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公开(公告)号：US6087326A
公开(公告)日：2000-07-11
申请号：US007604
申请日：1998-01-15
IPC分类号： G01N33/53 , A61K38/00 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/71 , C07K14/715 , C12N15/00 , C12N15/09 , C12Q1/02 , G01N33/566 , A61K38/02 , A61K38/17 , C07K2/00 , C07K14/435
CPC分类号： C07K14/71 , C07K14/475 , A61K38/00
摘要： Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.
摘要翻译： 用于鉴定可用于诊断或治疗神经疾病或损伤的药理学试剂的铅化合物的组合物包括包含分离的网状蛋白和分离的天然netrin受体的混合物，例如“在结肠直肠癌中被删除”（DCC）和新生素。 一般方法包括孵育分离的哺乳动物netrin，分离的天然哺乳动物netrin受体和候选药理学试剂的混合物，并确定试剂的存在是否调节netrin与受体的结合。
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公开(公告)号：US5747262A
公开(公告)日：1998-05-05
申请号：US551874
申请日：1995-10-16
IPC分类号： G01N33/53 , A61K38/00 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/71 , C07K14/715 , C12N15/00 , C12N15/09 , C12Q1/02 , G01N33/566
CPC分类号： C07K14/71 , C07K14/475 , A61K38/00
摘要： Compositions for identifying lead compounds for pharmacological agents useful in the diagnosis or treatment of neurological disease or injury include mixtures comprising an isolated netrin and an isolated natural netrin receptor such as "Deleted in Colorectal Carcinoma" (DCC) and neogenin. The general methods involve incubating a mixture of an isolated mammalian netrin, an isolated natural mammalian netrin receptor, and a candidate pharmacological agent, and determining if the presence of the agent modulates the binding of the netrin to the receptor.
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