公开(公告)号：US20230191124A1

公开(公告)日：2023-06-22

申请号：US18083057

申请日：2022-12-16

Applicant: LivaNova USA, Inc.

Inventor： Stephen L. Bolea ,  Thomas B. Hoegh ,  Brian D. Kuhnley ,  Dale G. Suilmann ,  Bruce J. Persson ,  John P. Beck ,  Sidney F. Hauschild ,  Wondimeneh Tesfayesus ,  Jason J. Skubitz ,  Mark R. Bosshard ,  Daniel A. Parrish ,  Robert E. Atkinson

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372

CPC classification number: A61N1/3601 ,  A61N1/0556 ,  A61N1/3611 ,  A61N1/36139 ,  A61N1/37235 ,  A61N1/3615 ,  A61N1/36132 ,  A61B5/0809

Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.

公开(公告)号：USRE48024E1

公开(公告)日：2020-06-02

申请号：US14681764

申请日：2015-04-08

Applicant: LivaNova USA, Inc.

Inventor： Stephen L. Bolea ,  Thomas B. Hoegh ,  Bruce J. Persson ,  Robert E. Atkinson ,  Sidney F. Hauschild ,  Paula M. Kaplan ,  Brian D. Kuhnley ,  Keith E. Jasperson ,  Wondimeneh Tesfayesus ,  Christopher K. Thorp

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  A61B5/08 ,  A61B5/00

Abstract: Devices, systems and methods for nerve stimulation for OSA therapy.

公开(公告)号：US11529514B2

公开(公告)日：2022-12-20

申请号：US15918519

申请日：2018-03-12

Applicant: LivaNova USA, Inc.

Inventor： Stephen L. Bolea ,  Thomas B. Hoegh ,  Brian D. Kuhnley ,  Dale G. Suilmann ,  Bruce J. Persson ,  John P. Beck ,  Sidney F. Hauschild ,  Wondimeneh Tesfayesus ,  Jason J. Skubitz ,  Mark R. Bosshard ,  Daniel A. Parrish ,  Robert E. Atkinson

IPC: A61N1/36 ,  A61N1/05 ,  A61B5/08 ,  A61B5/00 ,  A61N1/372

Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.

公开(公告)号：US10737094B2

公开(公告)日：2020-08-11

申请号：US16164551

申请日：2018-10-18

Applicant: LivaNova USA, Inc.

Inventor： Stephen L. Bolea ,  Thomas B. Hoegh ,  Brian D. Kuhnley ,  Dale G. Suilmann ,  Bruce J. Persson ,  John P. Beck ,  Sidney F. Hauschild ,  Paula M. Kaplan ,  Adam K. Hoyhtya ,  Wondimeneh Tesfayesus ,  Robert E. Atkinson

IPC: A61N1/36 ,  A61B5/053 ,  A61B5/00 ,  A61N1/05

Abstract: Devices, systems and methods of neurostimulation for treating obstructive sleep apnea.

公开(公告)号：USRE48025E1

公开(公告)日：2020-06-02

申请号：US14693836

申请日：2015-04-22

Applicant: LivaNova USA, Inc.

Inventor： Stephen L. Bolea ,  Thomas B. Hoegh ,  Bruce J. Persson ,  Robert E. Atkinson ,  Sidney F. Hauschild ,  Paula M. Kaplan ,  Brian D. Kuhnley ,  Keith E. Jasperson ,  Wondimeneh Tesfayesus ,  Christopher K. Thorp

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/372 ,  A61B5/08 ,  A61B5/00

Abstract: In one embodiment, a method for maintaining patency of an upper airway of a patient to treat obstructive sleep apnea may include delivering an electrical stimulation to a portion of a superior laryngeal nerve via a nerve cuff when the nerve cuff is adjacent an external surface of the superior laryngeal nerve, the nerve cuff having a plurality of electrodes, wherein the nerve cuff is configured to be connected to an electrical stimulator via a stimulation lead.

公开(公告)号：US10231645B2

公开(公告)日：2019-03-19

申请号：US15418467

申请日：2017-01-27

Applicant: LivaNova USA, Inc.

Inventor： Wondimeneh Tesfayesus ,  Stephen L. Bolea ,  Peter R. Eastwood ,  David R. Hillman

IPC: A61N1/00 ,  A61B5/08 ,  A61N1/36 ,  A61N1/05 ,  A61B1/233 ,  A61B5/00 ,  A61B1/267

Abstract: Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.

公开(公告)号：US11000208B2

公开(公告)日：2021-05-11

申请号：US16355341

申请日：2019-03-15

Applicant: LivaNova USA, Inc.

Inventor： Wondimeneh Tesfayesus ,  Stephen L. Bolea ,  Peter R. Eastwood ,  David R. Hillman

IPC: A61B1/267 ,  A61B5/08 ,  A61N1/36 ,  A61N1/05 ,  A61B1/233 ,  A61B5/00

Abstract: Devices and methods for treating obstructive sleep apnea by first performing an assessment of the patient that involves observing the patient's upper airway during a tongue protrusion maneuver. The assessment may, for example, be done using endoscopy to observe the upper airway while the patient is awake in the supine position. An adequate response of the upper airway during the tongue protrusion maneuver is indicative of likely therapeutic success with hypoglossal nerve stimulation, and may be used for making clinical decisions. The principles of the present invention may be applied to other therapeutic interventions for OSA involving the upper airway.

公开(公告)号：US20200254245A1

公开(公告)日：2020-08-13

申请号：US16858490

申请日：2020-04-24

Applicant: LivaNova USA, Inc.

Inventor： Stephen L. Bolea ,  Thomas B. Hoegh ,  Brian D. Kuhnley ,  Dale G. Suilmann ,  Bruce J. Persson ,  John P. Beck ,  Sidney Hauschild ,  Paula M. Kaplan ,  Adam K. Hoyhtya ,  Wondimeneh Tesfayesus ,  Robert E. Atkinson ,  Peter R. Eastwood ,  David R. Hillman

IPC: A61N1/36 ,  A61B5/053 ,  A61B5/00 ,  A61N1/05

Abstract: An implantable neurostimulation system comprises a stimulation delivery lead and a neurostimulator. The stimulation delivery lead is coupled to an electrode. The neurostimulator is adapted to deliver a neurostimulation signal to the subject and comprises a microprocessor. The microprocessor is programmed to identify a stimulation operating window for the therapy including a first threshold and a second threshold. The second threshold comprises an awake level and an asleep level. Identifying the stimulation operating window comprises titrating a stimulation setting of the neurostimulator while the subject is awake until the first threshold and the awake level of the second threshold are identified. Identifying the stimulation operating window further comprises subsequently repeating the step of titrating the stimulation setting of the neurostimulator while the subject is asleep until the asleep level of the second threshold is identified.