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公开(公告)号：US10195340B2
公开(公告)日：2019-02-05
申请号：US13516547
申请日：2009-12-16
申请人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
发明人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
摘要： A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).
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公开(公告)号：US09833562B2
公开(公告)日：2017-12-05
申请号：US13516169
申请日：2009-12-16
申请人： Ralph Sonderegger , Curt Bingham , Lionel Vedrine
发明人： Ralph Sonderegger , Curt Bingham , Lionel Vedrine
CPC分类号： A61M5/14244 , A61M5/14586 , A61M5/2033 , A61M2005/14506 , A61M2005/1585
摘要： A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.
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公开(公告)号：US20120310175A1
公开(公告)日：2012-12-06
申请号：US13516547
申请日：2009-12-16
申请人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
发明人： Lionel Vedrine , Ralph Sonderegger , Curt Bingham
CPC分类号： A61M5/1452 , A61M5/14248 , A61M2005/14252
摘要： A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including a main body having a top enclosure (116) and a bottom enclosure (104), a reservoir (160) disposed within the main body for containing the medicament, and an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and selectively communicating with the reservoir (160). The device also includes a pressurizing system (600, 140) for selectively pressurizing the reservoir (160). In a pre-activated position, the pressurizing system (600, 140) contacts and compresses the reservoir (160) to reduce the initial volume of the reservoir (160), thereby allowing for partial filling of the reservoir (160).
摘要翻译： 一种用于通过注入或穿过患者皮肤将药物输送到患者体内的装置（100），包括具有顶部外壳（116）和底部外壳（104）的主体，设置在主体内的储存器（160） 用于容纳药物的主体和用于穿透患者皮肤的注射针（152），所述针（152）具有内腔并选择性地与储存器（160）连通。 该装置还包括用于选择性地加压储存器（160）的加压系统（600,140）。 在预启动位置，加压系统（600,140）接触和压缩储存器（160）以减小储存器（160）的初始容积，从而允许储存器（160）的部分填充。
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公开(公告)号：US08961469B2
公开(公告)日：2015-02-24
申请号：US13516540
申请日：2009-12-16
申请人： Ralph Sonderegger , Lionel Vedrine , Curt Bingham , Bart Peterson
发明人： Ralph Sonderegger , Lionel Vedrine , Curt Bingham , Bart Peterson
CPC分类号： A61M5/14248 , A61M5/14244 , A61M5/1626 , A61M5/3202 , A61M5/3213 , A61M2005/1416
摘要： A drug delivery device (100), including a body (104, 116) having a reservoir (164, 176) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (164, 176) and the patient. The device (100) also includes a needle cover (114) for selectively covering the injection needle (152), an adhesive (264) for selectively adhering the device to the patient, a release liner (500) for selectively covering a patient side of the adhesive (264), and a connecting means (112, 520, 512, 508, 524) for connecting the needle cover (114) and the release liner (500) such that removal of one of the needle cover (114) and the release liner (500) from the device (100) removes the other one of the needle cover (114) and the release liner (500).
摘要翻译： 一种药物输送装置（100），包括具有设置在其中的用于容纳药物的储存器（164,176）的主体（104,116）和用于穿透患者皮肤的注射针（152），所述针（152） 为储存器（164,176）和患者之间的药物提供路径。 装置（100）还包括用于选择性地覆盖注射针（152）的针罩（114），用于选择性地将装置粘附到患者的粘合剂（264），用于选择性地覆盖患者侧的剥离衬垫 粘合剂（264）和用于连接针罩（114）和释放衬垫（500）的连接装置（112,520,512,508,524），从而使针盖（114）和 脱离衬垫（500）从装置（100）移除针罩（114）和剥离衬垫（500）中的另一个。
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公开(公告)号：US20130006195A1
公开(公告)日：2013-01-03
申请号：US13516169
申请日：2009-12-16
申请人： Ralph Sonderegger , Curt Bingham , Lionel Vedrine
发明人： Ralph Sonderegger , Curt Bingham , Lionel Vedrine
IPC分类号： A61M5/315
CPC分类号： A61M5/14244 , A61M5/14586 , A61M5/2033 , A61M2005/14506 , A61M2005/1585
摘要： A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.
