided. The dosage forms may additionally comprise an immediate-release dose of drug.
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