公开(公告)号：US20250044225A1

公开(公告)日：2025-02-06

申请号：US18793185

申请日：2024-08-02

Applicant: Life Technologies Corporation

Inventor： Daniel Quigley ,  Daniel Nelson Fox ,  Keith Johnson

IPC: G01N21/53 ,  G01N1/20 ,  G01N21/05

Abstract: A detection system that operates with reduced sample waste and dead volume, the system including: a module configured to introduce a sample spacer into a sample; at least one light source, wherein the light source illuminates the sample spacer and the sample, wherein illumination of the sample spacer produces scattered light; and a detection device configured to initiate acquisition of data related to the sample in response to scattered light detected by the detection device.

公开(公告)号：US20250003859A1

公开(公告)日：2025-01-02

申请号：US18756372

申请日：2024-06-27

Applicant: Life Technologies Corporation

Inventor： Samuel Henry Adler Rudy ,  Daniel Nelson Fox ,  Nicholas John Rohrbacker

IPC: G01N15/1429 ,  G01N15/01 ,  G01N15/10 ,  G01N15/149

Abstract: Disclosed herein are apparatuses, systems, as well as related methods, computing devices, and computer-readable media related to real time cell sorter cell sorting using embeddings. For example, in some embodiments a method may comprise receiving first cell sorter data. The first cell sorter data may include cell sorter data including microscopy data, hyperspectral imaging data, high-dimensional vector data, or one or more combinations thereof. In some embodiments, the cell sorter data may include quantitative fluorescence data expressed as one or more of antibodies bound per cell, antibody binding capacity (ABC), molecules of equivalent soluble fluorochrome (MESF), one or more other quantitative indicators of fluorescence, or one or more combinations thereof. In some embodiments, the quantitative fluorescence data includes one or more fluorescence signals from: one or more fluorescent proteins, one or more fluorescent dyes, one or more fluorescently conjugate antibodies, or one or more combinations thereof.