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1.发明授权Azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments 有权亚烷基取代的芳基噻吩并嘧啶酮，其制备方法及其作为药物的用途公开(公告)号：US08828991B2
公开(公告)日：2014-09-09
申请号：US12191630
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： C07D495/04 , A61K31/519 , C07D403/10 , C07D239/91 , C07D491/04 , A61K31/517 , A61K31/551 , A61P3/10 , A61P3/04 , C12N9/99
CPC分类号： C07D491/04 , C07D239/91 , C07D403/10 , C07D495/04 , C12N9/99
摘要： The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives, of the Formula (I); and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone according to Formula (I) or its derivative, and the use of the azacyclyl-substituted arylthienopyrimidinones according to Formula (I) and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物; 以及它们的生理学耐受的盐和生理功能衍生物及其制备方法，包含至少一种式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮或其衍生物的药物，以及根据式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物 作为MCH拮抗剂。
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2.发明授权Amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments 有权氨基醇取代的芳基噻吩并嘧啶酮，其制备方法及其用作药物公开(公告)号：US08853208B2
公开(公告)日：2014-10-07
申请号：US12191678
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00 , A61P3/10 , A61P3/04
CPC分类号： C07D495/04 , C07D519/00
摘要： The invention relates to amino alcohol-substituted arylthienopyrimidinones having a formula I and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及具有式I及其衍生物的氨基醇取代的芳基噻吩并嘧啶酮及其生理上耐受的盐和生理功能衍生物，其制备方法，包含本发明的至少一种氨基醇取代的芳基噻吩并嘧啶酮或其衍生物的药物及其用途 的本发明的氨基醇取代的芳基噻吩并嘧啶酮及其衍生物作为MCH拮抗剂。
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3.发明授权公开(公告)号：US08609731B2
公开(公告)日：2013-12-17
申请号：US12705140
申请日：2010-02-12
IPC分类号： A61K31/40 , A61K31/165 , C07C233/04 , C07C233/06
CPC分类号： C07D405/12 , A61K31/397 , A61K31/4025 , A61K31/4525 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D307/12
摘要： The invention relates to substituted tetrahydronaphthalenes and derivatives thereof, and also to the physiologically compatible salts and physiologically functional derivatives thereof, to preparation thereof, to medicaments comprising at least one inventive substituted tetrahydronaphthalene or derivative thereof, and to the use of the inventive substituted tetrahydronaphthalenes and derivatives thereof as medicaments.
摘要翻译： 本发明涉及取代的四氢萘及其衍生物，以及其生理上相容的盐和生理功能衍生物及其制备方法，涉及包含至少一种本发明取代的四氢化萘或其衍生物的药物，以及本发明取代的四氢萘和 其衍生物作为药物。
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4.发明授权Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments 有权偶氮酰基取代的芳基二氢异喹啉酮，其制备方法及其作为药物的用途公开(公告)号：US08822495B2
公开(公告)日：2014-09-02
申请号：US12191662
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4725 , C07D405/14 , C07D401/14 , C07D401/10 , C07D487/04 , C07D487/10 , C07D417/14 , C07D513/04 , C07D413/14 , C07D407/14 , C07D413/04
CPC分类号： A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/10 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氮杂环酰基取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氮杂环酰基取代的芳基二氢异喹啉酮或其衍生物的药物，以及使用偶氮基酰基取代的芳基二氢异喹啉酮 的本发明及其衍生物作为MCH拮抗剂。
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5.发明授权Aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments 有权氨基醇取代的芳基二氢异喹啉酮，其制备方法及其作为药物的用途公开(公告)号：US08501771B2
公开(公告)日：2013-08-06
申请号：US12191697
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： A01N43/42 , A61K31/47 , C07D217/22
CPC分类号： C07D471/04 , C07D217/24 , C07D401/12 , C07D451/06 , C07D453/02 , C07D455/06
