公开(公告)号：US06820014B2

公开(公告)日：2004-11-16

申请号：US10323088

申请日：2002-12-18

申请人： Louis Ferrero ,  Marc Pissavini ,  Leonhard Zastrow

发明人： Louis Ferrero ,  Marc Pissavini ,  Leonhard Zastrow

IPC分类号： G01N21/33 ,  G01N21/59

CPC分类号： A61K8/35 ,  A61K8/37 ,  A61Q17/04 ,  G01N21/33 ,  G01N21/59

摘要： The invention relates to a new method for determination of realistic UV protection factors or bread spectrum indices of a sunscreen preparation. Realistic UV protection factors are calculable by determination of the theoretical and the experimental UV absorbances of known UV filters in wavelength steps of about 5 nm in the range of 290-400 nm from a definite basic formulation (emulsion, gel etc.) and on a transparent substrate and introducing of the values in a mathematical model. These factors are in conformity with values measured in vivo. The number of the experiments for developing new formulations are significant reduced because only basic formulation, kind and concentration of the filters have to enter.

摘要翻译： 本发明涉及一种用于确定防晒制剂的真实紫外线防护因子或面包光谱指数的新方法。 通过确定已知紫外线滤光片的理论和实验紫外线吸收度可以通过确定在约5nm的范围内的波长步骤在290-400nm范围内从确定的碱性配方（乳液，凝胶等）和在 透明衬底和数值模型中的值的引入。 这些因素与体内测量的值一致。 开发新制剂的实验数量显着减少，因为只有基本配方，过滤器的种类和浓度必须进入。

公开(公告)号：US20080224059A1

公开(公告)日：2008-09-18

申请号：US11568148

申请日：2005-04-14

申请人： Louis Ferrero ,  Leonhard Zastrow ,  Karin Golz-Berner ,  Norbert Groth ,  Thomas Herrling

发明人： Louis Ferrero ,  Leonhard Zastrow ,  Karin Golz-Berner ,  Norbert Groth ,  Thomas Herrling

IPC分类号： G01J1/42

CPC分类号： G01R33/60

摘要： The invention relates to a method for determining an integral sun protection factor (∫SPF or iSPF) which encompasses both UVA and UVB radiation and can be used for classifying cosmetic and dermatological sunscreens. The method comprises the steps of applying a defined amount of the sunscreen onto a defined area of a skin substrate impregnated with a spin trap, exposing the skin substrate to a defined amount of UVA- and UVB rays by a sun simulator, subjecting the skin substrate exposed to radiation to an electron spin resonance (ESR) measurement, recording the number of free radicals trapped as a real number×1012 free radicals/mg of skin sample, and determining the integral sun protection factor ∫SPF according to the equations (1) and (2) and (8) ∫ S   P   F = E 0 E ( 1 ) log 10  ( E ) = a · log 10  ( X · 1000 ) + b ( 2 ) E = 10 log   10  ( E ) . ( 8 )

公开(公告)号：US5951967A

公开(公告)日：1999-09-14

申请号：US973605

申请日：1998-01-28

申请人： Karin Golz ,  Leonhard Zastrow ,  Klaus Stanzl ,  Jacques Gerbron ,  Louis Ferrero

发明人： Karin Golz ,  Leonhard Zastrow ,  Klaus Stanzl ,  Jacques Gerbron ,  Louis Ferrero

IPC分类号： A61K8/00 ,  A61K8/03 ,  A61K8/25 ,  A61K8/26 ,  A61K8/29 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/41 ,  A61K8/46 ,  A61K8/97 ,  A61K8/98 ,  A61Q17/04 ,  A61K7/42 ,  A61K7/00 ,  A61K7/44

CPC分类号： A61K8/03 ,  A61Q17/04

摘要： A multi-phase sunscreen agent, characterized by at least two phases that are liquid to pasty or gelatinous and separate from each other spontaneously within seconds to less than ten minutes after a brief and gentle mixing process lasting less than one minute without any essential application of force, where at least one phase contains a UV filter.

摘要翻译： PCT No.PCT / DE96 / 01046 Sec。 371日期1998年1月28日 102（e）1998年1月28日PCT PCT 1996年6月7日PCT公布。 公开号WO96 / 41613 日期：1996年12月27日一种多相防晒剂，其特征在于至少两相是液体糊状或凝胶状，并且在持续不到一分钟的短暂且温和的混合过程之后，在数秒至少于十分钟内自发分离 没有任何基本的施加力，其中至少一个相包含UV过滤器。

公开(公告)号：US6106847A

公开(公告)日：2000-08-22

申请号：US924241

申请日：1997-09-05

申请人： Louis Ferrero ,  Karin Golz ,  Leonhard Zastrow ,  Klaus Stanzl

发明人： Louis Ferrero ,  Karin Golz ,  Leonhard Zastrow ,  Klaus Stanzl

IPC分类号： A61K8/06 ,  A61Q17/04 ,  A61K7/48

CPC分类号： A61Q17/04 ,  A61K8/066 ,  Y10S514/937 ,  Y10S514/938

摘要： The invention relates to a stable multiple phase emulsion of the O.sub.1 /W/O.sub.2 type with high proportions of the primary O.sub.1 /W emulsion. The new emulsions have an emulsifier-free primary oil-in-water phase consisting of a viscoplastic aqueous gel containing the finely distributed inner oil droplets together with a gelling agent, wherein the thixotropic primary oil-in-water phase has a yield point in the range from 20 to 100 Pa and a plastic viscosity of 0.01 to 0.1 Pa.multidot.s and contains at least one lipophilic agent in the primary oil; and a secondary oil phase in which the primary oil-in-water phase is present together with a lipophilic emulsifier; and wherein the proportion of the inner oily phase is from 10 to 35 % by weight relative to the total weight of the emulsion. The higher proportions of the inner oily phase render possible higher proportions of organic sun protection agents with simultaneous avoidance of skin irritations.

