-
1.发明授权3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease 失效可用于治疗阿尔茨海默氏病的3-（5-异恶唑基）-1-甲基-1,2,3,6-四氢吡啶
公开(公告)号：US5356912A
公开(公告)日：1994-10-18
申请号：US151402
申请日：1993-11-12
IPC分类号： A61K31/42 , A61K31/435 , A61K31/445 , A61K31/46 , A61P25/28 , C07D211/70 , C07D211/72 , C07D413/04 , C07D451/02 , C07D451/04 , C07D453/02 , A61K31/44
CPC分类号： C07D451/02 , C07D211/70 , C07D211/72 , C07D413/04 , C07D451/04 , C07D453/02
摘要： Novel azacyclic compounds selected from the group consisting of ##STR1## wherein R.sup.1 is H or C.sub.1-6 -alkylR.sup.3 is ##STR2## R" is H or C.sub.1-8 -alkyl or C.sub.1-6 -alkoxy or C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl or aryl, andR.sup.4 is H, C.sub.1-8 -alkyl or Cl;and a salt thereof with a pharmaceutically-acceptable acid.The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease.
摘要翻译： 选自由下列组成的组的新型氮杂环烷化合物：其中R 1为H或C 1-6 - 烷基R 3为H或C 1-8 - 烷基或C 1-6 - 烷氧基或C 1-8 - 4-烷氧基-C 1-4 - 烷基或芳基，并且R 4是H，C 1-8 - 烷基或Cl; 及其与药学上可接受的酸的盐。 新化合物可用于改善哺乳动物前脑和海马的认知功能，可用于治疗阿尔茨海默病。
-
2.发明授权3-substituted and optionally 1-substituted azacyclic or azabicyclic compounds, pharmaceutical compositions, thereof and their use as stimulants of cognitive functions 失效3-取代的和任选的1-取代的氮杂环或氮杂双环化合物，其药物组合物及其作为认知功能的兴奋剂的用途
公开(公告)号：US5262427A
公开(公告)日：1993-11-16
申请号：US268940
申请日：1988-11-08
IPC分类号： A61K31/42 , A61K31/435 , A61K31/445 , A61K31/46 , A61P25/28 , C07D211/70 , C07D211/72 , C07D413/04 , C07D451/02 , C07D451/04 , C07D453/02 , A61K31/41
CPC分类号： C07D451/02 , C07D211/70 , C07D211/72 , C07D413/04 , C07D451/04 , C07D453/02
摘要： Azacyclic compounds selected from the group consisting of ##STR1## wherein R.sup.1 is H or C.sub.1-6 -alkylR.sup.3 is ##STR2## wherein R' is C.sub.3-8 -alkyl, cyclopropyl, C.sub.4-8 -cycloalkyl, benzyl which may be substituted, or C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl, andR" is H or C.sub.1-8 -alkyl or C.sub.1-6 -alkoxy or C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl or aryl, andR'" is H or C.sub.1-6 -alkyl or C.sub.4-8 -cycloalkyl; andR.sup.4 is H, C.sub.1-8 -alkyl or Cl; and ##STR3## provided that R.sup.3 is not ##STR4## wherein R' is C.sub.3-8 -alkyl, cyclopropyl or C.sub.1-3 -alkoxymethyl, and provided that R.sup.3 is not --CH.dbd.N--OR'", wherein R'" is H or C.sub.1-6 -alkyl, when the compounds of formula I is ##STR5## and a salt thereof with a pharmaceutically-acceptable acid. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease.
-
公开(公告)号：US5914338A
公开(公告)日：1999-06-22
申请号：US831358
申请日：1997-04-01
申请人： Lone Jeppesen , Preben H. Olesen , Per Sauerberg
发明人： Lone Jeppesen , Preben H. Olesen , Per Sauerberg
IPC分类号： A61K31/00 , A61K31/41 , A61P1/00 , A61P1/14 , A61P9/10 , A61P13/10 , A61P15/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/00 , A61P27/06 , A61P43/00 , C07D487/08 , C07D285/10 , C07D417/04
CPC分类号： C07D487/08
摘要： The present invention relates to therapeutically active azatricyclic compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a disease in the central nervous system caused by malfunctioning of the muscarinic cholinergic system.
