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1.发明授权Azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments 有权亚烷基取代的芳基噻吩并嘧啶酮，其制备方法及其作为药物的用途公开(公告)号：US08828991B2
公开(公告)日：2014-09-09
申请号：US12191630
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： C07D495/04 , A61K31/519 , C07D403/10 , C07D239/91 , C07D491/04 , A61K31/517 , A61K31/551 , A61P3/10 , A61P3/04 , C12N9/99
CPC分类号： C07D491/04 , C07D239/91 , C07D403/10 , C07D495/04 , C12N9/99
摘要： The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives, of the Formula (I); and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone according to Formula (I) or its derivative, and the use of the azacyclyl-substituted arylthienopyrimidinones according to Formula (I) and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物; 以及它们的生理学耐受的盐和生理功能衍生物及其制备方法，包含至少一种式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮或其衍生物的药物，以及根据式（I）的氮杂环酰基取代的芳基噻吩并嘧啶酮及其衍生物 作为MCH拮抗剂。
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2.发明授权Amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments 有权氨基醇取代的芳基噻吩并嘧啶酮，其制备方法及其用作药物公开(公告)号：US08853208B2
公开(公告)日：2014-10-07
申请号：US12191678
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00 , A61P3/10 , A61P3/04
CPC分类号： C07D495/04 , C07D519/00
摘要： The invention relates to amino alcohol-substituted arylthienopyrimidinones having a formula I and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及具有式I及其衍生物的氨基醇取代的芳基噻吩并嘧啶酮及其生理上耐受的盐和生理功能衍生物，其制备方法，包含本发明的至少一种氨基醇取代的芳基噻吩并嘧啶酮或其衍生物的药物及其用途 的本发明的氨基醇取代的芳基噻吩并嘧啶酮及其衍生物作为MCH拮抗剂。
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3.发明授权公开(公告)号：US08609731B2
公开(公告)日：2013-12-17
申请号：US12705140
申请日：2010-02-12
IPC分类号： A61K31/40 , A61K31/165 , C07C233/04 , C07C233/06
CPC分类号： C07D405/12 , A61K31/397 , A61K31/4025 , A61K31/4525 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D307/12
摘要： The invention relates to substituted tetrahydronaphthalenes and derivatives thereof, and also to the physiologically compatible salts and physiologically functional derivatives thereof, to preparation thereof, to medicaments comprising at least one inventive substituted tetrahydronaphthalene or derivative thereof, and to the use of the inventive substituted tetrahydronaphthalenes and derivatives thereof as medicaments.
摘要翻译： 本发明涉及取代的四氢萘及其衍生物，以及其生理上相容的盐和生理功能衍生物及其制备方法，涉及包含至少一种本发明取代的四氢化萘或其衍生物的药物，以及本发明取代的四氢萘和 其衍生物作为药物。
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4.发明授权Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments 有权偶氮酰基取代的芳基二氢异喹啉酮，其制备方法及其作为药物的用途公开(公告)号：US08822495B2
公开(公告)日：2014-09-02
申请号：US12191662
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4725 , C07D405/14 , C07D401/14 , C07D401/10 , C07D487/04 , C07D487/10 , C07D417/14 , C07D513/04 , C07D413/14 , C07D407/14 , C07D413/04
CPC分类号： A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/10 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氮杂环酰基取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氮杂环酰基取代的芳基二氢异喹啉酮或其衍生物的药物，以及使用偶氮基酰基取代的芳基二氢异喹啉酮 的本发明及其衍生物作为MCH拮抗剂。
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5.发明授权Aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments 有权氨基醇取代的芳基二氢异喹啉酮，其制备方法及其作为药物的用途公开(公告)号：US08501771B2
公开(公告)日：2013-08-06
申请号：US12191697
申请日：2008-08-14
申请人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
发明人： Lothar Schwink , Siegfried Stengelin , Matthias Gossel , Gerhard Hessler , Torsten Haack , Petra Lennig
IPC分类号： A01N43/42 , A61K31/47 , C07D217/22
CPC分类号： C07D471/04 , C07D217/24 , C07D401/12 , C07D451/06 , C07D453/02 , C07D455/06
摘要： The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.