摘要： The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氨基醇取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氨基醇取代的芳基二氢异喹啉酮或其衍生物的药物，以及氨基醇取代的芳基二氢异喹啉酮的用途 的本发明及其衍生物作为MCH拮抗剂。
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6.发明授权Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof 有权支链氧噻嗪衍生物，其制备方法，其作为药物的用途和含有所述衍生物的药物及其用途公开(公告)号：US08828995B2
公开(公告)日：2014-09-09
申请号：US14003083
申请日：2012-03-07
申请人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
发明人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
IPC分类号： A61K31/51 , C07D291/08 , A61K45/06 , A61K31/542 , A61K31/5415 , C07D515/04
CPC分类号： C07D291/08 , A61K31/5415 , A61K31/542 , A61K45/06 , C07D515/04
摘要： The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上相容的盐。 所述化合物适用于例如治疗高血糖症。
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7.发明授权Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof 有权二取代和三取代的恶噻嗪衍生物，其制备方法，用作药物和含有所述衍生物的药物及其用途公开(公告)号：US08828994B2
公开(公告)日：2014-09-09
申请号：US14002897
申请日：2012-03-07
申请人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
发明人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
IPC分类号： A61K31/51 , C07D291/08 , A61K45/06 , A61K31/54 , C07D291/06 , A61K31/547
CPC分类号： C07D291/08 , A61K31/54 , A61K31/547 , A61K45/06 , C07D291/06
摘要： The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上相容的盐。 所述化合物适用于例如治疗高血糖症。
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8.发明授权Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof 有权被金刚烷和去甲金刚烷取代的苄基 - 恶噻嗪衍生物，含有所述化合物的药物及其用途公开(公告)号：US08809325B2
公开(公告)日：2014-08-19
申请号：US14003498
申请日：2012-03-07
申请人： Thomas Boehme , Kurt Ritter , Christian Engel , Torsten Haack , Stefan Guessregen , Georg Tschank
发明人： Thomas Boehme , Kurt Ritter , Christian Engel , Torsten Haack , Stefan Guessregen , Georg Tschank
IPC分类号： C07D291/06 , A61K31/54
CPC分类号： C07D291/06 , A61K31/54 , C07D291/02
摘要： Disclosed is a benzyl-oxathiazine derivative, as shown in Formula I, the derivative being substituted with adamantane or noradamantane: the variables of which are as described herein; also disclosed is a method of preparation and use of same.
摘要翻译： 公开了如式I所示的苄基 - 恶噻嗪衍生物，衍生物被金刚烷或去金刚烷取代：其变量如本文所述; 还公开了其制备和使用方法。
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9.发明授权Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof 有权四取代的噻嗪衍生物，其制备方法，它们作为含有所述衍生物的药物和药物的用途及其用途公开(公告)号：US08871758B2
公开(公告)日：2014-10-28
申请号：US14003080
申请日：2012-03-07
申请人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
发明人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
IPC分类号： A61K31/51 , A61K45/06 , C07D419/12 , C07D515/20 , A61K31/541 , A61K31/547 , C07D515/10 , C07D291/02 , C07D291/06 , A61K31/54 , C07D291/08
CPC分类号： C07D291/06 , A61K31/54 , A61K31/541 , A61K31/547 , A61K45/06 , C07D291/02 , C07D291/08 , C07D419/12 , C07D515/10 , C07D515/20
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上可接受的盐。 所述化合物是合适的。 用于治疗高血糖症。
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10.发明申请OXATHIAZINE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL OR HETEROMETHYLENE GROUPS, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF 有权用苄基或异二甲苯基取代的氧化氮衍生物，其生产方法，用作含有所述衍生物的药物和药物及其用途公开(公告)号：US20140066437A1
公开(公告)日：2014-03-06
申请号：US14003392
申请日：2012-03-07
申请人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
发明人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
IPC分类号： A61K31/54 , A61K47/06 , C07D419/14 , C07D291/06 , C07D419/10
CPC分类号： A61K31/54 , A61K47/06 , C07D291/06 , C07D419/10 , C07D419/14
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上可接受的盐。 所述化合物是合适的。 用于治疗高血糖症。
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