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公开(公告)号:US06268343B1
公开(公告)日:2001-07-31
申请号:US09258750
申请日:1999-02-26
申请人: Liselotte Bjerre Knudsen , Per Olaf Huusfeldt , Per Franklin Nielsen , Niels C. Kaarsholm , Helle Birk Olsen , Søren Erik Bjørn , Freddy Zimmerdahl Pedersen , Kjeld Madsen
发明人: Liselotte Bjerre Knudsen , Per Olaf Huusfeldt , Per Franklin Nielsen , Niels C. Kaarsholm , Helle Birk Olsen , Søren Erik Bjørn , Freddy Zimmerdahl Pedersen , Kjeld Madsen
IPC分类号: A61K3916
CPC分类号: C11D3/168 , A61K38/2264 , A61K38/26 , A61K38/28 , C07K14/605 , C11D3/0063 , A61K2300/00
摘要: The present invention relates to GLP-1 derivatives having a lipophilic substituent, pharmaceutical compositions comprising same, and methods of making an using same. The GLP-1 derivatives of the present invention have a protracted profile of action.
摘要翻译: 本发明涉及具有亲油性取代基的GLP-1衍生物,包含其的药物组合物及其使用方法。 本发明的GLP-1衍生物具有延长的作用。
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公开(公告)号:US20090176700A1
公开(公告)日:2009-07-09
申请号:US11944757
申请日:2007-11-26
申请人: Liselotte Bjerre Knudsen , Per Olaf Huusfeldt , Per Franklin Nielsen , Niels C. Kaarsholm , Helle Birk Olsen , Soren Erik Bjorn , Freddy Zimmerdahl Pedersen , Kjeld Madsen
发明人: Liselotte Bjerre Knudsen , Per Olaf Huusfeldt , Per Franklin Nielsen , Niels C. Kaarsholm , Helle Birk Olsen , Soren Erik Bjorn , Freddy Zimmerdahl Pedersen , Kjeld Madsen
IPC分类号: A61K38/16
CPC分类号: C11D3/168 , A61K31/426 , A61K31/4439 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/24 , C07K14/605 , C11D3/0063 , A61K2300/00
摘要: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
摘要翻译: 本发明涉及包含具有亲脂性取代基的GLP-1衍生物的药物组合物; 和表面活性剂。
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公开(公告)号:US08097698B2
公开(公告)日:2012-01-17
申请号:US11944757
申请日:2007-11-26
申请人: Liselotte Bjerre Knudsen , Per Olaf Huusfeldt , Per Franklin Nielsen , Niels C. Kaarsholm , Helle Birk Olsen , Soren Erik Bjorn , Freddy Zimmerdahl Pedersen , Kjeld Madsen
发明人: Liselotte Bjerre Knudsen , Per Olaf Huusfeldt , Per Franklin Nielsen , Niels C. Kaarsholm , Helle Birk Olsen , Soren Erik Bjorn , Freddy Zimmerdahl Pedersen , Kjeld Madsen
IPC分类号: A61K38/16 , C07K14/605
CPC分类号: C11D3/168 , A61K31/426 , A61K31/4439 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/24 , C07K14/605 , C11D3/0063 , A61K2300/00
摘要: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
摘要翻译: 本发明涉及包含具有亲脂性取代基的GLP-1衍生物的药物组合物; 和表面活性剂。
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公开(公告)号:US20080103097A1
公开(公告)日:2008-05-01
申请号:US11789953
申请日:2007-04-26
CPC分类号: C07K14/605 , A61K38/26 , A61K38/28 , C07K14/57563 , A61K2300/00
摘要: The present invention relates to a derivative of GLP-1(7-C), wherein C is 35 or 36 which derivative has just one lipophilic substituent which is attached to the C-terminal amino acid residue.
摘要翻译: 本发明涉及GLP-1(7-C)的衍生物,其中C为35或36,该衍生物仅具有一个与C末端氨基酸残基连接的亲油取代基。
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公开(公告)号:US07226990B2
公开(公告)日:2007-06-05
申请号:US09886311
申请日:2001-06-21
CPC分类号: C07K14/605 , A61K38/26 , A61K38/28 , C07K14/57563 , A61K2300/00
摘要: The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid residue, which is not the N-terminal or C-terminal amino acid residue of the derivative.
