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    PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    8.
    发明申请
    PLATINUM-N-HETEROCYCLIC CARBENE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 有权
    铂 - N-杂环碳源衍生物，其制备方法及其治疗用途

    公开(公告)号：US20110172199A1

    公开(公告)日：2011-07-14

    申请号：US12874815

    申请日：2010-09-02

    申请人： Patrick MAILLIET ,  Angela MARINETTI ,  Myriem SKANDER

    发明人： Patrick MAILLIET ,  Angela MARINETTI ,  Myriem SKANDER

    IPC分类号： A61K31/555 ,  C07F15/00 ,  A61P35/00

    CPC分类号： C07F15/0086 ,  A61K31/555

    摘要： The invention relates to the platinum N-heterocycle derivatives of general formula (I) in which—R1 and/or R2 are, independently of one another, an aryl or aralkyl group, each optionally substituted, a linear or branched C1-C6 alkyl group, a monocyclic C3-C7 cycloalkyl group or a linear or branched C2-C6 alkenyl group, or else R′ is a hydrogen atom and R is a group selected from the following groups: cycloalkyl or heterocycloalkyl, which is monocyclic or bicyclic and has from 3 to 8 carbon atoms, or benzyl, which is optionally substituted, or else R and R′ form, together with NH, a C3-C8 monocyclic or bicyclic heterocycloalkyl, V is a nitrogen atom or a C—R4 radical, R3 and/or R4 are hydrogen or a phenyl group or R3 and R4 may also together form a C3-C6 alkylene radical or a C3-C6 heteroalkylene radical with one or more nitrogenous heteroatoms, it being possible for the carbon atoms of the heteroalkylene radical to be modified in the form of a carbonyl radical, and X is iodine, bromine, chlorine or a nitrato (—ONO2) group.

    摘要翻译： 本发明涉及通式（I）的铂N-杂环衍生物，其中-R 1和/或R 2彼此独立地为任选被取代的直链或支链C 1 -C 6烷基的芳基或芳烷基 ，单环C 3 -C 7环烷基或直链或支链C 2 -C 6烯基，或者R'是氢原子，R是选自以下基团的基团：环烷基或杂环烷基，其是单环或双环的，并且具有 3至8个碳原子，或任选被取代的苄基，或者R和R'与NH一起形成C 3 -C 8单环或双环杂环烷基，V是氮原子或C-R 4基团，R 3和/ 或R 4是氢或苯基，或者R 3和R 4也可以与一个或多个含氮杂原子一起形成C 3 -C 6亚烷基或C 3 -C 6杂亚烷基，杂亚烷基的碳原子可能被修饰 以羰基的形式，X为碘， 溴，氯或硝基（-ONO 2）基团。