摘要:
The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification below. The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
摘要:
The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification below. The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).
摘要翻译:本发明涉及制备通式(I)的四取代咪唑衍生物的方法,其中R 1,R 2,R 3和R 3, R 4如下面的说明书中所定义。 本发明还涉及制备式(II)化合物和式(II)化合物的新结晶结构的方法。
摘要:
Processes for the preparation of stable, crystalline cephalosporin intermediates of the formula ##STR1## wherein X is HI or HCl, and Nu and Nu.sup..sym. are certain N-containing heterocyclic rings attached via a sulfur atom or a ring nitrogen atom, respectively, which are substantially free of the .DELTA..sup.2 isomer; processes for intermediates in the preparation of the above compounds; and processes for the preparation of broad-spectrum cephalosporin antibiotics.
摘要:
The rear portion of a load hauling flatbed truck and the front portion of a conventional forklift vehicle are provided with structures facilitating towing of the forklift vehicle by the truck to a remote site so that the forklift vehicle is available for loading and/or unloading materials onto or from the flatbed truck. Basically, left and right rocking levers intermediately pivoted adjacent to left and right front corner portions of the forklift vehicle are hydraulically rocked so that the extending front portions of the rocking members engage about engagement structures secured adjacent to the left and right rear corners of the truck and thereby effect a lifting of the entire front portion of the forklift vehicle when the rocking members are rocked downwardly. Appropriate locking pins are inserted to secure the rocking members to the rear corner portions of the towing truck. The entire front wheels of the forklift vehicle are raised free of the ground so that towing operations result in only the rear wheels engaging the ground. The longitudinal fore and aft axes of the vehicle and truck remain in the same plane during towing operations.
摘要:
A brake lining wear indicator is attached to a drum brake shoe backing plate adjacent the brake lining. The indicator provides a visual gage dimension that assists in the determination of when the brake linings should be replaced. This determination can be made in a very short period of time without requiring a physical measurement of the thickness of the brake lining on each brake shoe.
摘要:
Temperature stable crystalline mono-hydrochloric and sulfuric acid addition salts of 7-amino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate substantially free of .DELTA..sup.2 isomer are intermediates for the preparation of broad spectrum 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinio)methyl]-3-cephem-4-carboxylates. The monohydrochloric acid addition salt intermediate is prepared by a process comprising the steps of (1) neutralizing diphenylmethyl 7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride, (2) reacting the resulting free base with benzaldehyde to produce diphenylmethyl 7-benzylideneamino-3-chloromethyl-3-cephem-4-carboxylate, (3) reacting the resulting product with sodium iodide to convert the chloromethyl group to iodomethyl, (4) reacting the resulting product with N-methylpyrrolidine to give the quaternized product diphenylmethyl 7-benzylideneamino-3-(1-methylpyrrolidinio)methyl-3-cephem-4-carboxylate iodide, and (5) reacting with hydrochloric acid to form said intermediate.
摘要:
The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds. More particularly, the present embodiments disclosed herein relate to novel side chains, that when coupled to a taxane, are useful for the synthesis of pharmaceutically useful taxanes. Methods of forming the novel side chains and coupling them to hindered alcohols, namely taxanes resulting in useful esters are also disclosed. Various taxanes compounds are known to exhibit anti-tumor activity.
摘要:
A unitary, rotary encoder disk provides low cost, ease of manufacture, and resolution capability exceeding through hole encoders and, in one embodiment, equivalent to that achieve in thin film technologies. The unitary construct is molded as a transparent polymer disk, with integrated mounting features. Either molded disk surface features or laser burning is used to facilitate the position graduation mark forming process.
摘要:
An improved camshaft sealing arrangement includes seals at each end of the camshaft housing. In addition, seals and washers are positioned between the camshaft and the slack adjuster connection. The combined seals provide a camshaft that is less likely to require maintenance than prior art camshafts. The seal adjacent the cam contacts an outer periphery of the camshaft housing. This seal also provides a thrust bearing washer surface against the camshaft. The seals between the camshaft and the slack adjuster include washers to properly secure and position the seals, the camshaft and the slack adjuster.