公开(公告)号：US09566540B2

公开(公告)日：2017-02-14

申请号：US14003833

申请日：2012-03-28

申请人： Luc Felden ,  Sebastien Jouette

发明人： Luc Felden ,  Sebastien Jouette

IPC分类号： B01D21/26 ,  B01D17/02 ,  B01D17/00 ,  B01D61/18 ,  B01D63/16 ,  B04B5/04 ,  B01D71/34

CPC分类号： B01D21/262 ,  B01D17/0217 ,  B01D17/085 ,  B01D61/18 ,  B01D63/16 ,  B01D71/34 ,  B01D2315/02 ,  B04B5/04 ,  B04B5/0407 ,  B04B2005/0435 ,  B04B2005/0478 ,  B04B2005/0485

摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.

摘要翻译： 本发明提供了一种过滤和离心装置，其包括筒体，桶中用于容纳要处理的流体样品的容积，过滤介质，至少一个可在筒体中移动的活塞，以迫使体积中的流体通过过滤介质至 产生滤液和颗粒物质造粒的空间。 该装置是可离心的，并且所述空间位于该容积中或与该体积连通，并且优选远离过滤介质，使得该颗粒材料在该装置的离心过程中不会或至少不完全堵塞过滤介质。 本发明还提供了一种用于样品的无菌过滤的方法，包括以下步骤：将样品引入这种装置的体积中，使装置进行离心以将包含在样品中的颗粒材料在远离过滤介质的空间 并且向活塞施加力以迫使体积中的样品的流体通过过滤介质以产生滤液。 通过在离心力的影响下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。 此外，整个过程可以在相同的装置中进行，而不必去除样品用于任何中间澄清步骤。

公开(公告)号：US20140051564A1

公开(公告)日：2014-02-20

申请号：US14003833

申请日：2012-03-28

申请人： Luc Felden ,  Sebastien Jouette

发明人： Luc Felden ,  Sebastien Jouette

IPC分类号： B01D21/26

CPC分类号： B01D21/262 ,  B01D17/0217 ,  B01D17/085 ,  B01D61/18 ,  B01D63/16 ,  B01D71/34 ,  B01D2315/02 ,  B04B5/04 ,  B04B5/0407 ,  B04B2005/0435 ,  B04B2005/0478 ,  B04B2005/0485

摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.

摘要翻译： 本发明提供了一种过滤和离心装置，其包括筒体，桶中用于容纳要处理的流体样品的容积，过滤介质，至少一个可在筒体中移动的活塞，以迫使体积中的流体通过过滤介质至 产生滤液和颗粒物质造粒的空间。 该装置是可离心的，并且所述空间位于该容积中或与该体积连通，并且优选远离过滤介质，使得该颗粒材料在该装置的离心过程中不会或至少不完全堵塞过滤介质。 本发明还提供了一种用于样品的无菌过滤的方法，包括以下步骤：将样品引入这种装置的体积中，使装置进行离心以将包含在样品中的颗粒材料在远离过滤介质的空间 并且向活塞施加力以迫使体积中的样品的流体通过过滤介质以产生滤液。 通过在离心力的影响下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。 此外，整个过程可以在相同的装置中进行，而不必去除样品用于任何中间澄清步骤。