摘要翻译： 本发明涉及具有高比例的主要O1 / W乳液的O1 / W / O2型稳定的多相乳液。 新的乳液具有不含乳化剂的初级水包油相，其由含有细分散的内部油滴的胶粘剂水凝胶与胶凝剂组成，其中触变性初级水包油相具有屈服点 范围为20〜100Pa，塑性粘度为0.01〜0.1Pax，在原油中含有至少一种亲脂性试剂; 和主要油包水相与亲脂性乳化剂一起存在的次级油相; 并且其中所述内部油相的比例相对于所述乳液的总重量为10至35重量％。 内部油相的比例越高，可以提供更高比例的有机防晒剂，同时避免皮肤刺激。

公开(公告)号：US07567080B2

公开(公告)日：2009-07-28

申请号：US11568148

申请日：2005-04-14

申请人： Louis Ferrero ,  Leonhard Zastrow ,  Karin Golz-Berner ,  Norbert Groth ,  Thomas Herrling

发明人： Louis Ferrero ,  Leonhard Zastrow ,  Karin Golz-Berner ,  Norbert Groth ,  Thomas Herrling

IPC分类号： G01V3/00

CPC分类号： G01R33/60

摘要： The invention relates to a method for determining an integral sun protection factor (∫ SPF or iSPF) which encompasses both UVA and UVB radiation and can be used for classifying cosmetic and dermatological sunscreens. The method comprises the steps of applying a defined amount of the sunscreen onto a defined area of a skin substrate impregnated with a spin trap, exposing the skin substrate to a defined amount of UVA- and UVB rays by a sun simulator, subjecting the skin substrate exposed to radiation to an electron spin resonance (ESR) measurement, recording the number of free radicals trapped as a real number×1012 free radicals/mg of skin sample, and determining the integral sun protection factor ∫ SPF according to the equations (1) and (2) and (8) ∫ S ⁢ ⁢ P ⁢ ⁢ F = E 0 E ( 1 ) log 10 ⁡ ( E ) = a · log 10 ⁡ ( X · 1000 ) + b ( 2 ) E = 10 log ⁢ ⁢ 10 ⁢ ( E ) . ( 8 )

公开(公告)号：US5478561A

公开(公告)日：1995-12-26

申请号：US179545

申请日：1994-01-10

申请人： Louis Ferrero

发明人： Louis Ferrero

IPC分类号： A61K8/30 ,  A61K8/00 ,  A61K8/06 ,  A61K8/31 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/67 ,  A61K8/73 ,  A61K8/86 ,  A61K8/90 ,  A61K8/97 ,  A61K8/98 ,  A61K9/113 ,  A61K31/215 ,  A61K31/355 ,  A61P3/02 ,  A61P17/00 ,  A61Q17/04 ,  A61Q19/00 ,  B01F3/08 ,  B01F17/00 ,  B01F17/42 ,  B01F17/52 ,  A61K7/00

CPC分类号： B01F3/0811 ,  A61K8/066 ,  A61K9/113 ,  A61Q19/00 ,  B01F17/0028 ,  B01F17/0092 ,  B01F2003/083 ,  B01F2003/0838 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/94 ,  Y10S514/941 ,  Y10S514/943

摘要： The invention relates to a novel process for the preparation of stable complex multiple emulsions of the water-oil-water type which are well suited for use in cosmetic preparations. The primary emulsions of the W/O type are prepared in the presence of both a non-ionic polymeric lipophilic emulsifier and a non-ionic polymeric stabiliser each preferably having an HLB value in the range from 6 to 10. In a second process step more water containing a hydrophilic emulsifier having a higher HLB value, preferably in the range from 12 to 25, is added to the primary emulsion until phase inversion occurs. It is important that the procedure in this second process step is not reversed, i.e. that the primary emulsion is not added to the aqueous phase. Further active substances, such as UV filters and vitamins, may be added to the aqueous or oil phase respectively. In a third process step hydrating agents and/or gelling agents may be added, thus increasing the viscosity without impairing the stability of the multiple emulsion.

摘要翻译： 本发明涉及一种制备适用于化妆品制剂的水 - 油 - 水型稳定复合多重乳液的新方法。 W / O型的主要乳液在非离子聚合物亲脂性乳化剂和非离子聚合物稳定剂的存在下制备，各自优选具有在6至10范围内的HLB值。在第二工艺步骤中， 将含有HLB值较高，优选在12至25范围内的亲水乳化剂的水加入到主乳液中，直至发生相转化。 重要的是在该第二工艺步骤中的步骤不被逆转，即初级乳液不加入到水相中。 可以分别向水相或油相中加入其它活性物质，如紫外线过滤剂和维生素。 在第三工艺步骤中，可以加入水合剂和/或胶凝剂，从而增加粘度，而不损害多重乳液的稳定性。