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    1-OXA-8-Azaspiro [4,5] Decabe-8-Carboxamide Compounds as FAAH Inhibitors
    5.
    发明申请
    1-OXA-8-Azaspiro [4,5] Decabe-8-Carboxamide Compounds as FAAH Inhibitors 审中-公开
    1-OXA-8-Azaspiro [4,5] Decabe-8-Carboxamide化合物作为FAAH抑制剂

    公开(公告)号：US20110230493A1

    公开(公告)日：2011-09-22

    申请号：US13129824

    申请日：2009-11-09

    申请人： Scott Allen Long ,  Marvin Jay Meyers ,  Matthew James Pelc ,  Barbara Ann Schweitzer ,  Lijuan Jane Wang ,  Atli Thorarensen

    发明人： Scott Allen Long ,  Marvin Jay Meyers ,  Matthew James Pelc ,  Barbara Ann Schweitzer ,  Lijuan Jane Wang ,  Atli Thorarensen

    IPC分类号： A61K31/501 ,  A61K31/438 ,  A61P9/00 ,  C07D491/107 ,  A61P19/02 ,  A61P3/10 ,  A61P29/00 ,  A61P9/12 ,  A61P11/06 ,  A61P1/00 ,  A61P25/00 ,  A61P35/04

    CPC分类号： C07D491/10

    摘要： Provided herein are 1-oxa-8-azaspiro[4.5]decane-8-carboxamide compounds of formula I wherein Ar1, Ar2, R1, R2, R3 and R4 are as defined herein and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.

    摘要翻译： 本文提供式I的1-氧杂-8-氮杂螺[4.5]癸烷-8-甲酰胺化合物，其中Ar 1，Ar 2，R 1，R 2，R 3和R 4如本文所定义，并且这些化合物的药学上可接受的盐可用于治疗疾病 或与脂肪酸酰胺水解酶（FAAH）活性相关的病症，包括急性疼痛，慢性疼痛，神经性疼痛，伤害性疼痛，炎性疼痛，纤维肌痛，类风湿性关节炎，炎性肠病，狼疮，糖尿病，过敏性哮喘，血管炎症，尿 失禁，膀胱过度活动，呕吐，认知障碍，焦虑症，抑郁症，睡眠障碍，进食障碍，运动障碍，青光眼，牛皮癣，多发性硬化，脑血管障碍，脑损伤，胃肠道疾病，高血压或心血管疾病。