摘要翻译： 一种药物输送装置，包括其中设置有用于容纳药物的储存器的本体，所述储存器包括柔性壁; 柱塞，其可在所述主体内移动以使所述药物从所述储存器排出，所述柱塞具有未固定到所述柔性储存器壁的接触表面; 弹簧将柱塞偏压到储存器; 以及用于相对于所述储存器选择性地将所述柱塞保持在预启动位置并且在将所述柱塞从所述预启动位置释放时引导所述柱塞在所述弹簧的力作用下移动的装置， 柱塞接触柔性储存器壁以对储存器加压以将药物递送到患者。
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公开(公告)号：US20120316506A1
公开(公告)日：2012-12-13
申请号：US13516540
申请日：2009-12-16
申请人： Ralph Sonderegger , Lionel Vedrine , Curt Bingham , Bart Peterson
发明人： Ralph Sonderegger , Lionel Vedrine , Curt Bingham , Bart Peterson
IPC分类号： A61M5/32
CPC分类号： A61M5/14248 , A61M5/14244 , A61M5/1626 , A61M5/3202 , A61M5/3213 , A61M2005/1416
摘要： A drug delivery device (100), including a body (104, 116) having a reservoir (164, 176) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (164, 176) and the patient. The device (100) also includes a needle cover (114) for selectively covering the injection needle (152), an adhesive (264) for selectively adhering the device to the patient, a release liner (500) for selectively covering a patient side of the adhesive (264), and a connecting means (112, 520, 512, 508, 524) for connecting the needle cover (114) and the release liner (500) such that removal of one of the needle cover (114) and the release liner (500) from the device (100) removes the other one of the needle cover (114) and the release liner (500).
摘要翻译： 一种药物输送装置（100），包括具有设置在其中的用于容纳药物的储存器（164,176）的主体（104,116）和用于穿透患者皮肤的注射针（152），所述针（152） 为储存器（164,176）和患者之间的药物提供路径。 装置（100）还包括用于选择性地覆盖注射针（152）的针罩（114），用于选择性地将装置粘附到患者的粘合剂（264），用于选择性地覆盖患者侧的剥离衬垫 粘合剂（264）和用于连接针罩（114）和释放衬垫（500）的连接装置（112,520,512,508,524），从而使针盖（114）和 脱离衬垫（500）从装置（100）移除针罩（114）和剥离衬垫（500）中的另一个。
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公开(公告)号：US09579461B2
公开(公告)日：2017-02-28
申请号：US13516182
申请日：2009-12-16
CPC分类号： A61M5/2033 , A61M5/14244 , A61M5/14586 , A61M5/148 , A61M37/0015 , A61M2005/14506 , A61M2005/1585 , A61M2037/0023
摘要： A drug delivery device (100) includes a body (102, 116) having a reservoir (160) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (160) and the patient. The device (100) also includes a plunger (144) movable within the body (102, 116) for causing the medicament to be expelled from the reservoir (160), and a biasing means (140) for biasing the plunger (144) toward the reservoir (160), wherein in a pre-activated position, the biasing means (140) telescopes within itself, and upon activation, provides a force to the plunger (144) for expelling the medicament from the reservoir (160). The biasing means (140) is preferably provided in the form of a conical spring having a variable pitch.
摘要翻译： 药物输送装置（100）包括具有设置在其中的用于容纳药物的储存器（160）和用于穿透患者皮肤的注射针（152）的主体（102,116），所述针（152）提供路径 用于储存器（160）和患者之间的药物。 装置（100）还包括可在主体（102,116）内移动的柱塞（144），用于使药物从储存器（160）排出;以及偏置装置（140），用于将柱塞（144）朝向 所述储存器（160），其中在预启动位置中，所述偏置装置（140）在其内部望远镜，并且在启动时，向所述柱塞（144）提供用于从所述储存器（160）排出所述药物的力。 偏置装置（140）优选地以具有可变间距的锥形弹簧的形式设置。
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公开(公告)号：US08444604B2
公开(公告)日：2013-05-21
申请号：US10567051
申请日：2004-08-12
申请人： Chris Cindrich , Ralph Sonderegger , Glade Howell , Weston Harding , Alex Lastovich , Lionel Vedrine
发明人： Chris Cindrich , Ralph Sonderegger , Glade Howell , Weston Harding , Alex Lastovich , Lionel Vedrine
IPC分类号： A61M5/32
CPC分类号： A61M5/158 , A61M5/14248 , A61M5/145 , A61M5/16804 , A61M2005/14256 , A61M2005/1426 , A61M2005/14506 , A61M2005/1583 , A61M2005/1585 , A61M2209/06
摘要： A system and method for a patch-like, self-contained substance infusion device (700) which can be attached to a skin surface via an adhesive contact surface. A push button (780) activation assembly can then be used to remove an interlock (730), allowing a disk or Belleville spring (735) assembly to apply an essentially even and constant pressure to the contents of a fluid reservoir assembly (710). This allows the release of one or more spring-loaded patient needles (760) into the skin surface, and establishes a fluid communication path between the patient needles (760) and the pressurized fluid reservoir contents thereby delivering an infusion into the skin. The push button (780) activation assembly further allows the release of one or more improved safety mechanisms (794) after use.
