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1.发明授权Process of preparing 3S-3-amino-3-aryl proprionic acid and derivatives thereof 有权制备3S-3-氨基-3-芳基丙酸及其衍生物的方法公开(公告)号：US06673926B2
公开(公告)日：2004-01-06
申请号：US10021369
申请日：2001-10-29
IPC分类号： C07D23902
CPC分类号： C07D213/55
摘要： The present invention is directed to a process for preparing 3S-3-amino-3-aryl propionic acid and derivatives thereof.
摘要翻译： 本发明涉及制备3S-3-氨基-3-芳基丙酸及其衍生物的方法。
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2.发明申请COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDENT GLUCOSE TRANSPORTER 有权具有抗依赖性葡萄糖输送机的抑制活性的化合物公开(公告)号：US20090029927A1
公开(公告)日：2009-01-29
申请号：US11949236
申请日：2007-12-03
IPC分类号： A61K31/7042 , A61P3/10 , C07H7/06
CPC分类号： C07D409/06
摘要： The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
摘要翻译： 本发明涉及本文所述的式（I）化合物，其药学上可接受的盐或其前药，以及药物组合物和治疗方法。
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公开(公告)号：US20090233874A1
公开(公告)日：2009-09-17
申请号：US12207252
申请日：2008-09-09
申请人： Ahmed F. Abdel-Magid , Maureen Chisholm , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
发明人： Ahmed F. Abdel-Magid , Maureen Chisholm , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
IPC分类号： A61K31/706 , C07H7/06 , A61P3/10
CPC分类号： C07D409/10 , C07D309/10 , C07D309/12 , C07D409/14 , C07D417/14
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
摘要翻译： 本发明涉及一种制备具有抑制活性的化合物的新方法，所述化合物对存在于肠或肾中的钠依赖性葡萄糖转运蛋白（SGLT）具有抑制活性。
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4.发明授权Compounds having inhibitory activity against sodium-dependent glucose transporter 有权对钠依赖性葡萄糖转运蛋白具有抑制活性的化合物公开(公告)号：US07666845B2
公开(公告)日：2010-02-23
申请号：US11949236
申请日：2007-12-03
IPC分类号： A61K31/7012 , C07H15/26 , A61P3/10
CPC分类号： C07D409/06
摘要： The invention is directed to compounds of the formula (I) described herein, a pharmaceutically acceptable salt thereof, or a prodrug thereof, and pharmaceutical compositions and methods of treatment.
摘要翻译： 本发明涉及本文所述的式（I）化合物，其药学上可接受的盐或其前药，以及药物组合物和治疗方法。
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5.发明授权Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-O-(1-methylethylidene)-.beta.-D-fructopyranose and (1-methylcyclohexyl)methanol 失效制备2,3,4,5-双-O-（1-甲基亚乙基）-β-D-吡喃葡萄糖和（1-甲基环己基）甲醇的氯磺酸盐和氨基磺酸盐衍生物的方法
公开(公告)号：US5387700A
公开(公告)日：1995-02-07
申请号：US106470
申请日：1993-08-12
IPC分类号： C07C307/02 , C07C303/34 , C07D309/06 , C07D493/04 , C07D493/14 , C07H9/04 , C07D311/78 , C07C309/02 , C07D311/94
CPC分类号： C07D493/04 , C07C303/34 , C07D309/06 , C07D493/14 , C07H9/04
摘要： A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-.beta.-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an alcohol with sulfuryl chloride in the presence of a tertiary or heterocyclic amine base in a solvent selected from the group consisting of toluene, t-butyl methyl ether or tetrahydrofuran to produce a chlorosulfate intermediate, which is preferably stabilized by an aqueous wash and/or treatment with a base, and in the second step reacting of the resulting intermediate with an amine in a solvent selected from the group consisting of t-butyl methyl ether, tetrahydrofuran and lower alkanol.
摘要翻译： 公开了一种制备2,3,4,5-双-O-（1-甲基亚乙基）-β-D-吡喃葡萄糖和（1-甲基环己基）甲醇的氯代硫酸盐和氨基磺酸酯的方法。 该方法涉及两步法，该方法包括在叔胺或杂环胺碱存在下，在选自甲苯，叔丁基甲基醚或四氢呋喃的溶剂中，将醇与磺酰氯反应的第一步骤，以产生 氯代硫酸盐中间体，其优选通过水性洗涤和/或用碱处理而稳定，并且在第二步中，将得到的中间体与胺在选自叔丁基甲基醚，四氢呋喃和低级 链烷醇
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6.发明授权公开(公告)号：US09024009B2
公开(公告)日：2015-05-05
申请号：US12207252
申请日：2008-09-09
申请人： Ahmed F. Abdel-Magid , Maureen Chislom , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
发明人： Ahmed F. Abdel-Magid , Maureen Chislom , Steven Mehrman , Lorraine Scott , Kenneth M. Wells , Fan Zhang-Plasket , Sumihiro Nomura , Mitsuya Hongu , Yuichi Koga
IPC分类号： C07H7/04 , C07H7/06 , C07D409/10 , C07D409/14 , C07D417/14 , A61K31/7042 , A61K31/7056 , A61K31/706 , A61P3/10 , C07D309/12 , C07D309/10
CPC分类号： C07D409/10 , C07D309/10 , C07D309/12 , C07D409/14 , C07D417/14
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
摘要翻译： 本发明涉及一种制备具有抑制活性的化合物的新方法，所述化合物对存在于肠或肾中的钠依赖性葡萄糖转运蛋白（SGLT）具有抑制活性。
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