摘要翻译： 本发明涉及氨基醇取代的芳基二氢异喹啉酮及其衍生物及其生理上耐受的盐和生理功能衍生物，其制备方法，包含至少一种本发明的氨基醇取代的芳基二氢异喹啉酮或其衍生物的药物，以及氨基醇取代的芳基二氢异喹啉酮的用途 的本发明及其衍生物作为MCH拮抗剂。
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公开(公告)号：US08357686B2
公开(公告)日：2013-01-22
申请号：US12489653
申请日：2009-06-23
IPC分类号： A61K31/4985 , A61K31/435 , A61K31/46 , A61K31/454 , C07D455/02 , C07D451/02 , C07D403/12 , C07D487/04 , C07D401/14 , C07D405/14 , A61P3/04
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description as well as to pharmaceutical compositions and medical treatments employing these compounds.
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7.发明授权Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament 有权芳基取代的多环胺，其制备方法及其作为药物的用途公开(公告)号：US08586609B2
公开(公告)日：2013-11-19
申请号：US12846075
申请日：2010-07-29
IPC分类号： C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D401/14 , C07D498/10 , C07D417/14 , A61K31/4545 , A61K31/407 , A61K31/454 , A61K31/424 , A61K31/4439 , A61K31/427 , A61P3/06 , A61P3/10
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.
摘要翻译： 本发明涉及式I的芳基取代的多环胺，特别是双环胺，以及其生理上耐受的盐和生理功能衍生物; 在说明书中解释符号和自由基以及含有它们的药物组合物以及使用它们的治疗方法。
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8.发明授权Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament 有权芳基取代的多环胺，其制备方法及其作为药物的用途公开(公告)号：US07569583B2
公开(公告)日：2009-08-04
申请号：US11675646
申请日：2007-02-16
IPC分类号： A61K31/44 , A01N43/90 , C07D455/02
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description as well as to pharmaceutical compositions and medical treatments employing these compounds.
摘要翻译： 本发明涉及式I的芳基取代的多环胺，特别是双环胺，以及其生理上耐受的盐和生理功能衍生物; 在说明书中解释符号和基团以及使用这些化合物的药物组合物和医疗处理。
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公开(公告)号：US08163741B2
公开(公告)日：2012-04-24
申请号：US12489648
申请日：2009-06-23
IPC分类号： A61K31/535 , A61K31/44 , A01N43/42 , A01N43/90
CPC分类号： C07D471/04 , C07D471/08 , C07D487/04
摘要： The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description.
摘要翻译： 本发明涉及式I的芳基取代的多环胺，特别是双环胺，以及其生理上耐受的盐和生理功能衍生物的治疗用途; 在描述中解释符号和基团。
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![Hexahydro-pyrazino[1,2-A]pyrimidine-4,7-dione derivatives substituted with amino acids](/abs-image/US/2011/08/09/US07994168B2/abs.jpg.150x150.jpg)
10.发明授权Hexahydro-pyrazino[1,2-A]pyrimidine-4,7-dione derivatives substituted with amino acids 有权用氨基酸取代的六氢 - 吡嗪并[1,2-A]嘧啶-4,7-二酮衍生物公开(公告)号：US07994168B2
公开(公告)日：2011-08-09
申请号：US11677067
申请日：2007-02-21
申请人： Petra Lennig , Siegfried Stengelin , Thomas Klabunde , Matthias Gossel , Pavel Safar , James Spoonamore , Gregory Merriman , Joseph T Klein , Brian Whiteley , Carolina Lanter , Kenneth Bordeau , Zhaoxia Yang , Martin Smrcina
发明人： Petra Lennig , Siegfried Stengelin , Thomas Klabunde , Matthias Gossel , Pavel Safar , James Spoonamore , Gregory Merriman , Joseph T Klein , Brian Whiteley , Carolina Lanter , Kenneth Bordeau , Zhaoxia Yang , Martin Smrcina
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/04
CPC分类号： C07D487/04
摘要： The invention relates to substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives substituted with amino acids, and to the physiologically tolerated salts thereof, processes for their preparation and their use as medicaments.
摘要翻译： 本发明涉及被氨基酸取代的取代六氢吡嗪并[1,2-a]嘧啶-4,7-二酮衍生物及其生理学上可耐受的盐，其制备方法及其用作药物。
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