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公开(公告)号：US20070191369A1
公开(公告)日：2007-08-16
申请号：US11606524
申请日：2006-11-30
Applicant: David Lauffer , Alexander Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
Inventor： David Lauffer , Alexander Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
IPC: A61K31/53 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/4439 , A61K31/433 , C07D498/04
CPC classification number: C07D498/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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![PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JAK2 INHIBITORS](/abs-image/US/2011/05/19/US20110118255A1/abs.jpg.150x150.jpg)
公开(公告)号：US20110118255A1
公开(公告)日：2011-05-19
申请号：US12817785
申请日：2010-06-17
Applicant: Mark LEDEBOER , Valerie MARONE , Michelle STEWART , David MESSERSMITH , John DUFFY , Gabriel MARTINEZ BOTELLA , Jon COME , Huai GAO , Albert PIERCE , Francesco SALITURO
Inventor： Mark LEDEBOER , Valerie MARONE , Michelle STEWART , David MESSERSMITH , John DUFFY , Gabriel MARTINEZ BOTELLA , Jon COME , Huai GAO , Albert PIERCE , Francesco SALITURO
IPC: A61K31/519 , C07D487/04 , A61K31/5377 , A61P35/04 , C12N9/99
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.
Abstract translation: 本发明涉及可用作JAK2激酶选择性抑制剂的式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US20100190774A1
公开(公告)日：2010-07-29
申请号：US12756301
申请日：2010-04-08
Applicant: David J. Lauffer , Alexander Aronov , Pan Li , David D. Deininger , Kira McGinty , Dean Stamos , Jon H. Come , Michelle Stewart
Inventor： David J. Lauffer , Alexander Aronov , Pan Li , David D. Deininger , Kira McGinty , Dean Stamos , Jon H. Come , Michelle Stewart
IPC: A61K31/55 , C07D513/04 , A61K31/433 , A61P35/00 , A61P35/02 , A61K31/4439 , A61K31/5377 , A61K31/454 , C07D487/04 , A61K31/5025 , A61K31/551 , A61K31/549
CPC classification number: C07D498/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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Patent Agency Ranking
![Pyrazolo[1,5-a]pyrimidines useful as JAK2 inhibitors](/abs-image/US/2015/01/20/US08937064B2/abs.jpg.150x150.jpg)
公开(公告)号：US08937064B2
公开(公告)日：2015-01-20
申请号：US12817785
申请日：2010-06-17
Applicant: Mark Ledeboer , Valerie Marone , Michelle Stewart , David Messersmith , John Duffy , Gabriel Martinez Botella , Jon Come , Huai Gao , Albert Pierce , Francesco Salituro
Inventor： Mark Ledeboer , Valerie Marone , Michelle Stewart , David Messersmith , John Duffy , Gabriel Martinez Botella , Jon Come , Huai Gao , Albert Pierce , Francesco Salituro
IPC: A61K31/535 , C07D415/00 , C07D487/00 , A01N43/90 , C07D487/04
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.
Abstract translation: 本发明涉及可用作JAK2激酶选择性抑制剂的式（I）化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号：US08921376B2
公开(公告)日：2014-12-30
申请号：US11438748
申请日：2006-05-22
Applicant: Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
Inventor： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC: C07D471/04 , A61K31/437 , C07D487/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07998987B2
公开(公告)日：2011-08-16
申请号：US12756301
申请日：2010-04-08
Applicant: David Lauffer , Alex Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
Inventor： David Lauffer , Alex Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
IPC: C07D513/04 , A61K31/433
CPC classification number: C07D498/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号：US07728017B2
公开(公告)日：2010-06-01
申请号：US11606524
申请日：2006-11-30
Applicant: David J. Lauffer , Alexander Aronov , Pan Li , David D. Deininger , Kira McGinty , Dean Stamos , Jon H. Come , Michelle Stewart
Inventor： David J. Lauffer , Alexander Aronov , Pan Li , David D. Deininger , Kira McGinty , Dean Stamos , Jon H. Come , Michelle Stewart
IPC: C07D513/04 , A61K31/433
CPC classification number: C07D498/04 , C07D487/04 , C07D513/04
Abstract: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
Abstract translation: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号：US20070135466A1
公开(公告)日：2007-06-14
申请号：US11438748
申请日：2006-05-22
Applicant: Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
Inventor： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC: A61K31/506 , A61K31/4745 , C07D471/02
CPC classification number: C07D471/04 , C07D487/04
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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