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公开(公告)号：US20070203142A1
公开(公告)日：2007-08-30
申请号：US11654375
申请日：2007-01-17
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： A61K31/53 , A61K31/513 , A61K31/506 , C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07767816B2
公开(公告)日：2010-08-03
申请号：US11654375
申请日：2007-01-17
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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![Pyrrolo[2,3-D]pyrimidines as inhibitors of Janus kinases](/abs-image/US/2013/11/12/US08580802B2/abs.jpg.150x150.jpg)
公开(公告)号：US08580802B2
公开(公告)日：2013-11-12
申请号：US11528779
申请日：2006-09-28
申请人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
IPC分类号： C07D487/04 , C07D295/192 , A61K31/519 , A61K31/5377 , A61K31/496 , A61P25/28 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of the following structural formula: which are useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及以下结构式的化合物：其可用作蛋白激酶的抑制剂，特别是JAK家族激酶的抑制剂。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08163917B2
公开(公告)日：2012-04-24
申请号：US12775885
申请日：2010-05-07
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08921376B2
公开(公告)日：2014-12-30
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070207995A1
公开(公告)日：2007-09-06
申请号：US11528779
申请日：2006-09-28
申请人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
发明人： Francesco Salituro , Luc Farmer , Tiansheng Wang , Jian Wang , Randy Bethiel , Marion Wannamaker , Gabriel Martinez-Botella , John Duffy , Alexander Aronov , David Lauffer , Albert Pierce
IPC分类号： A61K31/5377 , A61K31/52 , A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070135466A1
公开(公告)日：2007-06-14
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： A61K31/506 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20100311743A1
公开(公告)日：2010-12-09
申请号：US12775885
申请日：2010-05-07
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： A61K31/517 , C07D471/04 , C07D495/10 , A61K31/506 , A61K31/496 , A61K31/5377 , A61K31/53 , A61P9/00 , A61P25/28 , A61P37/00 , A61P29/00 , A61P11/06 , A61P3/10 , A61P25/16 , A61P25/18 , A61P37/06 , A61P35/02 , A61P35/00 , A61P19/02 , C12N5/00
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090227607A1
公开(公告)日：2009-09-10
申请号：US12245069
申请日：2008-10-03
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04 , C12N9/99
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20090088445A1
公开(公告)日：2009-04-02
申请号：US11732845
申请日：2007-04-05
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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