公开(公告)号：US20180258136A1

公开(公告)日：2018-09-13

申请号：US15933800

申请日：2018-03-23

申请人： LONZA LTD ,  LONZA GUANGZHOU NANSHA LTD.

发明人： Laurent Ducry ,  Bernhard Stump ,  Heilam Wong ,  Jin She ,  Gayle Allway

IPC分类号： C07K5/062 ,  A61K47/68 ,  A61K47/65 ,  A61K47/64 ,  A61K47/60

CPC分类号： C07K5/06043 ,  A61K47/60 ,  A61K47/64 ,  A61K47/65 ,  A61K47/6809 ,  A61K47/6845

摘要： The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.

公开(公告)号：US20210324139A1

公开(公告)日：2021-10-21

申请号：US17273386

申请日：2019-09-04

申请人： Lonza Guangzhou Nansha Ltd. ,  Lonza Ltd

发明人： Dieter Scherer ,  Benjamin Wyler ,  Jieping Wei ,  Yanling Yang ,  Daniel Shan ,  Reta Zhu ,  Paul Hanselmann ,  Tania Kjellerup Lind ,  Emelie Josefina Nilsson ,  Vitaly Kocherbitov ,  Johan Engblom

IPC分类号： C08G65/332

摘要： The invention discloses a method for preparation of polyoxyethylene 1,4-sorbitan fatty acid ester, such as Polysorbate 80, by a reaction of polyoxyethylene 1,4-sorbitan with a fatty acid chloride, and polyoxyethylene 1,4-sorbitan fatty acid esters obtainable by this method.

公开(公告)号：US20210261514A1

公开(公告)日：2021-08-26

申请号：US17265939

申请日：2019-08-26

申请人： Lonza Guangzhou Nansha Ltd. ,  Lonza Ltd

发明人： Jieping WEI ,  Yanling YANG ,  Daniel SHAN ,  Reta ZHU ,  Paul HANSELMANN ,  Dieter SCHERER

IPC分类号： C07D307/20

摘要： The invention discloses a method for preparation of 1,4-sorbitan by dehydration of D-sorbitol, wherein one equivalent of water is removed and a cyclization occurs, followed by a treatment with ethanol and isopropanol.

公开(公告)号：US10214560B2

公开(公告)日：2019-02-26

申请号：US15933800

申请日：2018-03-23

申请人： LONZA LTD ,  LONZA GUANGZHOU NANSHA LTD.

发明人： Laurent Ducry ,  Bernhard Stump ,  Heilam Wong ,  Jin She ,  Gayle Allway

IPC分类号： A61K47/65 ,  C07K5/062 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68

摘要： The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is derived from o-hydroxy p-amino benzylic alcohol, wherein the peptide chain is connected to the phenyl ring via the p-amino group, the drug is connected to the phenyl ring via the benzylic alcohol moiety, and the protein is connected to the phenyl ring via the o-hydroxy group; further to a process for the preparation of said protein-drug-conjugates via various intermediates, to the pharmaceutical use of such protein drug conjugates, such as methods of controlling the growth of undesirable cells, to pharmaceutical compositions comprising such protein drug conjugates, and to intermediates of the preparation of the protein drug conjugates.