公开(公告)号：US20210324139A1

公开(公告)日：2021-10-21

申请号：US17273386

申请日：2019-09-04

申请人： Lonza Guangzhou Nansha Ltd. ,  Lonza Ltd

发明人： Dieter Scherer ,  Benjamin Wyler ,  Jieping Wei ,  Yanling Yang ,  Daniel Shan ,  Reta Zhu ,  Paul Hanselmann ,  Tania Kjellerup Lind ,  Emelie Josefina Nilsson ,  Vitaly Kocherbitov ,  Johan Engblom

IPC分类号： C08G65/332

摘要： The invention discloses a method for preparation of polyoxyethylene 1,4-sorbitan fatty acid ester, such as Polysorbate 80, by a reaction of polyoxyethylene 1,4-sorbitan with a fatty acid chloride, and polyoxyethylene 1,4-sorbitan fatty acid esters obtainable by this method.

公开(公告)号：US11174236B2

公开(公告)日：2021-11-16

申请号：US17265939

申请日：2019-08-26

申请人： Lonza Guangzhou Pharmaceutical Ltd. ,  Lonza Ltd

发明人： Jieping Wei ,  Yanling Yang ,  Daniel Shan ,  Reta Zhu ,  Paul Hanselmann ,  Dieter Scherer

IPC分类号： C07D307/20

摘要： The invention discloses a method for preparation of 1,4-sorbitan by dehydration of D-sorbitol, wherein one equivalent of water is removed and a cyclization occurs, followed by a treatment with ethanol and isopropanol.