摘要翻译： 一种用于贴片状独立物质输注装置（700）的系统和方法，其可经由粘合剂接触表面附着于皮肤表面。 然后可以使用按钮（780）激活组件来移除互锁（730），允许盘或贝氏弹簧（735）组件对流体储存器组件（710）的内容物施加基本均匀且恒定的压力。 这允许一个或多个弹簧加载的患者针（760）释放到皮肤表面中，并且在患者针（760）和加压流体储存器内容物之间建立流体连通路径，从而将输注输送到皮肤中。 按钮（780）启动组件进一步允许在使用之后释放一个或多个改进的安全机构（794）。
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公开(公告)号：US20080215015A1
公开(公告)日：2008-09-04
申请号：US10567051
申请日：2004-08-12
申请人： Chris Cindrich , Ralph Sonderegger , Glade Howell , Weston Harding , Alex Lastovich , Lionel Vedrine
发明人： Chris Cindrich , Ralph Sonderegger , Glade Howell , Weston Harding , Alex Lastovich , Lionel Vedrine
CPC分类号： A61M5/158 , A61M5/14248 , A61M5/145 , A61M5/16804 , A61M2005/14256 , A61M2005/1426 , A61M2005/14506 , A61M2005/1583 , A61M2005/1585 , A61M2209/06
摘要： A system and method for a patch-like, self-contained substance infusion device (700) which provides one or more substantially hidden patient needles (760) which can be placed in fluid communication with a fluid reservoir assembly (710) that includes a rigid bladder portion (712) used in conjunction with a non-distensible bladder film (740), such as a metallized film. The device (700) can be attached to a skin surface via an adhesive contact surface and a push button (780) activation assembly can then be used to remove an interlock (730), allowing a disk, or Belleville spring (735) assembly to apply an essentially even and constant pressure to the contents of a fluid reservoir assembly (710). The push button (780) activation assembly further allows the release of one or more spring-loaded patient needles (760) into the skin surface, and establishes a fluid communication path between the patient needles (760) and the pressurized fluid reservoir contents thereby delivering an infusion into the skin. The push button (780) activation assembly further allows the release of one or more improved safety mechanisms (794) after use which are driven by spring (793) and released by trap-door (790).
摘要翻译： 一种用于贴片状独立物质输注装置（700）的系统和方法，其提供一个或多个基本上隐藏的患者针（760），其可以与包括刚性的流体储存器组件（710）流体连通 与不扩张的膀胱膜（740）结合使用的气囊部分（712），例如金属化膜。 装置（700）可以经由粘合剂接触表面附接到皮肤表面，然后可以使用按钮（780）启动组件来移除互锁（730），允许盘或贝氏弹簧（735）组件 对流体储存器组件（710）的内容物施加基本均匀和恒定的压力。 按钮（780）启动组件还允许一个或多个弹簧加载的患者针（760）释放到皮肤表面中，并且在患者针（760）和加压流体储存器内容物之间建立流体连通路径，由此递送 输入皮肤。 按钮（780）启动组件进一步允许释放一个或多个改进的安全机构（794），其被使用后由弹簧（793）驱动并且由收集门（790）释放。
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公开(公告)号：US20130006196A1
公开(公告)日：2013-01-03
申请号：US13516182
申请日：2009-12-16
IPC分类号： A61M5/315
CPC分类号： A61M5/2033 , A61M5/14244 , A61M5/14586 , A61M5/148 , A61M37/0015 , A61M2005/14506 , A61M2005/1585 , A61M2037/0023
摘要： A drug delivery device (100) includes a body (102, 116) having a reservoir (160) disposed therein for containing a medicament and an injection needle (152) for penetrating the skin of a patient, the needle (152) providing a path for the medicament between the reservoir (160) and the patient. The device (100) also includes a plunger (144) movable within the body (102, 116) for causing the medicament to be expelled from the reservoir (160), and a biasing means (140) for biasing the plunger (144) toward the reservoir (160), wherein in a pre-activated position, the biasing means (140) telescopes within itself, and upon activation, provides a force to the plunger (144) for expelling the medicament from the reservoir (160). The biasing means (140) is preferably provided in the form of a conical spring having a variable pitch.
摘要翻译： 药物输送装置（100）包括具有设置在其中的用于容纳药物的储存器（160）和用于穿透患者皮肤的注射针（152）的主体（102,116），所述针（152）提供路径 用于储存器（160）和患者之间的药物。 装置（100）还包括可在主体（102,116）内移动的柱塞（144），用于使药物从储存器（160）排出;以及偏置装置（140），用于将柱塞（144）朝向 所述储存器（160），其中在预启动位置中，所述偏置装置（140）在其内部望远镜，并且在启动时，向所述柱塞（144）提供用于从所述储存器（160）排出所述药物的力。 偏置装置（140）优选地以具有可变间距的锥形弹簧的形式设置。
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