摘要翻译: 本发明涉及毒蜥外泌肽-4或毒蜥外泌肽-4片段的新衍生物,其中所述衍生物具有任选经由间隔基连接的亲脂性取代基与不是N-末端或C-末端氨基酸的氨基酸残基 衍生物残基。
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公开(公告)号:US06458924B2
公开(公告)日:2002-10-01
申请号:US09398111
申请日:1999-09-16
IPC分类号: A61K3816
CPC分类号: C11D3/168 , A61K38/26 , A61K38/28 , A61K47/24 , C07K14/605 , C11D3/0063 , A61K2300/00
摘要: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
摘要翻译: 本发明涉及包含具有亲脂性取代基的GLP-1衍生物的药物组合物; 和表面活性剂。
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公开(公告)号:US07235627B2
公开(公告)日:2007-06-26
申请号:US10285079
申请日:2002-08-19
IPC分类号: C07K14/605
CPC分类号: C11D3/168 , A61K31/426 , A61K31/4439 , A61K38/2264 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/24 , C07K14/605 , C11D3/0063 , A61K2300/00
摘要: The present invention relates to a pharmaceutical composition comprising a GLP-1 derivative having a lipophilic substituent; and a surfactant.
摘要翻译: 本发明涉及包含具有亲脂性取代基的GLP-1衍生物的药物组合物; 和表面活性剂。
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公开(公告)号:US20090011461A1
公开(公告)日:2009-01-08
申请号:US12040141
申请日:2008-02-29
申请人: Lars Thim , Kjeld Norris , Fanny Norris , Soren Erik Bjorn , Mogens Christensen , Per Franklin Nielsen
发明人: Lars Thim , Kjeld Norris , Fanny Norris , Soren Erik Bjorn , Mogens Christensen , Per Franklin Nielsen
IPC分类号: C12P21/04
CPC分类号: C07K14/575 , A61K38/00
摘要: Human spasmolytic polypeptide (HSP) which has the amino acid sequence Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile Phe Glu Val Pro Trp Cys Phe Phe Pro Asn Ser Val Glu Asp Cys His Tyror a functionally equivalent homologue thereof, characterized by being in glycosylated form.
摘要翻译: 具有氨基酸序列的人解痉多肽(HSP)Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile Phe Glu Val Pro Trp Cys Phe Phe Pro Asn Ser Val Glu Asp Cys His Tyr或其功能等同同系物,其特征在于呈糖基化形式。
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公开(公告)号:US5783416A
公开(公告)日:1998-07-21
申请号:US491976
申请日:1995-08-02
申请人: Lars Thim , Kjeld Norris , Fanny Norris , S.o slashed.ren Erik Bj.o slashed.rn , Mogens Christensen , Per Franklin Nielsen
发明人: Lars Thim , Kjeld Norris , Fanny Norris , S.o slashed.ren Erik Bj.o slashed.rn , Mogens Christensen , Per Franklin Nielsen
CPC分类号: C07K14/575 , A61K38/00
摘要: A human spasmolytic polypeptide (HSP) having the amino acid of SEQ ID NO:1, characterized by being in a glycosylated form.
摘要翻译: PCT No.PCT / DK94 / 00037 Sec。 371日期:1995年8月2日 102(e)日期1995年8月2日PCT 1994年1月20日PCT PCT。 第WO94 / 17102号公报 日期1994年8月4日具有SEQ ID NO:1的氨基酸的人解痉多肽(HSP),其特征在于是糖基化形式。
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公开(公告)号:US20100292444A1
公开(公告)日:2010-11-18
申请号:US12666395
申请日:2008-07-03
申请人: Jens Breinholt , Per Franklin Nielsen , Leif Christensen , Leif Nørskov-Lauritsen , Anders Swensson
发明人: Jens Breinholt , Per Franklin Nielsen , Leif Christensen , Leif Nørskov-Lauritsen , Anders Swensson
IPC分类号: C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00 , C07K16/00
CPC分类号: C07K14/57554
摘要: The present invention relates to prolactin analogues, which analogues have increased resistance to deamidation.
摘要翻译: 本发明涉及催乳素类似物,其类似物具有增加的脱酰胺抗性。
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