摘要翻译： 本发明涉及式I的治疗活性氮杂环化合物，其制备方法和包含该化合物的药物组合物。 新化合物可用于治疗由毒蕈碱胆碱能系统功能障碍引起的中枢神经系统疾病。
-
公开(公告)号：US5773452A
公开(公告)日：1998-06-30
申请号：US513851
申请日：1995-10-31
IPC分类号： A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/5377 , A61P25/04 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/44
CPC分类号： C07D413/04 , C07D417/04 , C07D417/14 , Y10S514/913
摘要： The present invention relates to therapeutically active azabicyclic compounds of formula (1), wherein Z1 is oxygen or sulphur, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma. ##STR1##
摘要翻译： PCT No.PCT / DK94 / 00095 Sec。 371日期1995年10月31日 102（e）日期1995年10月31日PCT 1994年4月4日PCT PCT。 出版物WO94 / 20495 日期：1994年9月15日本发明涉及治疗活性的式（1）的氮杂双环化合物，其中Z1是氧或硫，其制备方法和包含该化合物的药物组合物。 新化合物可用作哺乳动物前脑和海马的认知功能的兴奋剂，特别是治疗阿尔茨海默病，严重的疼痛病症和青光眼。 （一）
-
公开(公告)号：US5712297A
公开(公告)日：1998-01-27
申请号：US717647
申请日：1996-09-23
申请人： Per Sauerberg , Preben H. Olesen
发明人： Per Sauerberg , Preben H. Olesen
IPC分类号： A61K31/4427 , A61K31/445 , A61P25/02 , A61P25/04 , A61P25/28 , A61P27/02 , A61P27/06 , C07D211/70 , C07D285/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/44
CPC分类号： C07D413/04 , C07D417/04
摘要： The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
摘要翻译： 本发明涉及治疗活性哌啶化合物，其制备方法和包含该化合物的药物组合物。 新化合物可用作哺乳动物的前脑和海马的认知功能的兴奋剂，特别是在治疗阿尔茨海默病，严重的疼痛病症和青光眼中。
-
公开(公告)号：US5658932A
公开(公告)日：1997-08-19
申请号：US453605
申请日：1995-05-30
IPC分类号： A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/5377 , A61P25/04 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/42 , A61K31/425
CPC分类号： C07D413/04 , C07D417/04 , C07D417/14 , Y10S514/913
摘要： The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
摘要翻译： 本发明涉及治疗活性的azacyclic化合物，其制备方法和包含该化合物的药物组合物。 新化合物可用作哺乳动物的前脑和海马的认知功能的兴奋剂，特别是在治疗阿尔茨海默病，严重的疼痛病症和青光眼中。
-
公开(公告)号：US5559136A
公开(公告)日：1996-09-24
申请号：US455300
申请日：1995-05-30
IPC分类号： A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/5377 , A61P25/04 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/44 , A61K31/41 , A61K31/425
CPC分类号： C07D413/04 , C07D417/04 , C07D417/14 , Y10S514/913
摘要： The present invention relates to therapeutically active azacyclic compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
-
公开(公告)号：US5328923A
公开(公告)日：1994-07-12
申请号：US744150
申请日：1991-08-13
申请人： Per Sauerberg , Preben H. Olesen
发明人： Per Sauerberg , Preben H. Olesen
IPC分类号： A61K31/435 , A61K31/4245 , A61K31/433 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/44
CPC分类号： C07D413/04 , C07D417/04
摘要： The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
摘要翻译： 本发明涉及治疗活性的azacyclic化合物，其制备方法和包含该化合物的药物组合物。 新化合物可用作哺乳动物的前脑和海马的认知功能的兴奋剂，特别是在治疗阿尔茨海默病，严重的疼痛病症和青光眼中。
-
公开(公告)号：US5591755A
公开(公告)日：1997-01-07
申请号：US472350
申请日：1995-06-07
申请人： Per Sauerberg , Preben H. Olesen
发明人： Per Sauerberg , Preben H. Olesen
IPC分类号： A61K31/435 , A61K31/4245 , A61K31/433 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P43/00 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/44
CPC分类号： C07D413/04 , C07D417/04
摘要： The present invention relates to therapeutically active azacyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
摘要翻译： 本发明涉及治疗活性的azacyclic化合物，其制备方法和包含该化合物的药物组合物。 新化合物可用作哺乳动物的前脑和海马的认知功能的兴奋剂，特别是在治疗阿尔茨海默病，严重的疼痛病症和青光眼中。
-
10.发明授权Certain 1-azabicyclo[3.3.1]nonene derivatives and their pharmacological uses 失效某些1-氮杂双环[3.3.1]壬烯衍生物及其药理用途
公开(公告)号：US5578602A
公开(公告)日：1996-11-26
申请号：US450838
申请日：1995-05-25
申请人： Per Sauerberg , Preben H. Olesen
发明人： Per Sauerberg , Preben H. Olesen
IPC分类号： C07D451/02 , C07D451/04 , C07D453/02 , C07D471/08 , C07D487/08 , C07D451/14 , A61K31/435 , A61K31/46
CPC分类号： C07D451/04 , C07D451/02 , C07D453/02 , C07D471/08 , C07D487/08
摘要： The present invention relates to therapeutically active azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.
摘要翻译： 本发明涉及治疗活性的氮杂双环化合物，其制备方法和包含该化合物的药物组合物。 新化合物可用作哺乳动物的前脑和海马的认知功能的兴奋剂，特别是在治疗阿尔茨海默病，严重的疼痛病症和青光眼中。
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.028 秒)
