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    Human spasmolytic polypeptide in glycosylated form
    4.
    发明申请
    Human spasmolytic polypeptide in glycosylated form 审中-公开
    人解痉多肽以糖基化形式存在

    公开(公告)号：US20050287640A1

    公开(公告)日：2005-12-29

    申请号：US11139749

    申请日：2005-05-27

    申请人： Lars Thim ,  Kjeld Norris ,  Fanny Norris ,  Soren Bjorn ,  Mogens Christensen ,  Per Nielsen

    发明人： Lars Thim ,  Kjeld Norris ,  Fanny Norris ,  Soren Bjorn ,  Mogens Christensen ,  Per Nielsen

    IPC分类号： A61K38/00 ,  C07K14/575 ,  C12N15/12 ,  C12P21/06 ,  C12N1/18

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： Human spasmolytic polypeptide (HSP) which has the amino acid sequence Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro His Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile Thr Ser Asp Gln Cys Phe Asp Asn Gly Cys Cys Phe Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Ser Asn Phe Ile Phe Glu Val Pro Trp Cys Phe Phe Pro Asn Ser Val Glu Asp Cys His Tyr or a functionally equivalent homologue thereof, characterized by being in glycosylated form.

    摘要翻译： 具有氨基酸序列

    Glu Lys Pro Ser Pro Cys Gln Cys Ser Arg Leu Ser Pro他的Asn Arg Thr Asn Cys Gly Phe Pro Gly Ile ROW> <进入> Asp Ser Ser Val Thr Gly Val Pro Trp Cys Phe His < 进入> Pro Leu Pro Lys Gln Glu Ser Asp Gln Cys Val Met Glu Val Ser Asp Arg Arg Asn Cys Gly Tyr Pro Gly Ile Ser Pro Glu Glu Cys Ala Ser Arg Lys Cys Cys Phe Pro Asn Ser Val Glu Asp Cys His Tyr 或其功能等同同系物，其特征在于呈糖基化形式。

      Inhibition of bradykinin release
      9.
      发明申请
      Inhibition of bradykinin release 审中-公开
      抑制缓激肽释放

      公开(公告)号：US20060154319A1

      公开(公告)日：2006-07-13

      申请号：US11248110

      申请日：2005-10-11

      申请人： Hans Flodgaard ,  Lennart Lindbom ,  Soren Bjorn

      发明人： Hans Flodgaard ,  Lennart Lindbom ,  Soren Bjorn

      IPC分类号： A61K38/17 ,  G01N33/537 ,  G01N33/53 ,  G01N33/543

      CPC分类号： A61K38/57 ,  G01N33/5064 ,  G01N2333/575 ,  G01N2333/96433

      摘要： The invention is related to a method for treating or preventing a disorder resulting from the release of bradykinin in said mammal, particularly a mammal which produces a HBP which binds to a HBP antagonist, e.g. a monoclonal antibody that binds to at least one epitope of human HBP, comprising administering to said mammal a HBP antagonist in an amount effective to decrease the release of bradykinin in a mammal. Furthermore, the invention is directed to methods and kits for determining if a mammal produces HBP that binds to a HBP antagonist, e.g., a monoclonal antibody that binds to at least one epitope of human HBP and a method for detecting an antagonist of HBP.

      摘要翻译： 本发明涉及用于治疗或预防所述哺乳动物，特别是产生结合HBP拮抗剂的HBP的哺乳动物例如缓释肽释放引起的疾病的方法，例如， 与人类HBP的至少一个表位结合的单克隆抗体，包括向所述哺乳动物施用有效降低哺乳动物缓激肽释放量的HBP拮抗剂。 此外，本发明涉及用于确定哺乳动物是否产生结合HBP拮抗剂的HBP的方法和试剂盒，例如与人HBP的至少一个表位结合的单克隆抗体和检测HBP拮抗剂的方法。